Sullivan, William - University of California, Santa Cruz - Molecular, Cell & Developmental Biology Faculty

个人简介

B.A., University of California, San Diego Ph.D., University of Washington, Seattle Postdoctorate, University of California, San Francisco

研究领域

Cell Cycle, Cytoskeleton and Pathogenesis The Sullivan lab focuses on the structural and regulatory mechanisms that drive cell division. Much of our recent efforts have been directed toward understanding the mechanisms that drive furrow ingression during cytokinesis and how this process is coordinated with chromosome segregation and other mitotic events. Through a combination of molecular genetic and cellular approaches, the Sullivan Group has found that elongation of the cytokinesis furrow involves vesicle mediated mediated membrane addition from the recycling endosome. The vesicles not only supply the membrane, but also bring potent actin remodelers to the site of furrow formation. These results provide insight into the mechanisms by which membrane addition is coordinated with acto-myosin based contraction of the furrow. The Sullivan laboratory's current efforts are focused on: 1) the role of vesicle-mediated membrane addition in controlling the timing and position of furrow formation, 2) the mechanisms that recruit F-actin to the cleavage furrow, and 3) identifying the signaling pathways that drives the cell cycle-regulated membrane addition to the furrow. A second research interest of the lab is the identification of the molecular and cellular basis of host/pathogen interactions. Part of the research group focuses on Wolbachia, obligate intracellular bacterial endosymbionts that are present in over 60% of all insect species. Manipulation of host reproduction and efficient maternal transmission has facilitated the global spread of Wolbachia in arthropods. Wolbachia are also present in worms, and are the leading cause of human blindness in Southern Africa, due the inflammatory response upon release from Wolbachia's nematode host, Onchocerca volvulus. The lab's long-term objective is to understand how Wolbachia use and manipulate host cell processes to their advantage. Specifically, they are interested in Wolbachia/host molecular and cellular interactions that mediate Wolbachia transmission during mitosis in the female germline and somatic tissues. They are also identifying the mechanisms that regulate Wolbachia replication in host cells. Finally, the lab has developed high-throughout cell-based assays to identify more potent Wolbachia-specific antibiotics to be used in the fight against African River Blindness.

近期论文

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Wolbachia and host germline components compete for kinesin-mediated transport to the posterior pole of the Drosophila oocyte. Russell SL, Lemseffer N, White PM, Sullivan WT. PLoS Pathog. 2018 Aug 15;14(8):e1007216. doi: 10.1371/journal.ppat.1007216. eCollection 2018 Aug. Erratum in: PLoS Pathog. 2019 Jan 30;15(1):e1007557. Micronuclei Formation Is Prevented by Aurora B-Mediated Exclusion of HP1a from Late-Segregating Chromatin in Drosophila. Warecki B, Sullivan W. Genetics. 2018 Sep;210(1):171-187. doi: 10.1534/genetics.118.301031. Epub 2018 Jul 9. Wolbachia, bottled water, and the dark side of symbiosis. Sullivan W. Mol Biol Cell. 2017 Sep 1;28(18):2343-2346. doi: 10.1091/mbc.E17-02-0132. The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation. Karg T, Elting MW, Vicars H, Dumont S, Sullivan W. J Cell Biol. 2017 Jun 5;216(6):1597-1608. doi: 10.1083/jcb.201604079. Epub 2017 May 12. Polo kinase mediates the phosphorylation and cellular localization of Nuf/FIP3, a Rab11 effector. Brose L, Crest J, Tao L, Sullivan W. Mol Biol Cell. 2017 Jun 1;28(11):1435-1443. doi: 10.1091/mbc.E16-04-0236. Epub 2017 Apr 5. Microbiology: Manipulation of the manipulators. Sullivan W, O'Neill SL. Nature. 2017 Mar 9;543(7644):182-183. doi: 10.1038/nature21509. Epub 2017 Feb 26. No abstract available. Reliance of Wolbachia on High Rates of Host Proteolysis Revealed by a Genome-Wide RNAi Screen of Drosophila Cells. White PM, Serbus LR, Debec A, Codina A, Bray W, Guichet A, Lokey RS, Sullivan W. Genetics. 2017 Apr;205(4):1473-1488. doi: 10.1534/genetics.116.198903. Epub 2017 Feb 3. Mechanisms of Horizontal Cell-to-Cell Transfer of Wolbachia spp. in Drosophila melanogaster. White PM, Pietri JE, Debec A, Russell S, Patel B, Sullivan W. Appl Environ Microbiol. 2017 Mar 17;83(7). pii: e03425-16. doi: 10.1128/AEM.03425-16. Print 2017 Apr 1.