个人简介

B.Sc., Concordia - Canada Scholar (Nick Serpone, 1993) Ph.D., Stanford - NSERC Centennial Scholar (Edward I Solomon, 2002) PDF, Caltech (Harry B Gray & Adrian Ponce, 2002-3)

研究领域

Biological & Medicinal Chemistry; Catalytic Processes; Inorganic Chemistry; Molecular Spectroscopy; Physical & Theoretical Chemistry

My research centres on probing the relationship between electronic structure and reactivity in catalytic systems. Emphasis is placed on the application of element-specific spectroscopic techniques such as X-ray Absorption Spectroscopy (XAS) and X-ray Emission Spectroscopy (XES) as a means of generating experimentally-validated electronic and geometric structure descriptions of catalytically relevant species. ​ Recent investigations by Thamy Sriskandakumar, in collaboration with Prof Peter J. Sadler and members of his group provided new insights into the possible mechanism of action of a series of potent cytotoxic ruthenium(II) arene complexes of interest as potential anticancer drugs. (see J. Am. Chem. Soc. 2009, 131(37), 13355–13361) Other spectroscopic techniques (such as UV/Vis/NIR Absorption and EPR), as well as computational methods, are used as complementary methods to explore such species. We have varied interests in a number of areas spanning bioinorganic, organometallic, and physical inorganic chemistry. Specific projects are (as much as possible) tailored to the specific interests and strengths of students.

近期论文

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Chen, P. ; Gamelin, D. R. ; Kennepohl, P. Preface. Coord. Chem. Rev. 2013, 257, 1–2.BibTex Keske, E. C. ; Zenkina, O. V. ; Asadi, A. ; Sun, H. ; Praetorius, J. M. ; Allen, D. P. ; Covelli, D. ; Patrick, B. O. ; Wang, R. ; Kennepohl, P. ; James, B. R. ; Crudden, C. M. Dioxygen Adducts Of Rhodium N-Heterocyclic Carbene Complexes. Dalton Trans. 2013, 42, 7414–23.BibTex Xue, W. ; Kennepohl, P. ; Ruddick, J. N. R. Quantification Of Mobilized Copper(Ii) Levels In Micronized Copper-Treated Wood By Electron Paramagnetic Resonance (Epr) Spectroscopy. Holzforschung 2013, in press, 1–9.BibTex 2012 Cipot-Wechsler, J. ; Covelli, D. ; Praetorius, J. M. ; Hearns, N. ; Zenkina, O. V. ; Keske, E. C. ; Wang, R. ; Kennepohl, P. ; Crudden, C. M. Synthesis And Characterization Of Cationic Rhodium Peroxo Complexes. Organometallics 2012, 31, 7306–7315.BibTex Rueda-Becerril, M. ; Sazepin, C. Chatalova; Leung, J. Cho Tak; Okbinoglu, T. ; Kennepohl, P. ; Paquin, J. - F. ; Sammis, G. M. Fluorine Transfer To Alkyl Radicals. J. Am. Chem. Soc. 2012, 134, 4026–9.BibTex Xue, W. ; Kennepohl, P. ; Ruddick, J. N. R. Investigation Of Copper Solubilization And Reaction In Micronized Copper Treated Wood By Electron Paramagnetic Resonance ( Epr ) Spectroscopy. Holzforschung 2012, 66, 889–895.BibTex 2011 Martin-Diaconescu, V. ; Perepichka, I. ; D Bohle, S. ; Kennepohl, P. Electronic Structure Of S -Nitrosothiols From Sulfur K-Edge X-Ray Absorption Spectroscopy. Can. J. Chem. 2011, 89, 93–97.BibTex 2010 Delgado-Jaime, M. Ulises; Kennepohl, P. Development And Exploration Of A New Methodology For The Fitting And Analysis Of Xas Data. Journal of synchrotron radiation 2010, 17, 119–28.BibTex Delgado-Jaime, M. Ulises; Mewis, C. Philip; Kennepohl, P. Blueprint Xas: A Matlab-Based Toolbox For The Fitting And Analysis Of Xas Spectra. J. Syncr. Rad. 2010, 17, 132–7.BibTex 2009 Bates, J. €I. ; Kennepohl, P. ; Gates, D. P. Abnormal Reactivity Of An N-Heterocyclic Carbene (Nhc) With A Phosphaalkene: A Route To A 4-Phosphino-Substituted Nhc. Angew. Chem. Int. Ed. 2009, 48, 9844–9847.BibTex Kennepohl, P. ; Wasinger, E. C. ; George, S. DeBeer X-Ray Spectroscopic Approaches To The Investigation And Characterization Of Photochemical Processes. J. Syncr. Rad. 2009, 16, 484–8.BibTex Martin-Diaconescu, V. ; Kennepohl, P. Effects Of Hyperconjugation On The Electronic Structure And Photoreactivity Of Organic Sulfonyl Chlorides. Inorg. Chem. 2009, 48, 1038–44.BibTex Sriskandakumar, T. ; Petzold, H. ; Bruijnincx, P. C. A. ; Habtemariam, A. ; Sadler, P. J. ; Kennepohl, P. Influence Of Oxygenation On The Reactivity Of Ruthenium-Thiolato Bonds In Arene Anticancer Complexes: Insights From Xas And Dft. J. Am. Chem. Soc. 2009, 131, 13355–61.BibTex Karunakaran-Datt, A. ; Kennepohl, P. Redox Photochemistry Of Methionine By Sulfur K-Edge X-Ray Absorption Spectroscopy: Potential Implications For Cataract Formation. J. Am. Chem. Soc. 2009, 131, 3577–82.BibTex 2008 Praetorius, J. M. ; Allen, D. P. ; Wang, R. ; Webb, J. D. ; Grein, F. ; Kennepohl, P. ; Crudden, C. M. N-Heterocyclic Carbene Complexes Of Rh: Reaction With Dioxygen Without Oxidation. J. Am. Chem. Soc. 2008, 130, 3724–5.BibTex Getty, K. ; Delgado-Jaime, M. Ulises; Kennepohl, P. Assignment Of Pre-Edge Features In The Ru K-Edge X-Ray Absorption Spectra Of Organometallic Ruthenium Complexes. Inorg. Chim. Acta 2008, 361, 1059.BibTex 2007 Martin-Diaconescu, V. ; Kennepohl, P. Sulfur K-Edge Xas As A Probe Of Sulfur-Centered Radical Intermediates. J. Am. Chem. Soc. 2007, 129, 3034–5.BibTex Getty, K. ; Delgado-Jaime, M. Ulises; Kennepohl, P. An Electronic Rationale For Observed Initiation Rates In Ruthenium-Mediated Olefin Metathesis: Charge Donation In Phosphine And N-Heterocyclic Carbene Ligands. J. Am. Chem. Soc. 2007, 129, 15774–6.BibTex Gilroy, J. B. ; McKinnon, S. D. J. ; Kennepohl, P. ; Zsombor, M. S. ; Ferguson, M. J. ; Thompson, L. K. ; Hicks, R. G. Probing Electronic Communication In Stable Benzene-Bridged Verdazyl Diradicals. J. Org. Chem. 2007, 72, 8062–8069.BibTex 2006 Delgado-Jaime, M. Ulises; Conrad, J. C. ; Fogg, D. E. ; Kennepohl, P. X-Ray Absorption Methods For The Determination Of Ru–Cl Bond Covalency In Olefin Metathesis Catalysts: On The Normalization Of Chlorine K-Edges In Ruthenium Complexes. Inorg. Chim. Acta 2006, 359, 3042–3047.BibTex 2005 Solomon, E. I. ; Basumallick, L. ; Chen, P. ; Kennepohl, P. Variable Energy Photoelectron Spectroscopy: Electronic Structure And Electronic Relaxation. Coord. Chem. Rev. 2005, 249, 229–253.BibTex Kennepohl, P. ; Neese, F. ; Schweitzer, D. ; Jackson, H. L. ; Kovacs, J. A. ; Solomon, E. I. Spectroscopy Of Non-Heme Iron Thiolate Complexes: Insight Into The Electronic Structure Of The Low-Spin Active Site Of Nitrile Hydratase. Inorg. Chem. 2005, 44, 1826–36.BibTex