个人简介

Dr. Blaha obtained his Ph.D. from the Vienna University of Technology, Vienna, Austria in 2001. His doctoral work focused on investigation of the translational apparatus using structural and functional approaches. In his post-doctoral research, Dr. Blaha continued his structural research on protein translation under the guidance of Nobel Laureate Thomas Steitz. In 2012, he joined the Department of Biochemistry at UC Riverside as Assistant Professor. Since then, his research has focused on the interplay between protein translation and transcription.

研究领域

In prokaryotes, transcription and translation are coupled. In vivo, decoupling transcription from translation leads to stalling of transcription on a genome-wide scale. This stalling causes DNA double strand breaks and therefore genome instability. Recent advances indicate that the interplay between RNA polymerase and the ribosome is at the core of this coupling. The basis of this interplay remains elusive. We are currently investigating the direct interactions between RNA polymerase and ribosomes, identifying both the interface between them and the thermodynamic and kinetic parameters for their interactions.

Physical Biochemistry Biophysics Crystallography

近期论文

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Fan H, Hahm J, Diggs S, Perry JJ, Blaha G. (2015) Structural and functional analysis of BipA, a regulator of virulence in enteropathogenic Escherichia coli. JBC 290, 20856-64. Stanley RE, Blaha G, Grodzicki RL, Strickler MD, Steitz TA. (2010) The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome. NSMB 17, 289-293. Blaha G, Stanley RE, Steitz TA. (2009) Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome. Science 325, 966-970. Blaha G, Gürel G, Schroeder SJ, Moore PB, Steitz TA. (2008) Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J. Mol. Biol. 379, 505-519. Evans RN, Blaha G, Bailey S, Steitz TA. (2008) The structure of LepA, the ribosomal back translocase. Proc Natl Acad Sci U S A. 105, 4673-8. Wendrich TM, Blaha G, Wilson DN, Marahiel MA, Nierhaus KH. (2002) Dissection of the mechanism for the stringent factor RelA. Mol Cell 10, 779-88.