个人简介

University of Calgary, BSc, Biochemistry, 1982 University of Oregon, PhD, Biophysical Chemistry, 1990

研究领域

Our laboratory uses NMR spectroscopy and related biophysical methods to characterize the structure and dynamics of proteins involved in signal transduction and the regulation of gene expression and in the synthesis/degradation of carbohydrates. We receive our funding through the Canadian Cancer Society, the Natural Sciences and Engineering Research Council of Canada, the Canadian Institutes of Health Research, the Canada Foundation for Innovation, and the British Columbia Knowledge Development Fund.

Our laboratory uses NMR spectroscopy and related biophysical methods to characterize the structure and dynamics of proteins involved in signal transduction and the regulation of gene expression and in the synthesis/degradation of carbohydrates.

近期论文

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Conformational dynamics and the binding of specific and non-specific DNA by the autoinhibited transcription factor Ets-1. Desjardins, G., Okon, M., Graves, B.J. and McIntosh, L.P. Biochemistry 55: 4105-4118 (2016) Discovery and characterization of small molecules targeting the ETS factor ERG in prostate cancer. Butler, M.S., Roshan-Moniri1, M., Hsing, M., Lau, D., Kim, A., Yen, P., Mroczek, M., Nouri, M., Lien, S., Axerio-Cilies, P., Dalal, K., Yau, C., Ghaidi, F., Guo, Y., Yamazaki, T., Lawn, S., Gleave, M., Gregory-Evans, C.Y., McIntosh, L.P., Cox, M.E., Rennie, P.S. and Cherkasov, A. submitted (2016) Structured and disordered regions cooperatively autoinhibit the DNA binding of ETV1, ETV4, and ETV5. Currie, S.L., Lau, D.K., Doane, J.J., Whitby, F.G., Okon, M., McIntosh, L.P., and Graves, B.J. in press (2016) Structural and dynamics studies of Pax5 reveal asymmetry in domain stability and DNA binding by the Paired domain. Perez-Borrajero, C., Okon, M., and McIntosh, L.P. J. Mol. Biol. 428: 2372-2391 (2016) Autoinhibition of DNA binding by ETV6 is established by the stability of its inhibitory helix. De, S., Okon, M., Graves, B.J., and McIntosh, L.P. J. Mol. Biol. 424: 1515-1539 (2016) Arginine: Its pKa value revisited. Fitch, C., Platzer, G., Okon, M., Garcia-Moreno, B. and McIntosh, L.P. Protein Science 24: 7525-761 (2015) The modular structure of the inner membrane ring component PrgK facilitates assembly of the type III secretion system basal body. Bergeron, J.R.C., Worrall, L.J., De, S., Sgourakis, N.G., Cheung, A.H., Lameignere, E., Okon, M., Wasney, G., Baker, D., McIntosh, L.P., and Strynadka, N.C.J. Structure 23: 161-172 (2015) pH dependent 1H, 13C, and 15N chemical shifts of the ionizable amino acids: a guide for protein pKa measurements. Platzer, G., Okon, M., and McIntosh, L.P. J. Biomol. NMR 60: 109-129 (2014) (suppl. material) Structural characterization of the C3 domain of cardiac myosin binding protein-C and its hypertrophic cardiomyopathy-related R502W mutant.