施木德 - 中山大学 - 肿瘤防治中心

个人简介

2008年在中国科学院上海生化与细胞研究所获得博士学位,之后到美国南加州大学KECK医学院进行博士后研究.2015年作为中山大学”百人计划”人才引进回国，现为中山大学肿瘤防治中心华南肿瘤学国家重点实验室副研究员, 主要从事TRIM家族蛋白功能，肿瘤发生机制，肿瘤免疫疗法方面的研究。研究成果发表于Nat. Immunol.， Nat. Communications等国际顶级杂志，先后获得了全国优秀博士学位论文奖，上海市自然科学奖，国家自然科学二等奖等重要奖项。

研究领域

TRIM家族蛋白在肿瘤细胞中的功能；肿瘤免疫疗法

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation. Bowman J, Rodgers MA, Shi M, Amatya R, Hostager B, Iwai K, Gao SJ, Jung JU.MBio. 2015 Nov 17;6(6):e01777-15. doi: 10.1128/mBio.01777-15.　PMID:26578682　　Liang Q, Chang B, Lee P, Brulois KF, Ge J, Shi M, Rodgers MA, Feng P, Oh BH, Liang C, Jung JU. Identification of the essential role of vBcl2 for KSHV lytic replication. J Virol. 2015 Mar 4. pii: JVI.00102-15.Shi M, Cho H, Inn KS, Yang A, Zhao Z, Liang Q, Versteeg GA, Amini-Bavil-Olyaee S, Wong LY, Zlokovic BV, Park HS, García-Sastre A, Jung JU. Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9. Nat. Communications. 2014 Sep 5;5:4820. doi: 10.1038/ncomms5820.　　Liang Q, Seo GJ, Choi YJ, Ge J, Rodgers MA, Shi M, Jung JU. Autophagy side of MB21D1/cGAS DNA sensor. Autophagy. 2014 Jun;10(6):1146-7. doi: 10.4161/auto.28769.　　Rodgers MA, Bowman JW, Fujita H, Orazio N, Shi M, Liang Q, Amatya R, Kelly TJ, Iwai K, Ting J, Jung JU. The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation. J Exp Med. 2014 Jun 30;211(7):1333-47. doi: 10.1084/jem.20132486. Epub 2014 Jun 23.　　Liang Q, Seo GJ, Choi YJ, Kwak MJ, Ge J, Rodgers MA, Shi M, Leslie BJ, Hopfner KP, Ha T, Oh BH, Jung JU. Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses. Cell Host Microbe. 2014 Feb 12;15(2):228-38. doi: 10.1016/j.chom.2014.01.009.　　Liang Q, Chang B, Brulois KF, Castro K, Min CK, Rodgers MA, Shi M, Ge J, Feng P, Oh BH, Jung JU. Kaposi''s sarcoma-associated herpesvirus K7 modulates Rubicon-mediated inhibition of autophagosome maturation. J Virol. 2013 Nov;87(22):12499-503. doi: 10.1128/JVI.01898-13. Epub 2013 Sep 11.　　Amini-Bavil-Olyaee S, Choi YJ, Lee JH, Shi M, Huang IC, Farzan M, Jung JU. The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry. Cell Host Microbe. 2013 Apr 17;13(4):452-64. doi: 10.1016/j.chom.2013.03.006.　　Versteeg GA, Rajsbaum R, Sánchez-Aparicio MT, Maestre AM, Valdiviezo J, Shi M, Inn KS, Fernandez-Sesma A, Jung J, García-Sastre A. The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors. Immunity. 2013 Feb 21;38(2):384-98. doi: 10.1016/j.immuni.2012.11.013.　　Inn KS, Gack MU, Tokunaga F, Shi M, Wong LY, Iwai K, Jung JU.Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction. Mol Cell. 2011 Feb 4;41(3):354-65　　Deng W, Shi M, Han M, Zhong J, Li Z, Li W, Hu Y, Yan L, Wang J, He Y, Tang H, Deubel V, Luo X, Ning Q, Sun B.Negative regulation of virus-triggered IFN-beta signaling pathway by alternative splicing of TBK1.J Biol Chem. 2008 Dec 19;283(51):35590-7. Epub 2008 Oct 31. (共同第一作者)　　Shi M, Deng W, Bi E, Mao K, Ji Y, Lin G, Wu X, Tao Z, Li Z, Cai X, Sun S, Xiang C, Sun B. TRIM30alpha negatively regulates TLR-mediated NF-kappaB activation by targeting TAB2 and TAB3 for degradation. Nat Immunol. 2008 Apr;9(4):369-77. Epub 2008 Mar 16.　　Wu X, Hou W, Sun S, Bi E, Wang Y, Shi M, Zang J, Dong C, Sun B. Novel function of IFN-gamma: negative regulation of dendritic cell migration and T cell priming. J Immunol. 2006 Jul 15;177(2):934-43.　　Lu W, Wu XD, Shi MD, Yang RF, He YY, Bian C, Shi TL, Yang S, Zhu XL, Jiang WH, Li YX, Yan LC, Ji YY, Lin Y, Lin GM, Tian L, Wang J, Wang HX, Xie YH, Pei G, Wu JR, Sun B. Synthetic peptides derived from SARS coronavirus S protein with diagnostic and therapeutic potential. FEBS Lett. 2005 Apr 11;579(10):2130-6. (共同第一作者