Kumar, T.K.S. - University of Arkansas-Fayetteville

个人简介

Ph.D. Osmania University, Hyderabad, India - 1993

研究领域

Protein Structure, Dynamics, Interaction and Folding Determination of three-dimensional solution structures of proteins using multidimensional NMR spectroscopy. Characterization of protein-protein interactions using a variety of biophysical techniques such as circular dichroism, fluorescence spectroscopy, Isothermal titration calorimetry, Infrared spectroscopy and NMR spectroscopy. Investigation of the backbone dynamics of proteins based on 15N-and 13C-relaxation measurements using NMR spectroscopy. Rational design of drugs by SAR by NMR and molecular modeling techniques. Characterization of protein-folding/unfolding pathways of beta-sheet proteins and membrane proteins. Development of new pulse sequences for multidimensional NMR spectroscopy. Understanding the specificity of protein aggregation. Characterization of amyloid-like fibrils and development of new experimental strategies to recover recombinant proteins from inclusion bodies

近期论文

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S. Jayanthi & T. K. S. Kumar. (2011) Cloning of WAP domain proteins. Book Chapter in Molecular Cloning (ISBN 978-953-307-398-9) Publisher – In Tech, New York, USA. N. Lewis, A.D. Kight, A.Daily, T. K. S. Kumar, R. L. Henry, and R. L. Goforth (2010) The C Terminus of Alb3 Interacts with the Chromodomains 2 and 3 of cpSRP43. J. Biol. Chem., 285 (53), 26-28. N. Lewis, N. J. Marty, K. M. Kathir, D. Rajalingam, A. D. Kight, A. E. Daily, T. K. S. Kumar, R.L. Henry, and R.L.Goforth. (2010) A Dynamic CpSRP43-Alb3 Interaction Mediates Translocase Regulation of cpSRP Target Components Interaction of cpSRP43 and the C-terminus of Albino3 Mediates Translocase Regulation of cpSRP. J. Biol. Chem., 285 (44), 34220-34230. Kathir, K. M., L. Gao., D. Rajalingam, A. Daily, H. Liu, D. Davis, P. Adams, I Prudovsky, T. K. S Kumar. (2010) Characterization of the Copper and Lipid Interactions of the C2B domain of Synaptotagmin 1 - Relavance to the Non-Classical Secretion of the Human Acidic Fibroblast Growth Factor. Invited Article Biochem. Biophys. Acta.- Biomembranes, 1798, 297-302. Aranganathan, S., T. K. S. Kumar, C. M. Huang, C.Yu and D.H. Chin. A superior drug carrier – aponeocarzinostatin in a partially unfolded state fully protects the labile enediyne (2009) J. Biomed. Sci., 16, 48-56. N. Marty, D. Rajalingam, A. Kight, Fologea, D., T. K. S. Kumar, R. Henry and R. L. Goforth. Membrane-activated structural switch mechanism in signal recognition particle receptor function. (2009) J. Biol. Chem. 284, 14891-14903 (Chosen as the paper of the week by the Editor of the Journal) Graziani, I., A. Doyle, S. Sterling, Kirov, A., F. Tarantini, M. Landriscina, T. K. S. Kumar, D. Neivandt, and I. Prudovsky (2009) Protein folding does not prevent the nonclassical export of FGF1and S100A13. Biochem. Biophys. Res. Commun., 381, 350-354. Rajalingam, D., C. Loftis, J. Xu and T. K. S. Kumar (2009) Trichloroacetic Acid-Induced Protein Precipitation Involves the Reversible Association of a Stable Partially Structured Intermediate. Protein. Sci. 18, 980-993. Kandasamy, J., P. Hariharan, T. K. S. Kumar, C. Yu, T.H. Lu and D. H. Chin. (2008) Is association of labile chromophore to aponeocarzinostatin a mutually assured protection for carrier protein. Analytical Biochem. 381, 18 – 26. Kathir, K.M., D. Rajalingam, V. Sivaraja, R. Goforth, C. Yu, R. Henry and T. K. S. Kumar. (2008) Assembly of chloroplast signal recognition particle involves structural rearrangement in cpSRP43. (2008) J. Mol. Biol., 381, 49 – 60. Ananthamurthy, K., K. M. Kathir, A. Kight, R. Goforth, R. Henry and T. K. S. Kumar (2008) 1H, 15N, and 13C resonance assignments of the C-terminal domain of the 43 kDa subunit of the chloroplast signal recognition particle. Biomolecular Resonance Assignments, 2, 37-39. Sharma, P., D. Rajalingam, T. K. S. Kumar and S. Singh. Light scattering studies of Fibroblast growth factor (FGF) interaction with ribonuclease (RNase) and D2 domain proteins (2008). Biophys. J., 94, 71-73. Rajalingam, D., K. M. Kathir, K. Ananthamurthy, P. D. Adams and T. K. S. Kumar. An efficient method to prevent degradation of recombinant proteins by Thrombin (2008). Anal. Biochem., 375, 361-363. Prudovsky, I., F. Tarantini, M. Landriscina, D. Neivandt, R. Soldi, A. Kirov, D. Rajalingam, T. K. S. Kumar. Secretion without Golgi. (2008) J. Cell. Biochem. 103, 1327-1343. K. M. Kathir, K. Ibrahim, D. Rajalingam, I. Prudovsky and T. K. S. Kumar. S100A13 lipid interactions – Role in the non-classical secretion of the acidic fibroblast growth factor. (2007) Biochim. Biophys. Acta., 1768, 3080. Ghule, A. K., K. M. Kathir, T. K. S. Kumar, C. Yu and Y. C. Ling) Carbon nanotubes prevent 2, 2, 2, -trifluoroethanol induced aggregation of protein (2007) Carbon, 45, 1586. Rajalingam, D., I. Graziani, I. Prudovsky, C. Yu. and T. K. S. Kumar. Acidic Fibroblast growth factor and the C2A domain of synaptotagmin exist as partially structured states under acidic conditions – Relevance in the non-classical secretion of the fibroblast growth factor. (2007) Biochemistry, 46, 9225. Rajalingam, D., D. Kacer, I. Prudovsky and T. K. S. Kumar. Molecular cloning, overexpression and characterization of interleukin 1a. (2007) Biochem. Biophys. Res. Commun. 360, 604. An, T., T. K. S. Kumar, M. Wang, L.Lu, J. Lay, R.Linayage, J. Berry, M. Gantar, V.Marks, R. E. Gawley and K. S. Rein. The Structures of Pahayokolides A and B: Two Cyclic Peptides from a Lyngbya sp. (2007) J. Nat. Prod., 70, 730. Graziani, I., C. Bagala, M. Duarta, R. Soldi, V. Kolev, F. Tarantini, T. K. S. Kumar, A. Doyle, D. Neivandt, C. Yu, T. Maciag and I. Prudovsky. Non-classical release of FGF-1 and p40 synaptotagmin 1 correlates with their membrane destabilizing properties. (2006) Biochem. Biophys. Res. Commun. 349, 192.