Saxton, Bill - University of California, Santa Cruz - Molecular, Cell & Developmental Biology Faculty

个人简介

B.S., Microbiology, University of Minnesota Ph.D., Molecular, Cell and Developmental Biology, University of Colorado, Boulder

研究领域

Organelle Transport and Neurodegeneration The Saxton lab studies mechanisms that drive intracellular transport and cytoplasmic organization, using Drosophila as a model organism. To generate and maintain proper cytoplasmic order and thus their complex functions, cells use microtubules and force-generating motor proteins to transport RNAs, proteins, mitochondria and other organelles to appropriate locations. Neurons are especially dependent on such microtubule-based cytoplasmic transport, because their signaling functions rely on extraordinarily long cytoplasmic extensions (axons and dendrites) that require import of many components from their cell bodies. Defects in microtubule-based transport can cause or contribute to Alzheimer's, ALS, SBMA, spastic paraplegia and other neurodegenerative diseases. We are currently focusing on how motor proteins accomplish their normal transport jobs in neurons and oocytes, and on identifying the cellular mechanisms that link defective transport to axon degeneration in our Drosophila spastic paraplegia model system. Our strategies usually begin with genetic screens, candidate gene perturbations, or chemical tests of microtubule-based transport processes, looking for specific motor-cargo interactions and ways to control those interactions. A central part of or analyses includes developing methods for high resolution tracking and quantification of single organelle movements in oocytes, neurons, and glial cells in live animals or tissues.

近期论文

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Two kinesins drive anterograde neuropeptide transport. Lim A, Rechtsteiner A, Saxton WM. Mol Biol Cell. 2017 Nov 15;28(24):3542-3553. doi: 10.1091/mbc.E16-12-0820. Epub 2017 Sep 13. A Mechanism for Cytoplasmic Streaming: Kinesin-Driven Alignment of Microtubules and Fast Fluid Flows. Monteith CE, Brunner ME, Djagaeva I, Bielecki AM, Deutsch JM, Saxton WM. Biophys J. 2016 May 10;110(9):2053-65. doi: 10.1016/j.bpj.2016.03.036. Kinesin-1 tail autoregulation and microtubule-binding regions function in saltatory transport but not ooplasmic streaming. Moua P, Fullerton D, Serbus LR, Warrior R, Saxton WM. Development. 2016 Apr 1;143(7):1228. doi: 10.1242/dev.136747. No abstract available. Three routes to suppression of the neurodegenerative phenotypes caused by kinesin heavy chain mutations. Djagaeva I, Rose DJ, Lim A, Venter CE, Brendza KM, Moua P, Saxton WM. Genetics. 2012 Sep;192(1):173-83. doi: 10.1534/genetics.112.140798. Epub 2012 Jun 19. The axonal transport of mitochondria. Saxton WM, Hollenbeck PJ. J Cell Sci. 2012 May 1;125(Pt 9):2095-104. doi: 10.1242/jcs.053850. Epub 2012 May 22. Review. Kinesin-1 tail autoregulation and microtubule-binding regions function in saltatory transport but not ooplasmic streaming. Moua P, Fullerton D, Serbus LR, Warrior R, Saxton WM. Development. 2011 Mar;138(6):1087-92. doi: 10.1242/dev.048645. Epub 2011 Feb 9. Erratum in: Development. 2016 Apr 1;143(7):1228. Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides. Barkus RV, Klyachko O, Horiuchi D, Dickson BJ, Saxton WM. Mol Biol Cell. 2008 Jan;19(1):274-83. Epub 2007 Nov 7. Control of a kinesin-cargo linkage mechanism by JNK pathway kinases. Horiuchi D, Collins CA, Bhat P, Barkus RV, Diantonio A, Saxton WM. Curr Biol. 2007 Aug 7;17(15):1313-7. Epub 2007 Jul 19.