Kim, Euiseok - University of California, Santa Cruz - Molecular, Cell & Developmental Biology Faculty

个人简介

B.S., Yonsei University, Seoul, Korea Ph.D., University of Texas, Southwestern Medical Center at Dallas, TX Postdoctorate, The Salk Institute for Biological Studies and UC San Diego, La Jolla, CA

研究领域

Development, Connectivity, and Genetic Identity of Cortical Circuits The mammalian cortex is composed of numerous functionally specialized areas. Interactions between these areas, mediated by widespread yet precise cell type specific circuits, are central to the neural computations that generate perception, cognition, and behavior, and make us who we are. Since circuit-level understanding of this brain-wide neural network will elucidate fundamentals of the human mind and behavior, my laboratory focuses on understanding the organizational logic of long-distance cortical circuits and the molecular mechanisms of their development using mouse visual cortex as a model. In the mature brain, what are the connectivity and functional bases of neural circuits at the cellular level? Using novel trans-synaptic tracers and in vivo imaging, we are investigating the identities of brain-wide input and output neurons and their functional contributions to information processing. In the developing brain, what are the mechanisms that match gene expression to neuronal connectivity? It is unknown how a population of neural progenitors in a single cortical area develops into diverse subtypes each projecting to particular brain areas and receiving specific brain-wide inputs. We are examining how genetic programs and neuronal activity interact to construct connectivity. We address these fundamental questions using novel neural circuit tracing systems with next-generation trans-synaptic viral tracers, mouse genetics, single-cell genome-wide sequencing, and in vivo imaging. My lab will address long-standing but previously unapproachable questions about how specific long-distance neural circuits are developed and organized at the single cell level, which will ultimately provide insights into neurodevelopmental disorders such as autism and schizophrenia.

近期论文

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In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nuñez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. Nature. 2016 Dec 1;540(7631):144-149. doi: 10.1038/nature20565. Epub 2016 Nov 16. Improved Monosynaptic Neural Circuit Tracing Using Engineered Rabies Virus Glycoproteins. Kim EJ, Jacobs MW, Ito-Cole T, Callaway EM. Cell Rep. 2016 Apr 26;15(4):692-699. doi: 10.1016/j.celrep.2016.03.067. Epub 2016 Apr 14. Three Types of Cortical Layer 5 Neurons That Differ in Brain-wide Connectivity and Function. Kim EJ, Juavinett AL, Kyubwa EM, Jacobs MW, Callaway EM. Neuron. 2015 Dec 16;88(6):1253-1267. doi: 10.1016/j.neuron.2015.11.002. Epub 2015 Dec 6. Gate control of mechanical itch by a subpopulation of spinal cord interneurons. Bourane S, Duan B, Koch SC, Dalet A, Britz O, Garcia-Campmany L, Kim E, Cheng L, Ghosh A, Ma Q, Goulding M. Science. 2015 Oct 30;350(6260):550-4. doi: 10.1126/science.aac8653. Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes. Alcantara Llaguno SR, Wang Z, Sun D, Chen J, Xu J, Kim E, Hatanpaa KJ, Raisanen JM, Burns DK, Johnson JE, Parada LF. Cancer Cell. 2015 Oct 12;28(4):429-440. doi: 10.1016/j.ccell.2015.09.007. Ascl1 controls the number and distribution of astrocytes and oligodendrocytes in the gray matter and white matter of the spinal cord. Vue TY, Kim EJ, Parras CM, Guillemot F, Johnson JE. Development. 2014 Oct;141(19):3721-31. doi: 10.1242/dev.105270. Epub 2014 Sep 5. Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL. Development. 2011 Oct;138(19):4131-42. doi: 10.1242/dev.065870. Epub 2011 Aug 18. Ascl1 genetics reveals insights into cerebellum local circuit assembly. Sudarov A, Turnbull RK, Kim EJ, Lebel-Potter M, Guillemot F, Joyner AL. J Neurosci. 2011 Jul 27;31(30):11055-69. doi: 10.1523/JNEUROSCI.0479-11.2011.