Ge, Xin - University of California, Riverside - Department of Chemical and Environmental Engineering

个人简介

Xin Ge received his Ph.D. (2008) from McMaster University, Canada; M.S. (2003) and B.S. (2000) from Tsinghua University, China, all in Chemical Engineering. He was a post-doctoral fellow (2008-2010) then a research associate (2010-2011) at University of Texas at Austin. Research interests include: inhibitory and neutralizing antibody discovery, therapeutic enzymes engineering, biocatalysis, directed evolution, quorum quenching, next generation sequencing and bioinformatics, high-throughput screening and selection.

研究领域

Biotechnology and Biomolecular EngineeringTherapeutic Antibody Discovery and Engineering

近期论文

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Lopez T, Ramirez A, Benitez C, Mustafa Z, Pham H, Sanchez R, Ge X. Selectivity Conversion of Protease Inhibitory Antibodies. Antibody Therapeutics. Accepted. Lopez T, Chen C, Ramirez A, Chen KE, Lorenson MY, Benitez C, Mustafa Z, Pham H, Sanchez R, Walker AM, Ge X. Epitope Specific Affinity Maturation Improved Stability of Potent Protease Inhibitory Antibodies. Biotechnology and Bioengineering, 2018 Aug 13. doi: 10.1002/bit.26814. [Epub ahead of print]. Nam DH, Ge X. Generation of Highly Selective MMP Antibody Inhibitors. In Proteases and Cancer. Methods in Molecular Biology (Clifton, N.J.) 1731:307-324 Jan 2018. Chen KE, Chen C, Radecki KC, Bustamante K, Lopez T, Lorenson MY, Ge X, Walker AM. Use of a Novel Camelid-inspired Human Antibody Demonstrates the Importance of MMP-14 to Cancer Stem Cell Function in the Metastatic Process. Oncotarget (2018) 9[50]:29431-29444. Lee KB, Nam DH, Nuhn JA, Wang J, Schneider IC, Ge X. Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli. Microbial Cell Factories (2017) 16[1]:73. Lopez T, Nam DH, Kaihara E, Mustafa Z, Ge X. Identification of Highly Selective MMP-14 Inhibitory Fabs by Deep Sequencing. Biotechnology and Bioengineering, (2017) 114[6]:1140-1150. Nam DH, Fang K, Rodriguez C, Lopez T, Ge X. Generation of inhibitory monoclonal antibodies targeting membrane-type 1 matrix metalloproteinase by motif grafting and CDR optimization. Protein Engineering Design and Selection (2017) 30[2]:113-118. Nam DH, Rodriguez C, Remacle AG, Strongin AY, Ge X. Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries. Proc Natl Acad Sci USA (2016), 113[52]:14970-14975. Li XC, Wang C, Mulchandani A, Ge X. Engineering Soluble Human Paraoxonase 2 for Quorum Quenching. ACS Chemical Biology (2016) 11[11]: 3122-3131. Nam DH, Ge X. Direct Production of Functional Matrix Metalloproteinase -14 Without Refolding or Activation and its Application for In Vitro Inhibition Assays. Biotechnology and Bioengineering (2016) 113[4]: 717-723. Nam DH, Ge X. Development of Periplasmic FRET-Based Screening Method for Protease Inhibitory Antibodies. Bioengineering and Biotechnology. (2013) 110[11]: 2856-2864.