黄震 - 四川大学 - 生命科学学院

个人简介

简历 1980-1984年，获得四川大学学士学位，分析化学专业 1984-1987年，获得北京大学硕士学位，生物有机化学专业 1988-1994年，获得瑞士苏黎世联邦理工大学（ETH, Zurich) 博士学位，化学生物学专业。 1994-1998年，哈佛大学医学院遗传系博士后, 从师于 2009年诺贝尔医学奖得主邵斯达克教授 (Professor Jack Szostak) 1998年,被聘入纽约城市大学布鲁克伦学院为助理教授 2004年,晋升为副教授，并被聘入乔治亚洲立大学化学系 2009年,晋升为乔治亚洲立大学终身正教授,获大学杰出教授奖，并为美国佐治亚洲癌症研究杰出研究员 2018–今，四川大学生命科学学院正教授其他经验和专业成员 2007–2010 第一任主席（三位创始人之一），中美化学及化学生物学教授协会（CAPA） 2007–今成员，美国癌症研究协会 2006–今成员，美国晶体学协会 2002-2004 主席，美国纽约青年化学家协会（YACS） 1997-1998 主席，美国华人生物化学家协会（ABC），波士顿 1994-今成员，美国化学学会

研究领域

分子生物学，化学生物学，细胞生物学，结构生物学，抗癌分子生物学研究，核酸创新药物和小分子创新药物的发现，病原体和疾病的核酸检测诊断研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Bei Hu, Yitao Wang, Shichao Sun, Weizhu Yan, Chong Zhang, Danyan Luo, Huiling Deng, Lillian R. Hu, Zhen Huang*, “Synthesis of Selenium-triphosphates (dNTPaSe) for morespecific DNA polymerization”, Angew. Chem. Int. Ed., 2019, 58,7835-7839(IF: 12.95). Yiqing Chen, Hehua Liu, Chun Yang, Yanqing Gao, Xiang Yu, Xi Chen, Ruixue Cui, Lina Zheng, Suhua Li, Xuhang Li, Jinbiao Ma, Zhen Huang*, Jixi Li* and Jianhua Gan*, “Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues”, Nature Communications, 2019, 10, 387(IF: 12.12). Xinrui Zhou，Weizhu Yan，Chong Zhang，Zhaoyi Yang，Peter Neubauer，Igor A.Mikhailopulo, Zhen Huang*, Biocatalytic synthesis of seleno-, thio- and chloro-nucleobase modified nucleosides by thermostable nucleoside phosphorylases，Catalysis Communications, 2019.121,32-37(IF: 3.61). Qianwei Zhao, Wen Yang, Tong Qin and Zhen Huang*, “Moonlighting Phosphatase Activity of Klenow DNA Polymerase in the Presence of RNA”, Biochemistry, 2018, 7, 5127-5135(IF: 2.86). Venu Gopal Vandavasi, Matthew P. Blakeley, David A. Keen, Lillian R. Hu, Zhen Huang* and Andrey Kovalevsky*, “Temperature-induced replacement of phosphate proton with metal ion captured in neutron structures of A-DNA”, Structure, 2018, 26, 1-6(IF: 4.86). Hehua Liu, Xiang Yu, Yiqing Chen, Jing Zhang, Baixing Wu , Lina Zheng, Phensinee Haruehanroengra, Rui Wang, Suhua Li, Jinzhong Lin, Jixi Li, Jia Sheng, Zhen Huang*, Jinbiao Ma *& Jianhua Gan*,“Crystal structure of an RNA-cleaving DNAzyme”, NATURE COMMUNICATIONS, 2017.12.08, 8: 2006(IF: 12.12). Yiqing Yiqing Chen, Jing Zhang, Hehua Liu, Yanqing Gao, Xuhang Li, Lina Zheng, Ruixue Cui, Qingqing Yao, Liang Rong, Jixi Li, Zhen Huang*, Jinbiao Ma* and Jianhua Gan*, “Unique 50-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X”, PLoS Biology, 2017, 15, e1002599 (IF: 9.79). Zhang, Liu, et al., Zhen Huang*, Jinbiao Ma*, Jianhua Gan*, “Structural basis for single-stranded RNA recognition and cleavage by C3PO”, Nucleic Acids Research, 2016, 44, 9494–9504（IF:10.1）. Liqin Zhang, Zunyi Yang, Kwame Sefah, Kevin M. Bradley, Shuichi Hoshika, Myong-Jung Kim, Hyo-Joong Kim, Guizhi Zhu, Sena Cansiz, I-Ting Teng, Carole Champanhac, Christopher McLendon, Chen Liu, Wen Zhang, Dietlind L. Gerloff , Zhen Huang*, Weihong Tan* and Steven A. Benner*, “Evolution of Functional Six-Nucleotide DNA”，Journal of American Chemical Society, 2015, 137（21）, 6734−6737 (IF:13.8). Rob Abdur, Oksana O. Gerlits, Jianhua Gan, Jiansheng Jiang, Jozef Salon, Andrey Y. Kovalevsky, Alexander Chumanevich, Irene T. Weber, Zhen Huang*, “Novel Complex MAD Phasing and RNase H Structural Insights by Selenium Oligonucleotides”, Acta Crystallographica Section D, 2014, D70, 354-361. Jia Sheng, Jianhua Gan, Alexie Soars, Jozef Salon and Zhen Huang*, “Structural Insights of Non-canonical U•U Pair and Hoogsteen Interaction Probed with Se Atom”, 2013, Nucleic Acids Research（IF:10.1）, 41(22), 10476-10487. Jia Sheng, Jianhua Gan and Zhen Huang*, “Structure-Based DNA-Targeting Strategies with Small Molecule Ligands for Drug Discovery”, Medicinal Research Reviews, 2013, 33(5), 1119-1173. Huiyan Sun, Sibo Jiang, Julianne Caton-Williams, Hehua Liu, and Zhen Huang*, “2-Selenouridine Triphosphate Synthesis and Se-RNA Transcription”, RNA, 2013, 19(9), 1309-1314. Jia Sheng, Wen Zhang, Abdalla E. A. Hassan, Jianhua Gan, Alexei Soares, Song Geng, Yi Ren, Zhen Huang*, "Hydrogen Bond Formation between the Naturally Modified Nucleobase and Phosphate Backbone", Nucleic Acids Research（IF:10.1）, 2012, 40(16), 8111-8118. Huiyan Sun, Jia Sheng, Abdalla E. A. Hassan, Sibo Jiang, Jianhua Gan and Zhen Huang*, “Novel RNA Base Pair with Higher Specificity using Single Selenium Atom”, Nucleic Acids Res., 2012, 40(11), 5171-5179. Wen Zhang, Jia Sheng, Abdalla E. Hassan, and Zhen Huang*, "Synthesis of Novel 2’-Deoxy-5-(Methylselenyl)Cytidine and Se-DNAs for Structure and Function Studies", Chemistry-An Asian Journal, 2012, 7(3), 476-479. Jia Sheng, Abdalla E. A. Hassan, Wen Zhang, Jianfeng Zhou, Bingqian Xu, Alexei S. Soares and Zhen Huang*, "Synthesis, Structure and Imaging of Oligodeoxyribonucleotides with Tellurium-nucleobase Derivatization", Nucleic Acids Research, 2011, 39(9), 3962-3971. Wen Zhang and Zhen Huang*, "Synthesis of the 5’-Se-Thymidine Phosphoramidite and Convenient Labeling of DNA Oligonucleotide", Organic Letter, 2011, 13(8), 2000-2003. Julianne Caton-Williams, Lina Lin, Mathew Smith, and Zhen Huang*, "Convenient Synthesis of Nucleoside 5’-Triphosphates for RNA Transcription", Chemical Communications, 2011, 47, 8142-8144.