Strome, Susan - University of California, Santa Cruz - Molecular, Cell & Developmental Biology Faculty

个人简介

B.A., University of New Mexico, Albuquerque Ph.D., University of Washington, Seattle Postdoctorate, University of Colorado, Boulder

研究领域

Regulation of Germ Cell Development in C. elegans Germ cells (the cells that give rise to eggs and sperm) have special properties. Their immortality allows them to be perpetuated from generation to generation, and their totipotency allows them to generate all of the diverse cell types of the body in each generation. Our lab investigates the molecular mechanisms used by germ cells to establish and maintain their identity, immortality, and totipotency. We study germ cells in the model organism C. elegans using a wide variety of approaches, including genetics, imaging, molecular biology, biochemistry, and whole-genome microarray and sequencing technologies. Our current focus areas are transmission of chromatin states and control of gene expression in germ cells, and regulation of RNA metabolism by germline-specific cytoplasmic "P granules". Chromatin regulation: The MES proteins are histone methylating enzymes that are essential for germ cell identity and immortality. MES-4 and its H3Lys36 methyl marks are dramatically concentrated on the autosomes, while MES-2/3/6-catalyzed H3Lys27 methyl marks are preferentially on the X chromosomes. We are investigating how the MES proteins achieve their distinct distributions, how their patterns are transmitted across generations and through DNA replication, how they regulate gene expression and silencing of the X chromosomes in germ cells, and how they participate in specifying germ cell identity and instructing proper germ cell development. P granule regulation: P granules are germline-specific RNA-protein complexes that overlie nuclear pores and extend the nuclear pore complex environment. We recently learned that P granules protect germ cell fate by antagonizing somatic cell fate. We are investigating the molecular basis for that role.

近期论文

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Repression of Germline Genes in Caenorhabditis elegans Somatic Tissues by H3K9 Dimethylation of Their Promoters. Rechtsteiner A, Costello ME, Egelhofer TA, Garrigues JM, Strome S, Petrella LN. Genetics. 2019 Mar 25. pii: genetics.301878.2018. doi: 10.1534/genetics.118.301878. [Epub ahead of print] Sperm-inherited H3K27me3 impacts offspring transcription and development in C. elegans. Kaneshiro KR, Rechtsteiner A, Strome S. Nat Commun. 2019 Mar 20;10(1):1271. doi: 10.1038/s41467-019-09141-w. Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis. Tabuchi TM, Rechtsteiner A, Jeffers TE, Egelhofer TA, Murphy CT, Strome S. Nat Commun. 2018 Oct 17;9(1):4310. doi: 10.1038/s41467-018-06236-8. Distinct Roles of Two Histone Methyltransferases in Transmitting H3K36me3-Based Epigenetic Memory Across Generations in Caenorhabditis elegans. Kreher J, Takasaki T, Cockrum C, Sidoli S, Garcia BA, Jensen ON, Strome S. Genetics. 2018 Nov;210(3):969-982. doi: 10.1534/genetics.118.301353. Epub 2018 Sep 14. Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes. Goetsch PD, Garrigues JM, Strome S. PLoS Genet. 2017 Nov 1;13(11):e1007088. doi: 10.1371/journal.pgen.1007088. eCollection 2017 Nov. Correction: A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans. Ahn JH, Rechtsteiner A, Strome S, Kelly WG. PLoS Genet. 2017 May 31;13(5):e1006821. doi: 10.1371/journal.pgen.1006821. eCollection 2017 May. Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult Caenorhabditis elegans Germline. Knutson AK, Egelhofer T, Rechtsteiner A, Strome S. Genetics. 2017 May;206(1):163-178. doi: 10.1534/genetics.116.198549. Epub 2017 Mar 3. Inheritance of protection from osmotic stress. Kaneshiro KR, Strome S. Nat Cell Biol. 2017 Mar 1;19(3):151-152. doi: 10.1038/ncb3483.