Spindler, Stephen R - University of California, Riverside

个人简介

Ph.D., University of Texas at Houston, 1976 PHS Pre-doctoral Trainee NIH Postdoctoral Fellow

研究领域

Molecular Biology Biomedical Research

近期论文

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Dhahbi, J.M., Mote, P.L. and Spindler, S.R. Identification of potential calorie restriction mimetics by microarray profiling. Cell Aging, Submitted. Spindler, S.R. Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction. Mechanisms of Aging and Development. 31 May 2005. Epub ahead of print (2005). Dhahbi, J.M., Tsuchiya, T., Kim, H.J., Mote, P.L. and Spindler, S.R. Myocardial Genomic and Phenotypic Responses to Short- and Long-term Changes in Caloric Intake. Journal of Gerontology, Biological Sciences. In Press (2005). Tsuchiya, T., Dhahbi, J.M., Cui, X., Mote, P.L., Bartke, A. and Spindler, S.R. Additive regulation of hepatic gene expression by dwarfism and caloric restriction . Physiological Genomics, 19, 307-315 (2004); Epub 2004 Mar 23. Dhahbi, J.M., Kim, H.J., Mote, P.L. and Spindler, S.R. Temporal linkage between the physiologic and genomic responses to caloric restriction. Proc. Natl. Acad. Sci. USA. 101, 5524-5529 (2004); Epub 2004 Mar 25. Dhahbi, J.M. and Spindler, S.R. Aging of the liver. In, Biology of Aging and its Modulation, Vol. 3: Aging of Organs and Systems , Aspinall, R., ed., Kluwer Academic Publisher, Dordrecht , The Netherlands , pp. 271-291 (2003). Dhahbi, J.M., Mote, P.L., Cao, S.X., and Spindler, S.R. Hepatic Gene Expression Profiling of Streptozotocin-Induced Diabetes. Diabetes Technology & Therapeutics, 5, 411-420 (2003). Spindler, S.R. and Dhahbi, J.M. Protein Turnover, Energy Metabolism, Aging and Caloric Restriction. In, Energy Metabolism and Lifespan Determination: Advances in Cell Aging and Gerontology Vol. 14, Mattson, M.P., ed., Elsevier, Amsterdam , The Netherlands , pp. 69-86 (2003). Dhahbi, J.M., Cao, S.X., Mote, P.L., Wingo, J., Rowley, B.C., and Spindler, S.R. Postprandial induction of chaperone gene expression is rapid in mice. J. Nutr., 132, 31-37 (2002). Dhahbi, J.M., Mote, P.L., Wingo, J., Rowley, B.C., Cao, S.X., Walford, R.L., and Spindler, S.R. Caloric restriction alters the feeding response of key metabolic enzyme genes. Mech. Ageing Dev., 122, 35-50 (2001). Dhahbi, J.M., Cao, S.X., Tillman, J.B., Mote, P.L., Madore, M.A., Walford, R.L., and Spindler, S.R. Chaperone-mediated regulation of hepatic protein secretion by caloric restriction. Biochem. Biophys. Res. Commun. 284, 335-339 (2001). Spindler, S.R. Caloric restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging. Healthy Aging for Functional Longevity: Molecular and Cellular Interactions in Senescence, Park, S.C., Hwang, E.S., Kim, H.S., and Park, W.Y., eds. In, Annals of the New York Academy of Sciences 928, pp. 296-304 (2001). Weindruch, R., Keenan, K.P., Carney, J.M., Fernandes, G., Feuers, R.J., Floyd, R.A., Halter, J.B., Ramsey, J.J., Richardson, A., Roth, G.S., Spindler, S.R. Caloric restriction mimetics: Metabolic interventions. J. Gerontol. Biol. Sci. 56, 20-33 (2001).