Zuo, Yi - University of California, Santa Cruz - Molecular, Cell & Developmental Biology Faculty

研究领域

My laboratory studies how the neuronal circuitry rewires during learning and memory formation, particularly in the motor system. We combine vital imaging, molecular manipulation, circuitry tracing and behavioral analysis to investigate the cellular mechanisms underlying synapse plasticity in both physiological and pathological conditions.. My laboratory can be found at UCSC's Dept. of Molecular, Cell and Developmental Biology. The lab is relatively small (typically 8-10 members) and includes postdoctoral, graduate and undergraduate researchers. The University also offers a wide range of shared instrumentation facilities, as well as opportunities for exciting interdisciplinary collaborations.

近期论文

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Preferential stabilization of newly formed dendritic spines in motor cortex during manual skill learning predicts performance gains, but not memory endurance. Clark TA, Fu M, Dunn AK, Zuo Y, Jones TA. Neurobiol Learn Mem. 2018 Jul;152:50-60. doi: 10.1016/j.nlm.2018.05.005. Epub 2018 May 17. Pyramidal Neurons in Different Cortical Layers Exhibit Distinct Dynamics and Plasticity of Apical Dendritic Spines. Tjia M, Yu X, Jammu LS, Lu J, Zuo Y. Front Neural Circuits. 2017 Jun 19;11:43. doi: 10.3389/fncir.2017.00043. eCollection 2017. Astrocytic Contributions to Synaptic and Learning Abnormalities in a Mouse Model of Fragile X Syndrome. Hodges JL, Yu X, Gilmore A, Bennett H, Tjia M, Perna JF, Chen CC, Li X, Lu J, Zuo Y. Biol Psychiatry. 2017 Jul 15;82(2):139-149. doi: 10.1016/j.biopsych.2016.08.036. Epub 2016 Sep 13. [Fibrosis after damage to fat dome structure of skin of pig]. Yu X, Kang Y, Zuo Y, Liu C, Ye J, Yuan B, Ji X, Song F, Jiang Y, Xiao Y, Jin S, Lu S. Zhonghua Shao Shang Za Zhi. 2015 Oct;31(5):349-53. Chinese. Neutralization of Nogo-A enhances synaptic plasticity in the rodent motor cortex and improves motor learning in vivo. Zemmar A, Weinmann O, Kellner Y, Yu X, Vicente R, Gullo M, Kasper H, Lussi K, Ristic Z, Luft AR, Rioult-Pedotti M, Zuo Y, Zagrebelsky M, Schwab ME. J Neurosci. 2014 Jun 25;34(26):8685-98. doi: 10.1523/JNEUROSCI.3817-13.2014. Accelerated experience-dependent pruning of cortical synapses in ephrin-A2 knockout mice. Yu X, Wang G, Gilmore A, Yee AX, Li X, Xu T, Smith SJ, Chen L, Zuo Y. Neuron. 2013 Oct 2;80(1):64-71. doi: 10.1016/j.neuron.2013.07.014. Epub 2013 Oct 2. Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo. Fu M, Yu X, Lu J, Zuo Y. Nature. 2012 Feb 19;483(7387):92-5. doi: 10.1038/nature10844. Spatial constraints dictate glial territories at murine neuromuscular junctions. Brill MS, Lichtman JW, Thompson W, Zuo Y, Misgeld T. J Cell Biol. 2011 Oct 17;195(2):293-305. doi: 10.1083/jcb.201108005.