Combes, Valery - University of Technology Sydney

个人简介

Dr Valery Combes obtained her PhD in 2001 from the Universite de la Mediterranee (Marseille France) on the role of endothelial microparticles in the pathogenesis of thrombotic diseases. She then moved to the field of cereral malaria where she studied the vascular damage occuring in this disease. In 2006 she moved to the University of Sydney as a Research fellow and then Senior Research Associate. In 2015, she took a postion of Senior Lecturer at the University of Technology in the Faculty of Science/School of Life Sciences. She is the Leader of the Parasites, Microbes and Host Immunity Team.

研究领域

n the last 5 years, her work has focused on: 1. Defining the role of MP in the pathogenesis of infectious diseases by (i) characterising the role of MP in several in vitro models; (ii) analysing the role of MP as potential immunomodulators, (iii) characterising the cellular origins of MP in human CM, (iv) studying the role of macrophage MP during tuberculosis infection. 2. Increasing the knowledge on the pathogenesis of CM by (i) analysing the molecular interactions between infected erythrocytes and endothelial cells, (ii) deciphering new mechanisms in the pathogenesis of CM. 3. Understanding the molecular mechanisms of MP production and their inhibition by evaluating new inhibitors with potential clinical applications.

近期论文

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Danastas, K, Whittington, CM, Dowland, SN, Combes, V, Murphy, CR & Lindsay, LA 2019, 'Ovarian Hyperstimulation Reduces Vascular Endothelial Growth Factor-A During Uterine Receptivity.', Reproductive sciences (Thousand Oaks, Calif.), pp. 1933719118768703-1933719118768703.View/Download from: UTS OPUS or Publisher's site Gramagliaid, I, Velez, J, Chang, YS, Caparros-Wanderley, W, Combes, V, Grau, G, Stins, MF & Van Der Heyde, HC 2019, 'Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak', PLoS ONE, vol. 14, no. 3.View/Download from: Publisher's site Cohen, A, Zinger, A, Tiberti, N, Grau, GER & Combes, V 2018, 'Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria.', Malaria journal, vol. 17, no. 1, pp. 192-192.View/Download from: UTS OPUS or Publisher's site Subramanian, S, Ugoya, SO, Zhao, Z, McRobb, LS, Grau, GE, Combes, V, Inglis, DW, Gauden, AJ, Lee, VS, Moutrie, V, Santos, ED & Stoodley, MA 2018, 'Stable thrombus formation on irradiated microvascular endothelial cells under pulsatile flow: Pre-testing annexin V-thrombin conjugate for treatment of brain arteriovenous malformations.', Thrombosis research, vol. 167, pp. 104-112.View/Download from: UTS OPUS or Publisher's site Tanaka, A, Allam, VSRR, Simpson, J, Tiberti, N, Shiels, J, To, J, Lund, M, Combes, V, Weldon, S, Taggart, C, Dalton, JP, Phipps, S, Sukkar, MB & Donnelly, S 2018, 'The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 141, no. 6, pp. 2316-2319.View/Download from: UTS OPUS or Publisher's site Gramaglia, I, Velez, J, Combes, V, Grau, GER, Wree, M & van der Heyde, HC 2017, 'Platelets activate a pathogenic response to blood-stage Plasmodium infection but not a protective immune response.', Blood, vol. 129, no. 12, pp. 1669-1679.View/Download from: UTS OPUS or Publisher's site Lee, J, Wen, B, Carter, EA, Combes, V, Grau, GER & Lay, PA 2017, 'Infrared spectroscopic characterization of monocytic microvesicles (microparticles) released upon lipopolysaccharide stimulation.', FASEB Journal, vol. 31, no. 7, pp. 2817-2827.View/Download from: UTS OPUS or Publisher's site Donnelly, S, Huston, WM, Johnson, M, Tiberti, N, Saunders, B, O'Brien, B, Burke, C, Labbate, M & Combes, V 2017, 'Targeting the master regulator mTOR: a new approach to prevent the neurological of consequences of parasitic infections?', Parasites & Vectors, vol. 10, no. 1, pp. 1-6.View/Download from: UTS OPUS or Publisher's site Palasuwan, A, Palasuwan, D, Mahittikorn, A, Chiabchalard, R, Combes, V & Popruk, S 2016, 'Subtype Distribution of Blastocystis in Communities along the Chao Phraya River, Thailand.', The Korean journal of parasitology, vol. 54, no. 4, pp. 455-460.View/Download from: UTS OPUS or Publisher's site Tiberti, N, Latham, SL, Bush, S, Cohen, A, Opoka, RO, John, CC, Juillard, A, Grau, GE & Combes, V 2016, 'Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content', SCIENTIFIC REPORTS, vol. 6.View/Download from: UTS OPUS or Publisher's site Combes, V, Latham, SL, Wen, B, Allison, AC & Grau, GER 2016, 'Diannexin down-modulates tnf-induced endothelial microparticle release by blocking membrane budding process', International Journal of Innovative Medicine and Health Science, vol. 7, pp. 1-11.View/Download from: UTS OPUS Sorrell, TC, Juillard, P-G, Djordjevic, JT, Kaufman-Francis, K, Dietmann, A, Milonig, A, Combes, V & Grau, GER 2016, 'Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans var. grubii strain H99 and Cryptococcus gattii strain R265', MICROBES AND INFECTION, vol. 18, no. 1, pp. 57-67.View/Download from: UTS OPUS or Publisher's site Zinger, A, Latham, SL, Combes, V, Byrne, S, Barnett, MH, Hawke, S & Grau, GE 2016, 'Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients.', Multiple sclerosis (Houndmills, Basingstoke, England), vol. 22, no. 14, pp. 1883-1887.View/Download from: UTS OPUS or Publisher's site Danastas, K, Combes, V, Lindsay, LA, Grau, GER, Thompson, MB & Murphy, CR 2015, 'VEGF(111): new insights in tissue invasion', FRONTIERS IN PHYSIOLOGY, vol. 6.View/Download from: UTS OPUS or Publisher's site Cohen, A, Combes, V & Grau, GE 2015, 'MicroRNAs and Malaria - A Dynamic Interaction Still Incompletely Understood.', Journal of neuroinfectious diseases, vol. 6, no. 1, pp. 165-176.View/Download from: UTS OPUS or Publisher's site Latham, SL, Tiberti, N, Gokoolparsadh, N, Holdaway, K, Couraud, PO, Grau, GER & Combes, V 2015, 'Immuno-analysis of microparticles: probing at the limits of detection', SCIENTIFIC REPORTS, vol. 5.View/Download from: UTS OPUS or Publisher's site Hunt, NH, Ball, HJ, Hansen, AM, Khaw, LT, Guo, J, Bakmiwewa, S, Mitchell, AJ, Combes, V & Grau, GE 2014, 'Cerebral malaria: gamma-interferon redux.', Frontiers in Cellular and Infection Microbiology, vol. 4, pp. 1-12.View/Download from: UTS OPUS or Publisher's site El-Assaad, F, Combes, V, Grau, GE & Jambou, R 2014, 'Potential efficacy of citicoline as adjunct therapy in treatment of cerebral malaria.', Antimicrobial Agents and Chemotherapy, vol. 58, no. 1, pp. 602-605.View/Download from: UTS OPUS or Publisher's site Wheway, J, Latham, SL, Combes, V & Grau, GE 2014, 'Endothelial microparticles interact with and support the proliferation of T cells.', Journal of Immunology, vol. 193, no. 7, pp. 3378-3387.View/Download from: UTS OPUS or Publisher's site Pai, S, Qin, J, Cavanagh, L, Mitchell, A, El-Assaad, F, Jain, R, Combes, V, Hunt, NH, Grau, GE & Weninger, W 2014, 'Real-time imaging reveals the dynamics of leukocyte behaviour during experimental cerebral malaria pathogenesis.', PLoS Pathogens, vol. 10, no. 7, pp. 1-17.View/Download from: UTS OPUS or Publisher's site Wen, B, Combes, V, Bonhoure, A, Weksler, BB, Couraud, PO & Grau, GE 2014, 'Endotoxin-induced monocytic microparticles have contrasting effects on endothelial inflammatory responses.', PLoS ONE, vol. 9, no. 3, pp. 1-11.View/Download from: UTS OPUS or Publisher's site El-Assaad, F, Wheway, J, Hunt, NH, Grau, GE & Combes, V 2014, 'Production, fate and pathogenicity of plasma microparticles in murine cerebral malaria.', PLoS Pathogens, vol. 10, no. 3, pp. 1-14.View/Download from: UTS OPUS or Publisher's site El-Assaad, F, Combes, V & Grau, GE 2014, 'Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria.', Journal of neuroinfectious diseases, vol. 5, no. 1, pp. 1-11.View/Download from: UTS OPUS or Publisher's site