Chen, Hui - University of Technology Sydney

个人简介

Dr Hui Chen is an associate professor in the School of Life Sciences. She is the Director of Advanced Science Program (Pharmaceutical Sciences) and Director of China Programs, Faculty of Science. She holds an International Young Scientist Fellowship awarded by the National Natural Science Foundation of China. Hui finished her PhD degree at The University of Melbourne (Apr 2003 - Apr 2006), where she studied brain appetite and energy metabolism regulation in two mouse models of dietary obesity and cigarette smoking. Then she took up a postdoctoral position at the University of New South Wales (Apr 2006 - Aug 2008), where she moved into a new area of research, dealing with fetal programming of early onset obesity and metabolic disorders. Hui's studies focus on the impact of maternal obesity and cigarette smoking on the neural regulation of appetite and brain glucose metabolism. Hui continued the same research area after she joined UTS in 2008, where her research has been extended to study maternal programming of brain injury, cognitive change, type 2 diabetes, chronic kidney disease, asthma, oxidative stress, mitochondrial integrity, as well as new drug development for weight loss and treating type 2 diabetes. Hui's work during the past 10 years has resulted in several publications in high impact journals, including Diabetologia, Journal of Neural Chemsity, FASEB J, American Journal of Respiratory and Critical Care Medicine, Endocrinology, American Journal of Physiology, and Neuropsychopharmacology. Hui was awarded NHMRC Peter Doherty Fellowship in 2009, although this was not accepted, as it was not compatible with the UTS position.

研究领域

Dr Chen is an expert in animal modeling of human diseases, especially for pre-clinical trials, such as obesity, type 2 diabetes, cognitive change, neuroinjury, asthma, and chronic kidney diseases. Collaborations for pre-clinical trials are welcome. Another major area of Dr Chen's research is dealing with fetal programming of early onset obesity and metabolic disorders using intrauterine and early postnatal intervention in mice. Both genetic and environmental factors can contribute to obesity and gene-diet interactions are also important. Increasing evidence suggests that both maternal phenotype and nutritional state in the early postnatal phase are important in promoting brain, lung and kidney disorders, as well as type 2 diabetes in offspring. Studies carried by Dr Chen focus on the mechanism underlying the detrimental impact of long-term maternal conditions, including obesity, smoking, and e-cigarette smoking. Interventions, such as essential amino acid supplementation and newly invented compounds are being tested to ameliorate or reverse maternal impact. Major techniques used for this work include testing hormone and lipid levels in the blood by biosassays, real-time PCR, western blotting, immunohistochemistry, lipidomics.

近期论文

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Hamedi-Shahraki, S, Eshraghian, M-R, Yekaninejad, M-S, Nikoobakht, M, Rasekhi, A, Chen, H & Pakpour, A 2019, 'Health-related quality of life and medication adherence in elderly patients with epilepsy', NEUROLOGIA I NEUROCHIRURGIA POLSKA, vol. 53, no. 2, pp. 123-130.View/Download from: UTS OPUS or Publisher's site Saffari, M, Lin, CY, Chen, H & Pakpour, AH 2019, 'The role of religious coping and social support on medication adherence and quality of life among the elderly with type 2 diabetes', Quality of Life Research.View/Download from: UTS OPUS or Publisher's site Machaalani, R, Thawley, M, Huang, J & Chen, H 2019, 'Effects of prenatal cigarette smoke exposure on BDNF, PACAP, microglia and gliosis expression in the young male mouse brainstem', NeuroToxicology, vol. 74, pp. 40-46.View/Download from: UTS OPUS or Publisher's site Nguyen, LT, Chen, H, Zaky, A, Pollock, C & Saad, S 2019, 'SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.', The Journal of physiology, vol. 597, no. 2, pp. 467-480.View/Download from: UTS OPUS or Publisher's site Nguyen, LT, Mak, CH, Chen, H, Zaky, AA, Wong, MG, Pollock, CA & Saad, S 2019, 'SIRT1 Attenuates Kidney Disorders in Male Offspring Due to Maternal High-Fat Diet', NUTRIENTS, vol. 11, no. 1.View/Download from: UTS OPUS or Publisher's site Stangenberg, S, Nguyen, LT, Chan, YL, Zaky, A, Pollock, CA, Chen, H & Saad, S 2019, 'Maternal L-carnitine supplementation ameliorates renal underdevelopment and epigenetic changes in male mice offspring due to maternal smoking.', Clinical and experimental pharmacology & physiology, vol. 46, no. 2, pp. 183-193.View/Download from: UTS OPUS or Publisher's site Chen, H, Li, G, Chan, YL, Chapman, DG, Sukjamnong, S, Nguyen, T, Annissa, T, McGrath, KC, Sharma, P & Oliver, BG 2018, 'Maternal E-Cigarette Exposure in Mice Alters DNA Methylation and Lung Cytokine Expression in Offspring.', American Journal of Respiratory Cell and Molecular Biology, vol. 58, no. 3, pp. 366-377.View/Download from: UTS OPUS or Publisher's site Chen, H 2018, 'Gold nanoparticles improve metabolic profile of mice fed a high-fat diet', J Nanobiotechnology, vol. 16.View/Download from: UTS OPUS or Publisher's site Machaalani, R & Chen, H 2018, 'Brain derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB) and nicotine.', Neurotoxicology, vol. 65, pp. 186-195.View/Download from: UTS OPUS or Publisher's site Nguyen, T, Li, GE, Chen, H, Cranfield, CG, McGrath, KC & Gorrie, CA 2018, 'Maternal E-Cigarette Exposure Results in Cognitive and Epigenetic Alterations in Offspring in a Mouse Model.', Chemical research in toxicology, vol. 31, no. 7, pp. 601-611.View/Download from: UTS OPUS or Publisher's site Chen, H, Ng, JPM, Bishop, DP, Milthorpe, BK & Valenzuela, SM 2018, 'Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity', JOURNAL OF NANOBIOTECHNOLOGY, vol. 16.View/Download from: UTS OPUS or Publisher's site Chen, H, Chan, YL, Linnane, C, Mao, Y, Anwer, AG, Sapkota, A, Annissa, TF, Herok, G, Vissel, B, Oliver, BG, Saad, S & Gorrie, CA 2018, 'L-Carnitine and extendin-4 improve outcomes following moderate brain contusion injury.', Scientific reports, vol. 8, no. 1.View/Download from: UTS OPUS or Publisher's site Chen, H, Li, G, Chan, YL, Nguyen, T, van Reyk, D, Saad, S & Oliver, BG 2018, 'Modulation of neural regulators of energy homeostasis, and of inflammation, in the pups of mice exposed to e-cigarettes.', Neuroscience letters, vol. 684, pp. 61-66.View/Download from: UTS OPUS or Publisher's site Glastras, SJ, Chen, H, Pollock, CA & Saad, S 2018, 'Maternal obesity increases the risk of metabolic disease and impacts renal health in offspring.', Bioscience reports, vol. 38, no. 2.View/Download from: UTS OPUS or Publisher's site Larkin, BP, Glastras, SJ, Chen, H, Pollock, CA & Saad, S 2018, 'DNA methylation and the potential role of demethylating agents in prevention of progressive chronic kidney disease.', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 32, no. 10, pp. 5215-5226.View/Download from: UTS OPUS or Publisher's site Li, G, Saad, S, Oliver, BG & Chen, H 2018, 'Heat or Burn? Impacts of Intrauterine Tobacco Smoke and E-Cigarette Vapor Exposure on the Offspring's Health Outcome.', Toxics, vol. 6, no. 3.View/Download from: UTS OPUS or Publisher's site Nguyen, LT, Chen, H, Mak, C, Zaky, A, Pollock, C & Saad, S 2018, 'SRT1720 attenuates obesity and insulin resistance but not liver damage in the offspring due to maternal and postnatal high-fat diet consumption.', American journal of physiology. Endocrinology and metabolism, vol. 315, no. 2, pp. E196-E203.View/Download from: UTS OPUS or Publisher's site Saad, S, Al-Odat, I, Chan, YL, McGrath, KC, Pollock, CA, Oliver, BG & Chen, H 2018, 'Maternal L-carnitine supplementation improves glucose and lipid profiles in female offspring of dams exposed to cigarette smoke.', Clinical and experimental pharmacology & physiology, vol. 45, no. 7, pp. 694-703.View/Download from: UTS OPUS or Publisher's site Sukjamnong, S, Chan, YL, Zakarya, R, Nguyen, LT, Anwer, AG, Zaky, AA, Santiyanont, R, Oliver, BG, Goldys, E, Pollock, CA, Chen, H & Saad, S 2018, 'MitoQ supplementation prevent long-term impact of maternal smoking on renal development, oxidative stress and mitochondrial density in male mice offspring.', Scientific reports, vol. 8, no. 1.View/Download from: UTS OPUS or Publisher's site Saffari, M, Pakpour, AH & Chen, H 2017, 'Factors influencing exclusive breastfeeding among Iranian mothers: A longitudinal population-based study.', Health Promotion Perspectives, vol. 7, no. 1, pp. 34-41.View/Download from: UTS OPUS or Publisher's site Rahmati-Najarkolaci, F, Pakpour, AH, Saffari, M, Hosseini, MS, Hajizadeh, F, Chen, H & Yekaninejad, MS 2017, 'Determinants of Lifestyle Behavior in Iranian Adults with Prediabetes: Applying the Theory of Planned Behavior', ARCHIVES OF IRANIAN MEDICINE, vol. 20, no. 4, pp. 198-204.View/Download from: UTS OPUS Capistrano, SJ, van Reyk, D, Chen, H & Oliver, BG 2017, 'Evidence of Biomass Smoke Exposure as a Causative Factor for the Development of COPD.', Toxics, vol. 5, no. 4, pp. 1-16.View/Download from: UTS OPUS or Publisher's site Chan, YL, Saad, S, Al-Odat, I, Oliver, BG, Pollock, C, Jones, NM & Chen, H 2017, 'Maternal L-Carnitine Supplementation Improves Brain Health in Offspring from Cigarette Smoke Exposed Mothers.', Frontiers in Molecular Neuroscience, vol. 10, pp. 1-15.View/Download from: UTS OPUS or Publisher's site Chan, YL, Saad, S, Machaalani, R, Oliver, BG, Vissel, B, Pollock, C, Jones, NM & Chen, H 2017, 'Maternal Cigarette Smoke Exposure Worsens Neurological Outcomes in Adolescent Offspring with Hypoxic-Ischemic Injury.', Frontiers in Molecular Neuroscience, vol. 10, pp. 1-17.View/Download from: UTS OPUS or Publisher's site Glastras, SJ, Chen, H, Tsang, M, Teh, R, McGrath, RT, Zaky, A, Chen, J, Wong, MG, Pollock, CA & Saad, S 2017, 'The renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet.', PLoS ONE, vol. 12, no. 2, pp. 1-17.View/Download from: UTS OPUS or Publisher's site Nguyen, LT, Chen, H, Pollock, C & Saad, S 2017, 'SIRT1 reduction is associated with sex-specific dysregulation of renal lipid metabolism and stress responses in offspring by maternal high-fat diet.', Scientific Reports, vol. 7, no. 1, pp. 1-13.View/Download from: UTS OPUS or Publisher's site Nguyen, LT, Saad, S, Tan, Y, Pollock, C & Chen, H 2017, 'Maternal high-fat diet induces metabolic stress response disorders in offspring hypothalamus.', Journal of Molecular Endocrinology, vol. 59, no. 1, pp. 81-92.View/Download from: UTS OPUS or Publisher's site