Krummenacher, Claude F. - 中山大学

个人简介

Claude F. Krummenacher教授现任职于美国Rowan University科学与数学学院生物科学系和转化与医学系。Krummenacher教授于1995年获得瑞士洛桑大学理学博士学位。并于1996年前往美国费城Wistar研究所和宾夕法尼亚大学口腔医学院从事博士后研究。从2003年起至2014年分别在宾夕法尼亚大学口腔医学院微生物学系、生物化学系和病理学系担任研究助理、助理教授和高级研究员。2015年至今在美国罗文大学任职。　Krummenacher教授于2005年获得美国疱疹基金会的Stephen L Sacks研究者奖；于2007年获得宾夕法尼亚大学约瑟和约瑟芬拉比诺维茨奖杰出科学家奖；于2015年获得弗朗西丝罗文大学教师发展奖。

近期论文

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1. Bhargava, A.K., P.W. Rothlauf and C. Krummenacher. 2016. Herpes simplex virus glycoprotein D relocates nectin-1 from intercellular contacts. Virology, 499:267-277. 2. Lazear E., J.C. Whitbeck, Y. Zuo, A. Carfí, G.H. Cohen, R.J. Eisenberg and C. Krummenacher. 2014. Dynamics of conformational changes at the N-terminus of herpes simplex virus glycoprotein D induced by HVEM and nectin-1. Virology 448;185-95. 3. Di Giovine P., E.C. Settembre, A.K. Bhargava, M.A. Luftig, H. Lou, G.H. Cohen, R.J. Eisenberg, C. Krummenacher and A. Carfi. 2011. Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1. PLOS Pathogens. 7(9): e1002277. 4. Stiles K.M., J.C. Whitbeck, H. Lou, G.H. Cohen, R.J. Eisenberg and C. Krummenacher. 2010. Herpes simplex virus glycoprotein D interferes with HVEM binding to its ligands through down-regulation and direct competition. J. Virol. 84:11646-60. 5. Stiles K.M. and C. Krummenacher. 2010. Glycoprotein D actively induces rapid internalization of two nectin-1 isoforms during herpes simplex virus entry. Virology. 399:109-19 and cover. 6. Boesze-Battaglia K., A. Brown, L. Walker, D. Besack, A. Zekavat, S. Wrenn, C. Krummenacher and B.J. Shenker. 2009. Cytolethal distending toxin induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. J. Biol. Chem. 284:10650-8. 7. Stiles K.M., R.S.B. Milne, G.H. Cohen, R.J. Eisenberg and C. Krummenacher. 2008. The herpes simplex virus receptor nectin-1 is down-regulated after trans-interaction with glycoprotein D. Virology. 373:98-111. 8. Krummenacher C., V.M. Supekar, J.C. Whitbeck, E. Lazear, S.C. Connolly, R.J. Eisenberg, G.H. Cohen, D.C. Wiley and A. Carfi. 2005. Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry. EMBO J. 24:4144-53. 9. Krummenacher C., F. Baribaud, M. Ponce de Leon, I. Baribaud, J.C. Whitbeck, R. Xu, G.H. Cohen and R.J. Eisenberg. 2004. Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus. Virology.332: 286-99. 10. Krummenacher C., I. Baribaud, R.J. Eisenberg and G.H. Cohen. 2003. Cellular localization of nectin-1 and glycoprotein D during herpes simplex virus infection. J. Virol. 77:8985-99.