个人简介
2005年毕业于中山大学中山医学院,获医学学士学位,同年免试进入中山大学肿瘤防治中心硕博连读,2010年获肿瘤学博士学位,2012年进入生物治疗中心工作,主攻肿瘤生物治疗、黑色素瘤内科治疗。近年来主要从事自噬与肿瘤的研究,目前发表SCI研究论文19篇,其中单篇最高被引用次数近100次。作为项目负责人先后主持国家级、省部级及校级等各类科研基金6项,并作为主要成员参与多项国家及省部级科研项目。 2005/09 – 2010/06,中山大学,肿瘤防治中心,肿瘤学博士,导师朱孝峰教授 2000/09 – 2005/06,中山大学北校区,医学学士 工作经历 2015/01 – 至今,中山大学,肿瘤防治中心生物治疗中心,助理研究员,主治医师 2012/08 – 2014/12,中山大学,肿瘤防治中心生物治疗中心,助理研究员,医师 2010/09 – 2012/07,中山大学,肿瘤防治中心,博士后,合作导师张晓实教授
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1. D-D Li#, L-L Wang#, R Deng, J Tang, Y Shen, J-F Guo, Y Wang, L-P Xia, G-K Feng, QQ Liu, W-L Huang, Y-X Zeng and X-F Zhu. The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells. Oncogene, 2009; 28: 886-98. 2. Dan-Dan Li, Xiao-Qi Wu, Jun Tang, Xiao-Yi Wei, Xiao-Feng Zhu. ON-III inhibits erbB-2 tyrosine kinase tyrosine tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells. Cancer Biology & Therapy, 2009 Apr; 8 (8): 739-43. 3. Dan-Dan Li, Jing-Feng Guo, Lin-Lin Wang, Rong Deng, Jian-nan Liu, Gong-Kan Feng, Ding-Jun Xiao, Song-Zhi Deng, Xiao-shi Zhang, Xiao-Feng Zhu. Rhabdastrellic acid-A induced autophagy -associated cell death through blocking Akt pathway in human cancer cells. PLos one, 2010; 17; 5 (8):e12176. 4. Sun T#, Li DD#(共同第一作者), Wang LL, Xia LP, Ma JG, Guan Z, Feng GK, Zhu XF. c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells. J Transl Med, 2011 Sep 26; 9 (1):161. 5. Li DD, Sun T, Wu XQ, Chen SP, Deng R, Jiang S, Feng GK, Pan JX, Zhang XS, Zeng YX, Zhu XF. The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment. PLos one, 2012; 7 (9): e45058. 6. Jing-Hong Chen#, Peng Zhang#, Wen-Dan Chen#, Dan-Dan Li, Xiao-Qi Wu, Rong Deng, Lin Jiao, Xuan Li, Jiao Ji, Gong-Kan Feng, Yi-Xin Zeng, Jian-Wei Jiang, Xiao- Feng Zhu. Autophagy, 2015; Feb 20. 7. Shen Y, Li DD, Wang LL, Deng R, Zhu XF. Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer. Autophagy, 2008; 4: 1067-8.