Ares, Manuel - University of California, Santa Cruz - Molecular, Cell & Developmental Biology Faculty

个人简介

B. S., Cornell University Ph.D., University of California, San Diego Postdoctorate, Yale University School of Medicin

研究领域

Intron Removal, Alternative Splicing, and Genomics Our work centers on the mechanisms and regulation of splicing. Splicing is required to remove intron sequences from pre-mRNA and create coding sequences for translation. We try to understand: (1) the mechanism of action of the core components of the spliceosome, in particular the snRNAs and their rearrangements during assembly of the spliceosome and catalysis of the splicing reactions, (2) the regulation of alternative splicing at a mechanistic level including the coupling of splicing to transcription and RNA decay mechanisms, and (3) the coordinate regulation of splicing events in developing systems.

近期论文

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Hypoxia Is Not a Main Stress When Mycobacterium tuberculosis Is in a Dormancy-Like Long-Chain Fatty Acid Environment. Del Portillo P, García-Morales L, Menéndez MC, Anzola JM, Rodríguez JG, Helguera-Repetto AC, Ares MA, Prados-Rosales R, Gonzalez-Y-Merchand JA, García MJ. Front Cell Infect Microbiol. 2019 Jan 9;8:449. doi: 10.3389/fcimb.2018.00449. eCollection 2018. Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay. Lucas BA, Lavi E, Shiue L, Cho H, Katzman S, Miyoshi K, Siomi MC, Carmel L, Ares M Jr, Maquat LE. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):968-973. doi: 10.1073/pnas.1715531115. Epub 2018 Jan 16. Autogenous cross-regulation of Quaking mRNA processing and translation balances Quaking functions in splicing and translation. Fagg WS, Liu N, Fair JH, Shiue L, Katzman S, Donohue JP, Ares M Jr. Genes Dev. 2017 Sep 15;31(18):1894-1909. doi: 10.1101/gad.302059.117. Epub 2017 Oct 11. RNA-binding protein CPEB1 remodels host and viral RNA landscapes. Batra R, Stark TJ, Clark E, Belzile JP, Wheeler EC, Yee BA, Huang H, Gelboin-Burkhart C, Huelga SC, Aigner S, Roberts BT, Bos TJ, Sathe S, Donohue JP, Rigo F, Ares M Jr, Spector DH, Yeo GW. Nat Struct Mol Biol. 2016 Dec;23(12):1101-1110. doi: 10.1038/nsmb.3310. Epub 2016 Oct 24. Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. Martinez FJ, Pratt GA, Van Nostrand EL, Batra R, Huelga SC, Kapeli K, Freese P, Chun SJ, Ling K, Gelboin-Burkhart C, Fijany L, Wang HC, Nussbacher JK, Broski SM, Kim HJ, Lardelli R, Sundararaman B, Donohue JP, Javaherian A, Lykke-Andersen J, Finkbeiner S, Bennett CF, Ares M Jr, Burge CB, Taylor JP, Rigo F, Yeo GW. Neuron. 2016 Nov 23;92(4):780-795. doi: 10.1016/j.neuron.2016.09.050. Epub 2016 Oct 20. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. Kapeli K, Pratt GA, Vu AQ, Hutt KR, Martinez FJ, Sundararaman B, Batra R, Freese P, Lambert NJ, Huelga SC, Chun SJ, Liang TY, Chang J, Donohue JP, Shiue L, Zhang J, Zhu H, Cambi F, Kasarskis E, Hoon S, Ares M Jr, Burge CB, Ravits J, Rigo F, Yeo GW. Nat Commun. 2016 Jul 5;7:12143. doi: 10.1038/ncomms12143. SMITten by the Speed of Splicing. Johnson TL, Ares M Jr. Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression. de Bruin RG, Shiue L, Prins J, de Boer HC, Singh A, Fagg WS, van Gils JM, Duijs JM, Katzman S, Kraaijeveld AO, Böhringer S, Leung WY, Kielbasa SM, Donahue JP, van der Zande PH, Sijbom R, van Alem CM, Bot I, van Kooten C, Jukema JW, Van Esch H, Rabelink TJ, Kazan H, Biessen EA, Ares M Jr, van Zonneveld AJ, van der Veer EP. Nat Commun. 2016 Mar 31;7:10846. doi: 10.1038/ncomms10846.