Stenken, Julie - University of Arkansas-Fayetteville

个人简介

B.S. Chemistry, University of Akron, 1990 Ph.D. Bioanalytical Chemistry, University of Kansas, 1995 J. William Fulbright Fellow, The Karolinska Institute, Stockholm Sweden, 1994-1995 Postdoctoral Fellow, University of Kansas Medical School, Kansas City, KS, 1995-1996

研究领域

Our interdisciplinary research involves the areas of bioanalytical chemistry, bioengineering, biomaterials, and signal transduction and focuses on the development and improvement of analytical methods for in vivo measurements. A primary aim in the Stenken group is to understand the inflammatory response caused by macrophages to implanted foreign materials. Understanding the underlying biochemistry that occurs at the site of an implanted biomaterial is important in a wide range of clinical contexts — from reconstructive surgery to implantable glucose sensors. Many of the problems that have been encountered in the development of in vivo sensors have been due to the lack of understanding of the host response to implanted materials. To access the microenvironment of the foreign body response to a biomaterial, we use microdialysis sampling. A wide range of chromatographic, immunochemical, and spectroscopic analysis methods are used and developed by our research group for analyte detection in the low microliter volume dialysates. Current projects include collection and detection of the soluble messenger proteins (cytokines) during the inflammatory response; creation and mathematical modeling of microdialysis enhanced mass transport techniques; in situ detection of matrix metalloproteinases using imaging mass spectrometry; calibration of microdialysis sampling devices during protein collection; and creation of improved in vivo sampling devices.

近期论文

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S. Muruganantham, R. Liyanage, J.O. Lay Jr, and J.A. Stenken. Towards visualizing the spatial expression of matrix metalloproteinases (MMPs) activity during the foreign body response (FBR) using MALDI imaging MS. Poster presentation at the 59th ASMS Meeting, Denver, CO, June 2011. A.W. Herbaugh and J.A. Stenken. Antibody-Enhanced Microdialysis Collection of CCL2 from Rat Brain. Journal of Neuroscience Methods, 2011, E Pub May 11 X. Mou, M. R. Lennartz, D. J. Loegering, and J. A. Stenken. Modulation of the Foreign Body Reaction: Microdialysis Probes as Localized Drug Delivery/Sampling Device. Journal of Diabetes Science and Technology, 2011, 5: 619-631. J. Duo and J.A. Stenken. In vitro and in vivo affinity microdialysis sampling of cytokines using heparin-immobilized microspheres. Analytical and Bioanalytical Chemistry, 2011, 399, 783-793. E.C. von Grote, V. Venkatakrishnan, J. Duo, and J.A. Stenken. Long-term subcutaneous microdialysis sampling and qRT-PCR of MCP-1, IL-6 and IL-10 in freely-moving rats. Molecular BioSystems, 2011, 7: 150-161. X. Mou, M. Lennartz, D.J. Loegering, and J.A. Stenken. Long-term calibration considerations during subcutaneous microdialysis sampling in mobile rats. Biomaterials, 2010, 31: 4530-4539. D.D. Cunningham and J.A. Stenken (editors) "In Vivo Glucose Sensing," John Wiley & Sons, Hoboken, NJ. 2010. Y. Wang, D. Zagorevski, M.R. Lennartz, D.J. Loegering, J.A. Stenken. Detection of in vivo matrix metalloproteinase activity using microdialysis sampling and liquid chromatography-mass spectrometry. Analytical Chemistry, 2009, 81:9961-9971. X. Wang, D. J. Loegering, M.R. Lennartz and J. A. Stenken. Multiplexed cytokine detection of interstitial fluid collected from polymeric hollow tube implants. Cytokine, 2008, 43: 15-19. A. Gupta, H. Denver, A.H. Hirsa,J. Stenken,D.-A. Borca-Tasciuc. Localized, low-voltage electroosmotic pumping across nanoporous membranes. Applied Physics Letters, 2007, 91: 09410/1-09410/3. J.A. Stenken. Microdialysis Sampling, "Encyclopedia of Medical Devices and Instrumentation," 2nd Edition, Volume 4. John G. Webster (Editor). John Wiley & Sons, Inc. Hoboken, NJ. 2006 pp. 400-420. X. Ao and J. A. Stenken. Microdialysis sampling of cytokines. Methods, 2006, 38: 331-341. R. Chen, J.T. Warden, and J.A. Stenken, Microdialysis sampling coupled with ESR spin trapping for superoxide radical detection in microliter sample volumes. Analytical Chemistry, 2004, 76: 4734-4740. J.A. Stenken. Methods and issues in microdialysis calibration. Analytica Chimica Acta 1999, 379: 337-358.