Cheloufi, Sihem - University of California, Riverside

个人简介

Dr. Cheloufi obtained her B.Sc. degree in Molecular Genetics from King’s College University of London. She then moved to Cold Spring Harbor Laboratory where she joined Dr. Gregory Hannon’s group for her thesis project. Her doctorate work focused on investigating the role of small non-coding RNAs during mammalian development. She was awarded her Ph.D. in Genetics in 2010. Following her graduation, she joined the laboratory of Dr. Konrad Hochedlinger where she worked on identifying the key regulators of chromatin plasticity during cellular reprogramming. In 2017, she joined the department of Biochemistry at the UC Riverside as assistant professor.

研究领域

Stem Cells Cancer and Regenerative medicine Chromatin structure and regulatory RNAs

近期论文

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Li Y, Basavappa M, Lu J, Dong S, Cronkite DA, Prior JT, Reinecker HC, Hertzog P, Han Y, Li WX, Cheloufi S, Karginov FV, Ding SW, Jeffrey KL. (2016) Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells. Nature Microbiology. 2:16250. PMCID: PMC5488270 Borkent M, Bennett BD, Lackford B, Bar-Nur O, Brumbaugh J, Wang L, Du Y, Fargo DC, Apostolou E, Cheloufi S, Maherali N, Elledge SJ, Hu G and Hochedlinger K. (2016). A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2. Stem Cell Reports, 6, 1-13. PMCID: PMC4939549 Cheloufi S, Elling U, Hopfgartner B, Jung Y, Murn J, Maria Ninova Badeaux A, Ang CE, Tennen D, Ferrari F, Wesche D, Abazova N, Hogue M, Tasdemir N, Rathert P, Vidal S, Fellner M, Wenzel D, Zinner M, Stadtfeld M, Almouzni G, Lowe SW, Rinn J, Wernig M, Aravin A, Shi Y, Park P, Penninger JM, Zuber J, Hochedlinger K (2015) The histone chaperone CAF-1 safeguards somatic cell identity. Nature 528, 218–224. PMCID: PMC4866648 Murn J, Zarnack K, Yang YJ, Durak O, Murphy EA, Cheloufi S, Gonzalez DM, Teplova M, Curk T, Zuber J, et al. (2015). Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Genes and Development 29, 501-512. PMCID: PMC4358403 Apostolou E, Ferrari F, Walsh RM, Bar-Nur O, Stadtfeld M, Cheloufi S, Stuart HT, Polo JM, Ohsumi TK, Borowsky ML, et al. (2013). Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. Cell Stem Cell 12, 699-712. PMCID: PMC3725985 Polo JM, Anderssen E, Walsh RM, Schwarz BA, Nefzger CM, Lim SM, Borkent M, Apostolou E, Alaei, S, Cloutier J, Bar-Nur O, Cheloufi S, Stadtfeld M, Figueroa ME, Robinton D, Natesan S, Melnick A, Zhu J, Ramaswamy S, Hochedlinger K (2012). A molecular roadmap of reprogramming somatic cells into iPS cells. Cell 151, 1617-1632. PMCID: PMC3608203 Van Stry M, Oguin TH 3rd, Cheloufi S, Vogel P, Watanabe M, Pillai MR, Dash P, Thomas PG, Hannon GJ, Bix M (2012). Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection. Journal of Virology 86, 4151-4157. PMCID: PMC3318639 Cheloufi S, Dos Santos CO, Chong MM, Hannon GJ (2010). A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 465, 584-589. PMCID: PMC2995450 Cifuentes D, Xue H, Taylor DW, Patnode H, Mishima Y, Cheloufi S, Ma E, Mane S, Hannon GJ, Lawson ND, et al. (2010). A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science 328, 1694-1698. PMCID: PMC3093307 Chong MM, Zhang G, Cheloufi S, Neubert TA, Hannon GJ, Littman DR (2010). Canonical and alternate functions of the microRNA biogenesis machinery. Genes and Development 24, 1951-1960. PMCID: PMC2932976 Karginov FV, Cheloufi S, Chong MM, Stark A, Smith AD, Hannon GJ (2010). Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases. Molecular Cell 38, 781-788. PMCID: PMC2914474