Koeppe, Roger - University of Arkansas-Fayetteville

个人简介

A.B., Haverford College, 1971; Ph.D., California Inst. of Technology, 1976; Awards NSF Predoctoral Fellow, 1971-74; NIH Postdoctoral Fellow, Stanford Univ., 1976-79; NIH Career Development Award, 1981-86; UA Alumni Research Award, 1992; Fulbright Fellow, Netherlands, 1992; Fulbright College Research Award, 2000;

研究领域

Membrane Active Peptides Protein Engineering and Protein/Lipid Interactions Our laboratory does research on membrane proteins, including voltage-dependent ion channels, lipid rafts, and designed, anchored transmembrane alpha- and beta-helical peptides. Further information about research projects, students and publications may be found on our research web page.

近期论文

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Martfeld, Ashley N., Venkatesan Rajagopalan, Denise V. Greathouse, and Roger E. Koeppe II (2015) BBA Biomembranes xx, in press. Dynamic regulation of lipid–protein interactions. (See this article) Sparks, Kelsey A., Nicholas J. Gleason, Renetra Gist, Rebekah Langston, Denise V. Greathouse and Roger E. Koeppe II (2014) Biochemistry 53, 3637-3645. Comparisons of Interfacial Phe, Tyr and Trp Residues as Determinants of Orientation and Dynamics for GWALP Transmembrane Peptides. (See this article) Gleason, Nicholas J., Vostrikov, Vitaly V., Greathouse, Denise V., and Koeppe, Roger E., II (2013) Proc. Natl. Acad. Sci., U. S. A. 110, 1692-1695. Buried lysine, but not arginine, titrates and alters transmembrane helix tilt. (See this article) Vorobyov, Igor, Timothy E. Olson, Jung H. Kim, Roger E. Koeppe II, Olaf S. Andersen, and Toby W. Allen (2014) Biophys. J. 106, 586-597. Ion-Induced Defect Permeation of Lipid Membranes. (See this article) Gleason, Nicholas J., Denise V. Greathouse, Christopher V. Grant, Stanley J. Opella, and Roger E. Koeppe II (2013) J. Phys. Chem. B 117, 13786-13794. Single Tryptophan and Tyrosine Comparisons in the N-terminal and C-terminal Interface Regions of Transmembrane GWALP Peptides. (See this article) Vostrikov, Vitaly V., Christopher V. Grant, Stanley J. Opella, and Roger E. Koeppe II (2011) Biophys. J. 101, 2939-2947. On the Combined Analysis of 2H and 15N/1H Solid-State NMR Data for Determination of Transmembrane Peptide Orientation and Dynamics. (See this article) Bruno, Michael J., Radda Rusinova, Nicholas J. Gleason, Roger E. Koeppe II and Olaf S. Andersen (2013) Faraday Discuss. 161, 461-480. Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. (See this article) Rankenberg, Johanna M., Vostrikov, V. V., Greathouse, D. V., Grant, C. V., Opella, S. J., and Koeppe, R. E., II. (2012) Biochemistry 51, 10066-10074. Properties of Membrane-Incorporated WALP Peptides that are Anchored on Only One End. (See this article) Vostrikov, Vitaly V., Benjamin A. Hall , Mark S. P. Sansom , and Roger E. Koeppe II (2012) J. Phys. Chem. B 116, 12980-12990. Accommodation of a Central Arginine in a Transmembrane Peptide by Changing the Placement of Anchor Residues. (See this article) Rankenberg, Johanna M., Vitaly V. Vostrikov, Christopher D. DuVall, Denise V. Greathouse, Roger E. Koeppe II, Christopher V. Grant, Stanley J. Opella (2012) Biochemistry 51, 3554-3564. Proline Kink Angle Distributions for GWALP23 in Lipid Bilayers of Different Thickness. (See this article) Gleason, Nicholas J., Vitaly V. Vostrikov, Denise V. Greathouse, Christopher V. Grant, Stanley J. Opella, and Roger E. Koeppe II (2012) Biochemistry 51, 2044-2053. Tyrosine Replacing Tryptophan as an Anchor in GWALP Peptides. (See this article) Ingólfsson, Helgi I., Roger E. Koeppe II and Olaf S. Andersen (2011) FEBS Lett. 585, 3101-3105. Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties. (See this article) Vostrikov, Vitaly V., and Roger E. Koeppe II (2011) Biochemistry 50, 7522-7535. Response of GWALP Transmembrane Peptides to Changes in the Tryptophan Anchor Positions. (See this article) Gu, Hong , Kevin Lum, Jung H. Kim, Denise V. Greathouse, Olaf S. Andersen and Roger E. Koeppe, II (2011) Biochemistry 50, 4855-4866. The Membrane Interface dictates Different Anchor Roles for “Inner Pair” and “Outer Pair” Tryptophan Indole Rings in Gramicidin A Channels. (See this article) Ingólfsson, Helgi I., Yuhui Li, Vitaly V. Vostrikov, Hong Gu, James F. Hinton, Roger E. Koeppe II, Benoît Roux and Olaf S. Andersen (2011) J. Phys. Chem. B, 115, 7417–7426. Gramicidin A Backbone and Side Chain Dynamics Evaluated by Molecular Dynamics Simulations and Nuclear Magnetic Resonance Experiments. I: Molecular Dynamics Simulations. (See this article) Vostrikov, Vitaly V., Hong Gu, Helgi I. Ingólfsson, James F. Hinton, Olaf S. Andersen, Benoît Roux and Roger E. Koeppe II (2011) J. Phys. Chem. B, 115, 7427–7432. Gramicidin A Backbone and Side Chain Dynamics Evaluated by Molecular Dynamics Simulations and Nuclear Magnetic Resonance Experiments. II: Nuclear Magnetic Resonance Experiments. (See this article) Lundbæk, Jens A.; Roger E. Koeppe II; and Olaf S. Andersen (2010) Proc. Natl. Acad. Sci. USA, 107, 15427-30. Amphiphile regulation of ion channel function by changes in the bilayer spring constant. (See this article) Daily, Anna E., Jung H. Kim, Denise V. Greathouse, Olaf S. Andersen, and Roger E. Koeppe II (2010) Biochemistry 49, 6856-6865. Polar groups in membrane channels: Consequences of replacing alanines with serines in membrane-spanning gramicidin channels. (See abstract) (See full text) Yu, Haibo, Christopher L. Mazzanti, Troy W. Whitfield, Roger E. Koeppe II, Olaf S. Andersen, and Benoît Roux (2010) J. Am. Chem. Soc. 132, 10847-10856. A combined experimental and theoretical study of ion solvation in liquid N-methylacetamide. (See this article) Vostrikov, Vitaly V.; Anna E. Daily; Denise V. Greathouse; and Roger E. Koeppe II (2010) J. Biol. Chem., 285, 31723-31730. Charged or Aromatic Anchor Residue Dependence of Transmembrane Peptide Tilt. (See this article)