Norman, Anthony W - University of California, Riverside

个人简介

B.A., Oberlin College, 1959 Ph.D., Biochemistry, University of Wisconsin, Madison, 1963 Postdoctoral, UCLA, Ernst Oppenheimer Award, 1963-64 The Endocrine Society, 1977

研究领域

Molecular Endocrinology Signal Transduction Biomedical Research

近期论文

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Norman, A.W., Mizwicki, M.T., Norman, D.P.G. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nature Reviews: Drug Discovery 3:27-41 (2004). (AWN-748.pdf) Zanello, L.P., and Norman, A.W. Rapid modulation of osteoblast ion channel responses by 1a,25(OH)2-vitamin D3PNAS 101: 1589-1594 (2004). (AWN-751.pdf) requires the presence of a functional vitamin D nuclear receptor. Mizwicki, M.T., Keidel, D., Bula, C.M.,Bishop, J. E.,Zanello, L.P., Wurtz, J.-M., Moras, D. and Norman, A.W. Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1a,25(OH)2-vitamin D3 signaling. PNAS 101:12876-12881 (2004). (AWN-759.pdf) Huhtakangas, J.A., Olivera, C.J., Bishop, J.E., Zanello, L.P, and Norman, A.W. The vitamin D receptor is present in caveolae and binds 1a,25(OH)2-vitamin D3 in vivo and in vitro. Mol. Endo. 18:2660-2671 (2004). (AWN-761.pdf) Bula, C.M., Huhtakangas, J.A., Olivera, C. J., Bishop, J.E., Norman, A.W., Henry, H.L. Presence of a Truncated Form of VDR in a Strain of VDR KO Mice. Endocrinology. 146:5581-5586 (2005). (AWN-769.pdf) Norman, A.W. Vitamin D Receptor (VDR): New assignments for an already busy receptor. Endocrinology 147: 5542-5548 (2006). (AWN-771.pdf) Vieth, R., Bischoff-Ferrari, H., Boucher, B., Dawson-Hughes, B., Garland, C., Heaney, R., Holick, M., Hollis, B., Lamberg-Allardt, C., McGrath, J., Norman, A., Scragg, R., Whiting, S., Willett, W., and Zittermann, A. The urgent need to recommend an intake of vitamin D that is effective. Am. J. Clin. Nutr. 2007 85: 649-650 (2007). (AWN-774.pdf) Bula, C., Bishop, J., Norman A.W. Conservative mutageneic perturbations of amino acids connecting helix 12 in the 1a,25(OH)2-D3 receptor (VDR) to the ligand cause significant transactivational effects. Journal of Steroid Biochemistry & Molecular Biology. 103: 286-292 (2007). (AWN-776.pdf) Menegaz, D., Barrientos-Duran, A., Kline, A., Silva, F.R., Norman, A.W. Mizwicki, M.T. and Zanello, L.P. 1,25(OH)2-VitaminD3 stimulation of secretion via chloride channel activation in Sertoli cells. J. Steroid Biochem. Mol. Biol. 119:127-134 (2010). AWN-793 Mizwicki, M.T., Menegaz, D., Yahgmaei, S., Henry, H.L. and Norman, A.W. A molecular description of ligand binding to the two overlapping binding pockets of the nuclear vitamin D receptor (VDR): Structure-function implications. J. Steroid Biochem. Mol. Biol. 121:98-105 (2010). AWN-794 Norman, A.W. and Bouillon, R. Vitamin D nutritional policy needs a vision for the future. Exp. Biol. Med. 235:1034-1045 (2010). AWN-795