Shi, Wei - University of Arkansas-Fayetteville

个人简介

2008-2012, Postdoctoral Fellow, Johns Hopkins School of Medicine, MD 2008, Ph.D., University of Alberta, Canada 2000, M. Sc., East China University of Science and Technology, China 1993, B.Sc., Shanghai Jiao Tong University, China

研究领域

Chemical Biology, Medicinal Chemistry, and Organic Synthesis Our long-term research objective is to increase the impact of organic chemistry (both molecules and reactions) on biomedical research. Effective crosstalk between chemistry and biology has made synthetic small molecules thrive in the field of chemical genetics; however, their counterpart of natural products generated from phenotypic screens is lagging far behind. To overcome many challenges in natural products research, especially target identification, we aim at using Medicinal Chemistry, Organic Synthesis, and Chemical Proteomics as tools to understand biological systems in the context of drug design and drug discovery.

近期论文

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Peng, C.-C.; Shi, W.; Lutz, J. D.; Kunze, K. L.; Liu, J. O.; Nelson, W. L.; Isoherranen, N.* “Stereospecific metabolism of itraconazole by CYP3A4: a new metabolic pathway of dioxolane ring scission for azole antifungals” Drug. Metab. Dispos. 2012, 40, 426–435. Shi, W.; Nacev, B. A.; Aftab, B.; Head, S.; Rudin, C. M.; Liu, J. O.* “Itraconazole side chain analogs: structure–activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and Hedgehog signaling” J. Med. Chem. 2011, 54, 7363–7374. Shi, W.; Lowary, T. L.* “Effect of carbohydrate amino group modifications on the cytotoxicity of glycosylated 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans” Bioorg. Med. Chem. Lett. 2011, 21, 2591–2596. Shi, W.; Lowary, T. L.* “Structure–activity relationships in glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans as DNA binding and potential anti-tumor agents” Bioorg. Med. Chem. 2011, 19, 1779–1789. Shi, W.; Marcus, S. L.; Lowary, T. L.* “Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans” Bioorg. Med. Chem. 2011, 19, 603–612. Shi, W.; Nacev, B. A.; Bhat, S.; Liu, J. O.* “Impact of absolute stereochemistry on the antiangiogenic and antifungal activities of itraconazole” ACS Med. Chem. Lett. 2010, 1, 155–159. Yang, G.; Tran, H.; Fan, E.; Shi, W.; Lowary, T. L.; Xu, Y.* “Determination of the absolute configurations of synthetic daunorubicin analogues using vibrational circular dichroism spectroscopy and density functional theory” Chirality, 2010, 22, 734–743. Shi, W.; Marcus, S. L.; Lowary, T. L.* “Synthesis and antibacterial activity of aminosugar-functionalized intercalating agents” Carbohydr. Res. 2010, 345, 10–22. Shi, W.; Coleman, R. S.; Lowary, T. L.* “Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics” Org. Biomol. Chem. 2009, 7, 3709–3722. Fan, E.; Shi, W.; Lowary, T. L.* “Synthesis of daunorubicin analogs containing truncated aromatic cores and unnatural monosaccharide residues” J. Org. Chem. 2007, 72, 2917–2928. Ridgway, K. M.; Shi, W.; Lin, S.-J.; Palcic, M. M.; Lowary, T. L.* “Chemical and chemoenzymatic synthesis of a trisaccharide fragment of Tsukamurella Paurometabola lipoarabinomannan” Can J. Chem. 2006, 84, 642–649. Luu, T.; Shi, W.; Lowary, T. L.*; Tykwinski, R. R.* “A divergent synthesis of triyne natural products and glycosylated analogues using a carbenoid rearrangement” Synthesis 2005, 3167–3178. Shi, W.; Qian, X.*; Zhang, R.; Song, G. “Synthesis and quantitative structure–activity relationships of new 2,5-disubstituted-1,3,4-oxadiazoles” J. Agric. Food Chem. 2001, 49, 124–130. Shi, W.; Qian, X.*; Song, G.; Zhang, R.; Li, R. “Syntheses and insecticidal activities of novel 2-fluorophenyl-5-aryl/cyclopropyl-1,3,4-oxadiazoles” J. Fluorine Chem. 2000, 106, 173–179.