Rabinowitz, Joshua - Princeton University

研究领域

Biochemical kinetics/cellular metabolism/chemical basis of complex biological processes. Joint appointment with the Lewis-Sigler Institute for Integrative Genomics.

近期论文

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Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka,E., Vander Heiden, M. G., Miller, G., Drebin, J. A., Bar-Sagi, D., Thompson, C. B., Rabinowitz, J. D. (2015) Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res., 75(3): 544-53. Ducker, G. S. and Rabinowitz, J. D. (2015) ZMP: A master regulator of one-carbon metabolism. Mol. Cell, 57(2): 203-4. Xu, Y. F., Lu, W., Rabinowitz, J. D. (2015) Avoiding misannotation of in-source fragmentation products as cellular metabolites in liquid chromatography-mass spectrometry-based metabolomes. Anal. Chem., 2015 Jan 27 [Epub ahead of print] Aristilde, L., Lewis, I. A., Park, J. O., Rabinowitz, J. D. (2014) Hierarchy in pentose sugar metabolism in clostridium acetobutylicum. Appl. Environ. Microbiol., pii: AEM.03199-14. Hwang, J., Purdy, J. G., Wu, K., Rabinowitz, J. D., Shenk, T. (2014) Estrogen-related receptor α is required for efficient human cytomegalovirus replication. Proc. Natl. Acad. Sci. USA, 111(52): E5706-17. Kamphorst, J. J., Chung, M. K., Fan, J., Rabinowitz, J. D. (2014) Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer & Metabolism, 2: 23. Fan, J., Teng, X., Liu, L., Mattaini, K. R., Looper, R. E., Vander Heiden, M. G., Rabinowitz, J. D. (2014) Human phosphoglycerate dehydrogenase produces the oncometabolite d-2-hydroxyglutarate. ACS Chem Biol., 2014 Nov. 18. Epub ahead of print. Castellana, M., Wilson, M. Z., Xu, Y., Joshi, P., Cristea, I. M., Rabinowitz, J. D., Gitai, Z., Wingreen, W. S. (2014) Enzyme clustering accelerates processing of intermediates through metabolic channeling. Nat. Biotechnol., 32(10): 1011-8. Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M., Campbell, K., Cheung, E., Olin-Sandoval, V., Gruening, N. M., Krueger, A., Tauqeer Alam, M., Keller, M. A., Breitenbach, M., Brindle, K. M., Rabinowitz, J. D., Raiser, M. (2014) The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol. Rev. Camb. Philos. Soc., 2014 Sep 22. Epub ahead of print. Zhang, J., Fan, J., Venneti, S., Cross, J. R., Takagi, T., Bhinder, B., Djaballah, H., Kanai, M., Cheng, E. H., Judkins, A. R., Pawel, B., Baggs, J., Cherry, S., Rabinowitz, J. D., Thompson, C. B. (2014) Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Mol. Cell, 56(2): 205-18. Ye, J., Fan, J., Venneti, S., Wan, Y. W., Pawel, B. R., Zhang, J., Finley, L. W., Lu, C., Linsten, T., Cross, J., Qing, G., Liu, Z., Simon, M. C., Rabinowitz, J. D., Thompson, C. (2014) Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov., 4(12): 1406-17. Mathew, R., Khor, S., Hackett, S. R., Rabinowitz, J. D., Perlman, D. H., White, E. (2014) Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity. Mol. Cell, 55(6): 916-30. Karsli-Uzunbas, G., Guo, J. Y., Price, S. M., Teng, X., Laddha, S. V., Khor, S., Kalaany, N. Y., Jacks, T., Chan, C. S., Rabinowitz, J. D., White, E. (2014) Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov., 4(8): 914-27. Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., Rabinowitz, J. D. (2014) Quantitative flux analysis reveals folate-dependent NADPH production. Nature, 510(7504): 298-302. Breunig, J. S., Hackett, S. R., Rabinowitz, J. D., Krugkyak, L. (2014) Genetic basis of metabolome variation in yeast. PLoS Genet., 10(3): e1004142. Shlomi, T., Fan, J., Tang, B., Kruger, W. D., Rabinowitz, J. D. (2014) Quantitation of cellular metabolic fluxes in methionine. Anal. Chem., 86(3): 1583-91. Kliegman, J. I., Fiedler, D., Ryan, C. J., Xu, Y. F., Su, X. Y., Thomas, D., Caccese, M. C., Cheng, A., Shales, M., Rabinowitz, J. D., Krogan, N. J., Shokat, K. M. (2013) Chemical genetics of rapamycin-insensitive TORC2 in s. cerevisiae. Cell Rep., 5(6): 1725-36. Fan, J., Kamphorst, J. J., Mathew, R., Chung, M. K., White, E., Shlomi, T., Rabinowitz, J. D. (2013) Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol. Syst. Biol., 9: 712. Grady, S. L., Purdy, J. G., Rabinowitz, J. D., Shenk, T. (2013) Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection. Proc. Natl. Acad. Sci. USA, 110(51): E5006-15. Tchigvintsev, A., Tchigvintsev, D., Flick, R., Popovic, A., Dong, A., Xu, X., Brown, G., Lu, W., Wu, H., Dombrowski, L., Joo, J. C., Beloglazova, N., Min, J., Savchenko, A., Caudy, A. A., Rabinowitz, J. D., Murin, A. G., Yakunin, A. F. (2013) Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides.Chem. Biol., 20(11): 1386-98.