个人简介

Michigan State University, 1993, BSc University of Illinois at Chicago, 1995, MSc University of Manchester Institute of Science and Technology, 1998, PhD Department of Chemistry, UBC, 1998, PostDdoctoral Fellow

研究领域

Fundamental and applied carbohydrate enzymology The focus of our Carbohydrate Enzymology Research Group is to understand the way in which particular enzymes act to alter the structure of polysaccharides found in biomass (especially plant cell walls and wood fibers), and to harness these enzymes for applications. We are primarily interested in the carbohydrate-active enzymes (CAZymes) which synthesize, re-arrange, and degrade glycosidic bonds. Studies of carbohydrate oxidases involved in polysaccharide functionalisation comprise another primary research area. In the biological context, we aim to elucidate the molecular details of polysaccharide synthesis and deconstruction in: biogenesis of plant cell walls recycling of biomass in the global carbon cycle breakdown of dietary fibre (non-starch polysaccharides) by the human gut microbiota [An excellent popular science overview of our research in this area, including an animated video and an audio interview with Prof. Brumer, has been produced by UBC SCIE300 students – click here to check it out.] The discovery and characterisation of new enzymes involved in these processes provides a foundation for the development of enzyme technology for the improved use of renewable biomass resources in the forest products, agricultural, and textile industries. Please see Prof Brumer’s homepage at the Michael Smith Laboratories line: http://www.msl.ubc.ca/faculty/brumer for more information on his group’s research.

Research in my group is focused on structure-function studies and applications of carbohydrate-active enzymes.

近期论文

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Fenger, T. Hauch; Brumer, H. Synthesis And Analysis Of Specific Covalent Inhibitors Of Endo-Xyloglucanases. CHEMBIOCHEM 2015, 16, 575-583.BibTex 2014 Oksanen, A. ; Retulainen, E. ; Brumer, H. Bulky Paper With Good Strength And Smoothness? Certainly!. NORDIC PULP & PAPER RESEARCH JOURNAL 2014, 29, 725-731.BibTex Martens, E. C. ; Kelly, A. G. ; Tauzin, A. S. ; Brumer, H. The Devil Lies In The Details: How Variations In Polysaccharide Fine-Structure Impact The Physiology And Evolution Of Gut Microbes. JOURNAL OF MOLECULAR BIOLOGY 2014, 426, 3851-3865.BibTex Brumer, H. ; Gilbert, H. J. Editorial Overview: Carbohydrate-Protein Interactions: The Future Is Taking Shape. CURRENT OPINION IN STRUCTURAL BIOLOGY 2014, 28, V-VII.BibTex Larsbrink, J. ; Thompson, A. J. ; Lundqvist, M. ; Gardner, J. G. ; Davies, G. J. ; Brumer, H. A Complex Gene Locus Enables Xyloglucan Utilization In The Model Saprophyte Cellvibrio Japonicus. MOLECULAR MICROBIOLOGY 2014, 94, 418-433.BibTex Anasontzis, G. E. ; Pena, M. Salazar; Spadiut, O. ; Brumer, H. ; Olsson, L. Effects Of Temperature And Glycerol And Methanol-Feeding Profiles On The Production Of Recombinant Galactose Oxidase In Pichia Pastoris. BIOTECHNOLOGY PROGRESS 2014, 30, 728-735.BibTex Song, Y. ; Gyarmati, P. ; Araujo, A. Catarina; Lundeberg, J. ; , ; Stahl, P. L. Visual Detection Of Dna On Paper Chips. ANALYTICAL CHEMISTRY 2014, 86, 1575-1582.BibTex Leppanen, A. - S. ; Xu, C. ; Parikka, K. ; Eklund, P. ; Sjoholm, R. ; Brumer, H. ; Tenkanen, M. ; Willfor, S. Targeted Allylation And Propargylation Of Galactose-Containing Polysaccharides In Water. CARBOHYDRATE POLYMERS 2014, 100, 46-54.BibTex Wang, Y. ; Vilaplana, F. ; Brumer, H. ; Aspeborg, H. Enzymatic Characterization Of A Glycoside Hydrolase Family 5 Subfamily 7 (Gh5\_7) Mannanase From Arabidopsis Thaliana. Planta 2014, 239, 653–665.BibTex Banasiak, A. ; Ibatullin, F. M. ; Brumer, H. ; Mellerowicz, E. J. Glycoside Hydrolase Activities In Cell Walls Of Sclerenchyma Cells In The Inflorescence Stems Of Arabidopsis Thaliana Visualized In Situ. Plants 2014, 3, 513–525.BibTex Song, Y. ; Gyarmati, P. ; Araujo, A. Catarina; Lundeberg, J. ; Brumer, H. ; Staahl, P. L. Visual Detection Of Dna On Paper Chips. Analytical chemistry 2014, 86, 1575–1582.BibTex Larsbrink, J. ; Rogers, T. E. ; Hemsworth, G. R. ; McKee, L. S. ; Tauzin, A. S. ; Spadiut, O. ; Klinter, S. ; Pudlo, N. A. ; Urs, K. ; Koropatkin, N. M. ; A. Creagh, L. ; Haynes, C. A. ; Kelly, A. G. ; Cederholm, S. Nilsson; Davies, G. J. ; Martens, E. C. ; Brumer, H. A Discrete Genetic Locus Confers Xyloglucan Metabolism In Select Human Gut Bacteroidetes. Nature 2014, 506, 498–502.BibTex 2013 Araujo, A. Catarina; Song, Y. ; Lundeberg, J. ; Stahl, P. L. ; Brumer, H. Activated Paper Surfaces For The Rapid Hybridization Of Dna Through Capillary Transport (Vol 84, Pg 3311, 2012). ANALYTICAL CHEMISTRY 2013, 85, 11676.BibTex Eklof, J. M. ; Shojania, S. ; Okon, M. ; McIntosh, L. P. ; Brumer, H. Structure-Function Analysis Of A Broad Specificity Populus Trichocarpa Endo-Beta-Glucanase Reveals An Evolutionary Link Between Bacterial Licheninases And Plant Xth Gene Products. Journal of Biological Chemistry 2013, 288, 15786-15799.BibTex Thongpoo, P. ; McKee, L. S. ; Araujo, A. Catarina; Kongsaeree, P. T. ; Brumer, H. Identification Of The Acid/base Catalyst Of A Glycoside Hydrolase Family 3 (Gh3) Beta-Glucosidase From Aspergillus Niger Asku28. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 2013, 1830, 2739-2749.BibTex Stepper, J. ; Dabin, J. ; Eklof, J. M. ; Thongpoo, P. ; Kongsaeree, P. ; Taylor, E. J. ; Turkenburg, J. P. ; Brumer, H. ; Davies, G. J. Structure And Activity Of The Streptococcus Pyogenes Family Gh1 6-Phospho-Beta-Glucosidase Spy1599. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 2013, 69, 16-23.BibTex Kaewthai, N. ; Gendre, D. ; Eklof, J. M. ; Ibatullin, F. M. ; Ezcurra, I. ; Bhalerao, R. P. ; Brumer, H. Group Iii-A Xth Genes Of Arabidopsis Encode Predominant Xyloglucan Endohydrolases That Are Dispensable For Normal Growth. PLANT PHYSIOLOGY 2013, 161, 440-454.BibTex 2012 Aspeborg, H. ; Coutinho, P. M. ; Wang, Y. ; Brumer, H. ; Henrissat, B. Evolution, Substrate Specificity And Subfamily Classification Of Glycoside Hydrolase Family 5 (Gh5). BMC EVOLUTIONARY BIOLOGY 2012, 12, 186.BibTex Parikka, K. ; Leppanen, A. - S. ; Xu, C. ; Pitkanen, L. ; Eronen, P. ; Osterberg, M. ; Brumer, H. ; Willfor, S. ; Tenkanen, M. Functional And Anionic Cellulose-Interacting Polymers By Selective Chemo-Enzymatic Carboxylation Of Galactose-Containing Polysaccharides. BIOMACROMOLECULES 2012, 13, 2418-2428.BibTex Araujo, A. Catarina; Nakhai, A. ; Ruda, M. ; Slattegard, R. ; Gatenholm, P. ; Brumer, H. A General Route To Xyloglucan-Peptide Conjugates For The Activation Of Cellulose Surfaces. CARBOHYDRATE RESEARCH 2012, 354, 116-120.BibTex Araujo, A. Catarina; Song, Y. ; Lundeberg, J. ; Stahl, P. L. ; Brumer, H. Activated Paper Surfaces For The Rapid Hybridization Of Dna Through Capillary Transport. Analytical Chemistry 2012, 84, 3311-3317.BibTex Bi, R. ; Spadiut, O. ; Lawoko, M. ; Brumer, H. ; Henriksson, G. Isolation And Identification Of Microorganisms From Soil Able To Live On Lignin As A Carbon Source And To Produce Enzymes Which Cleave The Beta-O-4 Bond In A Lignin Model Compound. CELLULOSE CHEMISTRY AND TECHNOLOGY 2012, 46, 227-242.BibTex Eklof, J. M. ; Ruda, M. C. ; Brumer, H. Distinguishing Xyloglucanase Activity In Endo-Beta(1 -> 4)Glucanases. In CELLULASES; Gilbert, H. J. ; CELLULASES; 2012; Vol. 510, pp. 97-120.BibTex Xu, C. ; Spadiut, O. ; Araujo, A. Catarina; Nakhai, A. ; Brumer, H. Chemo-Enzymatic Assembly Of Clickable Cellulose Surfaces Via Multivalent Polysaccharides. ChemSusChem 2012, 5, 661-665.BibTex Larsbrink, J. ; Izumi, A. ; Hemsworth, G. R. ; Davies, G. J. ; Brumer, H. Structural Enzymology Of Cellvibrio Japonicus Agd31B Protein Reveals Alpha-Transglucosylase Activity In Glycoside Hydrolase Family 31. JOURNAL OF BIOLOGICAL CHEMISTRY 2012, 287, 43288-43299.BibTex Silipo, A. ; Larsbrink, J. ; Marchetti, R. ; Lanzetta, R. ; Brumer, H. ; Molinaro, A. Nmr Spectroscopic Analysis Reveals Extensive Binding Interactions Of Complex Xyloglucan Oligosaccharides With The Cellvibrio Japonicus Glycoside Hydrolase Family 31 A-Xylosidase. CHEMISTRY-A EUROPEAN JOURNAL 2012, 18, 13395-13404.BibTex