Zheng, Nan - University of Arkansas-Fayetteville

个人简介

EDUCATION University of Rochester, Rochester, NY M.S. 1995 University of Michigan, Ann Arbor, MI Ph.D. 2005 Massachusetts Institute of Technology Postdoc 2005-2008 HONORS 2005-2006 NIH NCI Postdoctoral Trainee 2006-2008 NIH Ruth L. Kirschstein NRSA Postdoctoral Fellow

研究领域

Research in our group is focused on the development of transition metal catalyzed methods and their application to the total synthesis of complex molecules with promising biological activities. Specifically, we are interested in developing new reactions that have the potential to open avenues for forming carbon-carbon bonds and carbon-nitrogen bonds. For example, functionalization of carbon-hydrogen bonds catalyzed by late transition metals could allow for untraditional bond disconnections in constructing molecules. Such processes could enable the direct conversion of a carbon-hydrogen bond to a carbon-metal bond, which could be further transformed to a carbon-carbon bond or carbon-nitrogen bond. Additionally, we are interested in harnessing the potential of nitrogen radicals to form carbon-nitrogen bonds. Despite their potential, the use of these species in the preparation of nitrogen-containing compounds has been limited. This is likely due to several factors, such as the limited number of available precursors, the requirement of Bu3SnH as a reagent, and the need for special conditions such as photolysis or strongly acidic conditions. Some natural products, such as those shown below, possess unique molecular architectures and interesting biological properties. As we develop new methods, we plan to pursue these targets and highlight our chemistry.

近期论文

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Tsang, W. C. P.; Munday, R.; Gordon, B.; Zheng, N.; Buchwald, S. L. “A Palladium-Catalyzed Method for the Synthesis of Carbazoles via Tandem C-H Functionalization and C-N Bond Formation” J. Org. Chem. 2008, 73, 7603-7610. Handa, M.; Scheidt, K.; Bossart, M.; Zheng, N.; Roush, W. R. “Studies on the Synthesis of Apoptolidin A. 1. Synthesis of the C(1)-C(11) Fragment” J. Org. Chem. 2008, 73, 1031-1035. Zheng, N.; Buchwald, S. L. “A Copper-Catalyzed Regiospecific Synthesis of N-Alkyl Benzimidazoles.” Org. Lett. 2007, 9, 4749-4751. Zheng, N.; Anderson, K. W.; Huang, X.; Nguyen, H. N.; Buchwald, S. L. “A Palladium-Catalyzed Regiospecific Synthesis of N-Aryl Benzimidazoles.” Angew. Chem., Int. Ed. 2007, 46, 7509-7512. Tsang, W. C. P.; Zheng, N.; Buchwald, S. L. “Combined C-H Functionalization/C-N Bond Formation Route to Carbazoles.” J. Am. Chem. Soc. 2005, 127, 14560-14561. Zheng, N.; Armstrong, J. D., III; Keller, J.; Liu, T.; Purick, J. L.; Bhupathy, M.; Volante, R. P. “A Convergent Asymmetric Synthesis of the Growth Hormone Secretagogue.” Tetrahedron: Asymmetry 2003, 14, 3435-3446. McWilliams, J. C.; Fleitz, F. J.; Zheng, N.; Armstrong, J. D., III “Preparation of N-Butyl 4-Chlorophenyl Sulfide.” Organic Syntheses 2002, 79, 43-51. Fleitz, F. J.; Lyle, T. A.; Zheng, N.; Armstrong, J. D., III; Volante, R. P. “Kilogram Scale Synthesis of the Pyrazinone Acetic Acid Core of an Orally Efficacious Thrombin Inhibitor.” Synth. Commun. 2000, 30, 3171-3180. Zheng, N.; McWilliams, J. C.; Fleitz, F. J.; Armstrong, J. D., III; Volante, R. P “Palladium-Catalyzed Synthesis of Aryl Sulfides from Aryl Triflates.” J. Org. Chem. 1998, 63, 9606-9607. Zheng, N.; Armstrong, J. D., III; McWilliams, J. C.; Fleitz, F. J.; Volante, R. P “Aymmetric Synthesis of α–Amino Acid Derivatives via an Electrophilic Amination of Chiral Amide Cuprates with Li-t-Butyl-N-Tosyloxycarbamate.” Tetrahedron Lett. 1997, 38, 2817-2820. McWilliams, J. C.; Armstrong, J. D., III; Zheng, N.; Bhupathy, M.; Volante, R. P.; Reider, P. “Tandem Asymmetric Transformations: an Asymmetric 1,2-Migration from a Higher Order Zincate Coupled with a Stereoselective Homoaldol Reaction.” J. Am. Chem. Soc. 1996, 118, 11970-11971.