Sakon, Joshua - University of Arkansas-Fayetteville

个人简介

Southern Oregon University, Ashland B.S. 1989 A.C.S. Ph.D. 1993, Biophysics, University of Wisconsin, Madison Postdoc 1993-1997, Biochemistry, Cornell University, Ithaca NY

研究领域

protein crystallography My NIH research at the University of Arkansas has resulted in some very interesting results showing that we can promote bone and skin growth and repair. To understand the mystery of biological processes in terms of chemistry and physics, three-dimensional structural information at near atomic resolution is desired. My lab uses the X-ray diffraction method to explore the events in medicinally important biochemistry at an atomic level. Our ultimate goal is to bring drugs/devices from bench to bedside. One of the drug candidates PTH-CBD is licensed to BiologicsMD. Other drug candidates are being helped by others.

近期论文

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Sikora B, Chen Y, Lichti CF, Harrison MK, Jennings TA, Tang Y, Tackett AJ, Jordan JB, Sakon J, Cameron CE, Raney KD. Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitro. J Biol Chem. 2008 Apr 25;283(17):11516-25. Epub 2008 Feb 18. Philominathan, ST, Matsushita O, Jordan JB, Sakon J. 1H, 13C and 15N resonance assignments of Ca2+ bound collagen-binding domain derived from a clostridial collagenase.Biomol NMR Assign. 2008 Dec;2(2):127-9. Epub 2008 Jul 22 Philominathan, ST. Koide, K. Hamada, H. Yasui, S. Seifert, O. Matsushita and J. Sakon, Unidirectional binding of clostridial collagenase to triple helical substrates. (2009) J. Biol Chem. 2009 Apr 17;284(16):10868-76. Epub 2009 Feb 10. Philominathan ST, Matsushita O, Gensure R, Sakon J. Ca2+-induced linker transformation leads to a compact and rigid collagen-binding domain of Clostridium histolyticum collagenase. FEBS J. 2009 Jul;276(13):3589-601. Epub 2009 May 28. Kim JW, Moon HM, Benamara M, Sakon J, Salamo GJ, Zharov VP. Aqueous-phase synthesis of monodisperse plasmonic gold nanocrystals using shortened single-walled carbon nanotubes. Chem Commun (Camb). 2010 Oct 14;46(38):7142-4. Epub 2010 Aug 25.