个人简介
Organization
2005.04.01 - 2006.09.30, Division of Applied Chemistry, Graduate School of Engineering, Research Assistant
2006.10.01 - 2010.09.30, Frontier Research Base for Global Young Researchers, Graduate School of Engineering, Associate Professor
2010.10.01 - 2011.03.31, Frontier Research Center, Graduate School of Engineering, Associate Professor
2011.04.01 - 2013.03.31, Science and Technology Center for Atoms,Molecules and Ions Control, Graduate School of Engineering, Associate Professor
2013.04.01 - 2013.04.15, Center for Atomic and Molecular Technologies, Graduate School of Engineering, Associate Professor
2013.04.16 - 2017.03.31, Center for Atomic and Molecular Technologies, Graduate School of Engineering, Associate Professor
2017.04.01 - , Division of Applied Chemistry, Graduate School of Engineering, Professor
Education
Osaka University Faculty of Engineering Graduated 1996.03
Osaka University Graduate School, Division of Engineering Completed 1998.03
Osaka University Graduate School, Division of Engineering Completed 2001.03
Employment Record
Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, Associate Professor 2011.04 - 2017.03
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Professor 2017.04 -
研究领域
Discovering New Chemical Reactions
From pharmaceuticals to liquid crystals, organic compounds exist everywhere. It is the molecular structure of a compound that determines its properties and functions. Thus, it is clear that chemical reactions play an essential role in the creation of new functional molecules as a means for constructing sophisticated molecular architectures. Organic chemistry textbooks have taught that a significant number of chemical reactions have already been developed to date. Are there any reasons for us to develop new reactions? The answer should be YES. The emergence of new chemical reactions that, not only replace existing chemical processes with more environmentally-benign and energy-saving ones, but also lead to the assembly of molecules that are otherwise inaccessible continue to be needed. The importance of this research was recognized by the awarding of the Nobel Prize in chemistry, even in the 21st century, for research leading to new chemical reactions, such as asymmetric hydrogenation and oxidation, metathesis, and cross-coupling. These new reactions have enabled the synthesis of a series of chiral molecules, polymers and ?-conjugated compounds that had never existed.
The research objectives of our group include the development of such new chemical reactions. Our policy is to explore truly unknown reactivities, rather than modifying or improving existing methods. Our goal is to discover reactions whose mechanism cannot be understood at first glance. In other words, we are attempting to explore reactions out of the realm of current reaction theories. The discovery of new chemical reactions has the potential to revolutionize our society, which motivates us to pursue these challenging projects in our laboratory.
Designing New Reactions
We employ transition-metal complexes as a reliable tool for inventing new chemical reactions. The introduction of transition-metal catalyzed reactions, as represented by cross-coupling and metathesis, during the past several decades have resulted in a tremendous advance in the field of chemical synthesis. However, it should be noted that there is still much room for discovering new reactivities of transition-metal complexes, since a virtually unlimited number of catalysts can be produced by a combination of a number of transition metals and a diverse array of ligands, and their reactivities promise to be infinite. Unfortunately, the theories for metal-catalyzed reactions are not sufficiently matured to permit the complete design of a new reaction and to predict the outcome. However, this infancy allows for experimentalists to approach such issues using their creativity and imagination. We have attempted to design catalysts, ligands, substrates and reagents by building a rather risky yet rewarding hypothesis. We also designed catalytic cycles by designing a balanced combination of elementary steps that shape the catalytic reactions. Designing a new elementary step is also a subject of interest in our group. These designs frequently do not work as well as expected. However, new reactions can eventually be developed by continuous efforts to polish the reaction designs or to completely revise the design of such processes by virtue of serendipitous findings.
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
Single–carbon atom transfer to α,β-unsaturated amides from N-heterocyclic carbenes Miharu Kamitani, Bunta Nakayasu, Hayato Fujimoto, Kosuke Yasui, Takuya Kodama, and Mamoru Tobisu Science, 2023, 379(6631), 336–340.
Synthesis, Structure, and Reactivity of a Gallylene Derivative Bearing a Phenalenyl-Based Ligand Takuya Kodama, Nijito Mukai, and Mamoru Tobisu ChemRxiv, 2023, DOI:10.26434/chemrxiv-2023-jkhx3-v2
1,2-Diacylation of Alkynes Using Acyl Fluorides and Acylsilanes by P(III)/P(V) Catalysis Hayato Fujimoto, Shisato Yamamura, Momoka Kusano, and Mamoru Tobisu Org. Lett., 2023, 25(2), 336–340.
Monovalent Germanium Radical Stabilized by a Phenalenyl Scaffold Takuya Kodama, Kenta Uchida, Chihiro Nakasuji, Ryohei Kishi,Yasutaka Kitagawa, and Mamoru Tobisu ChemRxiv, 2022, DOI:10.26434/chemrxiv-2022-z0f7j
Nickel-Catalyzed Cross Coupling via C–O and C–N Activation Tomoki Yoshida and Mamoru Tobisu Science of Synthesis: Base-Metal Catalysis, 2022, 1, 591–630.
Zn(II)-catalyzed Formal Cross-Dimerization of Carbenes Using Acylsilanes and Diazo Esters Tomoki Yoshida, Masaya Ohta, Tomoya Emmei, Takuya Kodama, and Mamoru Tobisu Chem. Lett., 2022, 52(1), 48–50.
Rhodium-catalyzed Decarbonylation of Acylsilanes Tomoki Yoshida, Takuya Kodama, and Mamoru Tobisu Asian J. Org. Chem., 2022, 11(12), e202200610. (Invited contribution to the special collection on the occasion of Professor Keiji Maruoka's 70th birthday)
Pd-catalyzed siloxycyclopropanation of alkenes Shun Sakurai, Tetsuya Inagaki, Takuya Kodama, Masahiro Yamanaka, and Mamoru Tobisu Trends in Chemistry, 2022, 4(12), 1161–1162. (Invited contribution to 'Mechanism of the Month')
Phosphine-Catalyzed Z-Selective Carbofluorination of Alkynoates Bearing an N-Heteroarene Units Hayato Fujimoto, Shisato Yamamura, Namiki Takenaka, and Mamoru Tobisu Synthesis, 2022, in press (Invited contribution to the special issue on 'Synthetic Advancements Enabled by Phosphorus Redox Chemistry')
Synthetic Applications of C–O and C–E Bond Activation Reactions Mamoru Tobisu, Takuya Kodama and Hayato Fujimoto In Comprehensive Organometallic Chemistry IV, 2022, 12, pp347–420.
Nickel-catalyzed 1,4-aryl rearrangement of aryl N-benzylimidates via C–O and C–H bond cleavage Satoshi Ogawa and Mamoru Tobisu Chem. Commun., 2022, 58(57), 7909–7911.
Palladium-Catalyzed Unimolecular Fragment Coupling of N-Allylamides via Elimination of Isocyanate Ryoma Shimazumi, Riku Tanimoto, Takuya Kodama, and Mamoru Tobisu J. Am. Chem. Soc., 2022, 144(24), 11033–11043.
Non-Stabilized Vinyl Anion Equivalents from Styrenes by N-Heterocyclic Carbene Catalysis and Its Use in Catalytic Nucleophilic Aromatic Substitution Sora Ito, Hayato Fujimoto, and Mamoru Tobisu J. Am. Chem. Soc., 2022, 144(15), 6714–6718.
Nickel-Catalyzed Skeletal Transformation of Tropone Derivatives via C–C Bond Activation: Catalyst-Controlled Access to Diverse Ring Systems Takuya Kodama, Kanako Saito, and Mamoru Tobisu Chem. Sci., 2022, 13(17), 4922–4929.
Palladium-Catalyzed Silylacylation of Allenes Using Acylsilanes Tetsuya Inagaki, Shun Sakurai, Masahiro Yamanaka, and Mamoru Tobisu Angew. Chem. Ind. Ed., 2022, 61(21), e202202387.
Overlooked Factors Required for Electrolyte Solvents in Li–O₂ Batteries: Capabilities of Quenching 1O₂ and Forming Highly-Decomposable Li₂O₂ Kiho Nishioka, Mizuki Tanaka, Hayato Fujimoto, Toru Amaya, Sensuke Ogoshi, Mamoru Tobisu, and Shuji Nakanishi Angew. Chem. Ind. Ed., 2022, 61(12), e202112769.
Ratiometric and colorimetric detection of Cu2+ via the oxidation of benzodihydroquinoline derivatives and related synthetic methodology Waroton Paisuwan, Vachiraporn Ajavakom, Mongkol Sukwattanasinitt, Mamoru Tobisu, Anawat Ajavakom Sens. Bio-Sens. Res., 2022, 35, 100470.
京公网安备 11010802027423号