Chapman, David - University of Technology Sydney

个人简介

Dr David Chapman is a translational physiologist with extensive expertise in airways diseases such as chronic obstructive pulmonary disease (COPD) and asthma. Dr Chapman completed his PhD in Medicine at the Woolcock Institute of Medical Research in 2011. David was awarded an NHMRC Early Career Fellowship for 2013 to expand his research at the University of Vermont, USA. He continued at the University of Vermont for a subsequent two years in which he integrated new lung function tests into the Centre’s animal models of respiratory disease and helped initiate an ongoing research program understanding the effect of obesity for patients with asthma. Dr Chapman returned to Australia in December 2016 to lead the Translational Airways Group at the University of Technology Sydney with a joint position in the Airway Physiology Group at the Woolcock Institute of Medical Research. He has an international reputation in lung function measurement, particularly in relation to small airway dysfunction, airway hyperresponsiveness and obesity. His main research interests lie in understanding the way in which interventions such as obesity and tobacco use alter lung function and contribute to respiratory disease. David’s work has been recognised by multiple awards including the 2018 Ann Woolcock Award from the American Thoracic Society for “outstanding contributions and future promise in asthma research”.

研究领域

The link between lung function and co-morbidities in Chronic Obstructive Lung Disease In COPD, the destruction of lung tissue leads to gas trapping and hyperinflation, a condition in which patients breathe at abnormally high lung volumes. Hyperinflation is central to the reduced quality of life in patients with COPD, being correlated with increased symptoms, reduced exercise capacity, reduced cardiac function and worse sleep quality. We are currently investigating novel interventions to reduce hyperinflation in patients with COPD in order to improve exercise capacity, cardiac function and sleep quality. The effect of Obesity on Respiratory Disease Obesity is an important co-morbidity in patients with asthma and Chronic Obstructive Pulmonary Disease (COPD). Obesity is associated with increased respiratory symptoms, a reduced response to therapy and increased frequency of exacerbations. Although the mechanisms are not well understood, it is well know that obesity alters lung function in healthy people and that lung function in patients with respiratory disease is a net result of the effects of obesity and the effects of lung disease. We are currently trying to understand the complex relationship between obesity, respiratory disease and lung function in order to understand the contribution of obesity to the clinical management of obese patients with respiratory disease. The effect of novel nicotine delivery systems on lung development and respiratory disease Tobacco smoking is a major contributor to a multitude of diseases, including contributions to the development and severity of respiratory disease. Despite ample access to Nicotine Replacement Therapy and other smoking cessation tools, many smokers are not successful with long-term quit attempts. Therefore, several new nicotine delivery systems have been introduced in an attempt to reduce the harm due to tobacco smoking, including electronic cigarettes, heat-not-burn tobacco products and low nicotine cigarettes. However, it is unknown whether these are actually safer than tobacco cigarettes and if they are, to what extent. We are currently determining the potential for novel nicotine delivery systems to contribute to respiratory disease using mouse models of in utero exposure and mouse models of allergic airways disease.

近期论文

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Tonga, KO, Berend, N, Thamrin, C, Farah, CS, Jetmalani, K, Chapman, DG & King, GG 2019, 'Lung elastic recoil and ventilation heterogeneity of diffusion-dependent airways in older people with asthma and fixed airflow obstruction.', The European respiratory journal.View/Download from: Publisher's site Peters, U, Subramanian, M, Chapman, DG, Kaminsky, DA, Irvin, CG, Wise, RA, Skloot, GS, Bates, JHT & Dixon, AE 2019, 'BMI but not central obesity predisposes to airway closure during bronchoconstriction', Respirology, vol. 24, no. 6, pp. 543-550.View/Download from: Publisher's site Chamberlain, N, Korwin-Mihavics, BR, Nakada, EM, Bruno, SR, Heppner, DE, Chapman, DG, Hoffman, SM, van der Vliet, A, Suratt, BT, Dienz, O, Alcorn, JF & Anathy, V 2019, 'Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics', Redox Biology, vol. 22.View/Download from: Publisher's site Milne, S, Jetmalani, K, Chapman, DG, Duncan, JM, Farah, CS, Thamrin, C & King, GG 2019, 'Respiratory system reactance reflects communicating lung volume in chronic obstructive pulmonary disease.', Journal of applied physiology (Bethesda, Md. : 1985), vol. 126, no. 5, pp. 1223-1231.View/Download from: Publisher's site Kaminsky, DA, Chapman, DG, Holbrook, JT, Henderson, RJ, Sugar, EA, Mastronarde, J, Teague, WG, Busk, M, Sumino, K, Dixon, AE, Wise, RA & Irvin, CG 2019, 'Older age and obesity are associated with increased airway closure in response to methacholine in patients with asthma', Respirology.View/Download from: Publisher's site King, GG, Farrow, CE & Chapman, DG 2019, 'Dismantling the pathophysiology of asthma using imaging', European respiratory review : an official journal of the European Respiratory Society, vol. 28, no. 152.View/Download from: Publisher's site Nakada, EM, Bhakta, NR, Korwin-Mihavics, BR, Kumar, A, Chamberlain, N, Bruno, SR, Chapman, DG, Hoffman, SM, Daphtary, N, Aliyeva, M, Irvin, CG, Dixon, AE, Woodruff, PG, Amin, S, Poynter, ME, Desai, DH & Anathy, V 2019, 'Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers.', JCI insight, vol. 4, no. 9.View/Download from: Publisher's site Chen, H, Li, G, Chan, YL, Chapman, DG, Sukjamnong, S, Nguyen, T, Annissa, T, McGrath, KC, Sharma, P & Oliver, BG 2018, 'Maternal E-Cigarette Exposure in Mice Alters DNA Methylation and Lung Cytokine Expression in Offspring.', American Journal of Respiratory Cell and Molecular Biology, vol. 58, no. 3, pp. 366-377.View/Download from: UTS OPUS or Publisher's site Jetmalani, K, Thamrin, C, Farah, CS, Bertolin, A, Chapman, DG, Berend, N, Salome, CM & King, GG 2018, 'Peripheral airway dysfunction and relationship with symptoms in smokers with preserved spirometry.', Respirology, vol. 23, no. 5, pp. 512-518.View/Download from: UTS OPUS or Publisher's site Qian, X, Aboushousha, R, van de Wetering, C, Chia, SB, Amiel, E, Schneider, RW, van der Velden, JLJ, Lahue, KG, Hoagland, DA, Casey, DT, Daphtary, N, Ather, JL, Randall, MJ, Aliyeva, M, Black, KE, Chapman, DG, Lundblad, LKA, McMillan, DH, Dixon, AE, Anathy, V, Irvin, CG, Poynter, ME, Wouters, EFM, Vacek, PM, Henket, M, Schleich, F, Louis, R, van der Vliet, A & Janssen-Heininger, YMW 2018, 'IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease.', Journal of Allergy and Clinical Immunology, vol. 142, no. 2.View/Download from: UTS OPUS or Publisher's site Chapman, DG & King, GG 2018, 'Potential clinical utility for the multiple breath nitrogen washout', RESPIROLOGY, vol. 23, no. 8, pp. 729-730.View/Download from: Publisher's site Anathy, V, Lahue, KG, Chapman, DG, Chia, SB, Casey, DT, Aboushousha, R, van der Velden, JLJ, Elko, E, Hoffman, SM, McMillan, DH, Jones, JT, Nolin, JD, Abdalla, S, Schneider, R, Seward, DJ, Roberson, EC, Liptak, MD, Cousins, ME, Butnor, KJ, Taatjes, DJ, Budd, RC, Irvin, CG, Ho, Y-S, Hakem, R, Brown, KK, Matsui, R, Bachschmid, MM, Gomez, JL, Kaminski, N, van der Vliet, A & Janssen-Heininger, YMW 2018, 'Reducing protein oxidation reverses lung fibrosis.', Nature medicine, vol. 24, no. 8, pp. 1128-1135.View/Download from: UTS OPUS or Publisher's site Tonga, KO, King, GG, Farah, CS, Thamrin, C, Tang, FS, Santos, J, Sharma, P, Chapman, DG & Oliver, BG 2018, 'Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma.', Respiratory research, vol. 19, no. 1, pp. 176-176.View/Download from: UTS OPUS or Publisher's site Gazzola, M, Lortie, K, Henry, C, Mailhot-Larouche, S, Chapman, DG, Couture, C, Seow, CY, Paré, PD, King, GG, Boulet, L-P & Bossé, Y 2017, 'Airway smooth muscle tone increases airway responsiveness in healthy young adults.', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 312, no. 3, pp. L348-L357.View/Download from: UTS OPUS or Publisher's site Chapman, DG, Mougey, EB, Van der Velden, JL, Lahue, KG, Aliyeva, M, Daphtary, N, George, KL, Hoffman, SM, Schneider, RW, Tracy, RP, Worthen, GS, Poynter, ME, Peters, SP, Lima, JJ, Janssen-Heininger, YMW & Irvin, CG 2017, 'The Duffy antigen receptor for chemokines regulates asthma pathophysiology.', Clinical and Experimental Allergy, vol. 47, no. 9, pp. 1214-1222.View/Download from: UTS OPUS or Publisher's site Jetmalani, K, Chapman, DG, Thamrin, C, Farah, CS, Berend, N, Salome, CM & King, GG 2016, 'Bronchodilator responsiveness of peripheral airways in smokers with normal spirometry', RESPIROLOGY, vol. 21, no. 7, pp. 1270-1276.View/Download from: Publisher's site Siddesha, JM, Nakada, EM, Mihavics, BR, Hoffman, SM, Rattu, GK, Chamberlain, N, Cahoon, JM, Lahue, KG, Daphtary, N, Aliyeva, M, Chapman, DG, Desai, DH, Poynter, ME & Anathy, V 2016, 'Effect of a chemical chaperone, tauroursodeoxycholic acid, on HDM-induced allergic airway disease', AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 310, no. 11, pp. L1243-L1259.View/Download from: Publisher's site Hoffman, SM, Chapman, DG, Lahue, KG, Cahoon, JM, Rattu, GK, Daphtary, N, Aliyeva, M, Fortner, KA, Erzurum, SC, Comhair, SAA, Woodruff, PG, Bhakta, N, Dixon, AE, Irvin, CG, Janssen-Heininger, YMW, Poynter, ME & Anathy, V 2016, 'Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 137, no. 3, pp. 822-+.View/Download from: Publisher's site Hoffman, SM, Qian, X, Nolin, JD, Chapman, DG, Chia, SB, Lahue, KG, Schneider, R, Ather, JL, Randall, MJ, McMillan, DH, Jones, JT, Taatjes, DJ, Aliyeva, M, Daphtary, N, Abdalla, S, Lundblad, LKA, Ho, Y-S, Anathy, V, Irvin, CG, Wouters, EFM, Reynaert, NL, Dixon, AE, van der Vliet, A, Poynter, ME & Janssen-Heininger, YMW 2016, 'Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice.', American journal of respiratory cell and molecular biology, vol. 55, no. 3, pp. 377-386.View/Download from: Publisher's site Hoffman, SM, Nolin, JD, Jones, JT, Lahue, KG, Chapman, DG, Aliyeva, M, Daphtary, N, Lundblad, LKA, Abdalla, S, Ather, JL, Ho, Y-S, Irvin, CG, Anathy, V, Wouters, EFM, Poynter, ME & Janssen-Heininger, YMW 2016, 'Ablation of the Thiol Transferase Glutaredoxin-1 Augments Protein S-Glutathionylation and Modulates Type 2 Inflammatory Responses and IL-17 in a House Dust Mite Model of Allergic Airway Disease in Mice.', Annals of the American Thoracic Society, vol. 13 Suppl 1, p. S97.View/Download from: Publisher's site van der Velden, JLJ, Ye, Y, Nolin, JD, Hoffman, SM, Chapman, DG, Lahue, KG, Abdalla, S, Chen, P, Liu, Y, Bennett, B, Khalil, N, Sutherland, D, Smith, W, Horan, G, Assaf, M, Horowitz, Z, Chopra, R, Stevens, RM, Palmisano, M, Janssen-Heininger, YMW & Schafer, PH 2016, 'JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers.', Clin Transl Med, vol. 5, no. 36, pp. 1-18.View/Download from: UTS OPUS or Publisher's site