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个人简介

2007年毕业于南华大学医学院临床医学系,2013年获中山大学肿瘤学博士学位,2016-2017年获国家留学基金委资助公派到美国MD安德森癌症中心访问交流一年。近年来围绕“鼻咽癌分子预后及转移分子机制”开展了系列应用基础研究,以(共同)第一/通讯作者身份发表SCI收录论著28篇,包括Lancet Oncol (2篇)、Nat Commun、Theranostics、Int J Cancer、PLoS Genet、Cancer Lett、Cell Death Dis等。研究工作获得了中华医学科技一等奖、高等学校科技进步一等奖、广东省科学技术一等奖(鼻咽癌个体化治疗研究与应用,2014年,均为第11 完成人);并荣获广东省“南粤创新奖”(中山大学广东省(鼻咽癌)研究诊治团队,2016年,第8完成人)。

研究领域

肿瘤分子预后及转移分子机制

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1.Tang XR,# Li YQ,# Liang SB,# Jiang W,# Liu F,# Ge WX, Tang LL, He QM, Yang XJ, Zhang Y, Wen X, Zhang J, Wang YQ, Zhang PP, Sun Y, Yun JP, Zeng J, Li L, Liu LZ, Liu N,* Ma J.* Development and validation of a gene expression-based signature to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma: a multicenter study. Lancet Oncol, 2017; Accepted. 2.Liu N,# Chen NY,# Cui RX,# Li WF, Li Y, Wei RR, Zhang MY, Sun Y, Huang BJ, Chen M, He QM, Jiang N, Chen L, Cho WC, Yun JP, Zeng J, Liu LZ, Li L, Guo Y, Wang HY,* Ma J.* Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol, 2012; 13(6): 633-641. 3.Ren XY,# Yang XJ,# Cheng B,# Chen XZ,# Zhang TP, He QM, Li B, Li YQ, Tang XR, Wen X, Zhong Q, Kang TB, Zeng MS, Liu N,* Ma J.* HOPX hypermethylation promotes metastasis via activating SNAIL transcription and correlates with poor prognosis in NPC. Nat Commun, 2017; 8: 14053. 4.Chen YP,# Zhang Y,# Lv JW,# Li YQ,# Wang YQ, He QM, Yang XJ, Sun Y, Mao YP, Yun JP, Liu N,* Ma J.* Genomic analysis of tumor microenvironment immune types across 14 solid cancer types: immunotherapeutic implications. Theranostics, 2017; 7(14): 3585-3594. 5.Liu N,# Cui RX,# Sun Y,# Guo R, Mao YP, Tang LL, Jiang W, Liu X, Cheng YK, He QM, Cho WCS, Liu LZ, Li L, Ma J.* A four-miRNA signature identified from genome-wide serum miRNA profiling predicts survival in nasopharyngeal carcinoma. Int J Cancer, 2014; 134 (6): 1359-1368. 6.Xu YF,# Mao YP,# Li YQ, Ren XY, He QM, Tang XR, Sun Y, Liu N,* Ma J.* MicroRNA-93 promotes cell growth and invasion in nasopharyngeal carcinoma by targeting Disabled homolog-2. Cancer Lett, 2015; 363(2): 146-155. 7.Liu N,# Tang LL,# Sun Y,# Cui RX, Wang HY, Huang BJ, He QM, Jiang W, Ma J.* MiR-29c suppresses invasion and metastasis by targeting TIAM1 in nasopharyngeal carcinoma. Cancer Lett, 2013; 329(2): 181-188. 8.Liu N,# He QM,# Chen JW,# Li YQ, Xu YF, Ren XY, Sun Y, Mai HQ, Shao JY, Jia WH, Kang TB, Zeng MS, Ma J.* Overexpression of CIP2A is an independent prognostic indicator in nasopharyngeal carcinoma and its depletion suppresses cell proliferation and tumor growth. Mol Cancer, 2014; 13(1): 111. 9.Liu N,# Jiang N,# Guo R,# Jiang W, He QM, Xu YF, Li YQ, Tang LL, Mao YP, Sun Y, Ma J.* MiR-451 inhibits cell growth and invasion by targeting MIF and is associated with survival in nasopharyngeal carcinoma. Mol Cancer, 2013; 12(1): 123. 10.Li YQ,# Tang XR,# He QM,# Yang XJ, Ren XY, Ren XY, Wen X, Zhang J, Wang YQ, Liu N,* Ma J.* Overexpression of mitochondria mediator gene TRIAP1 by miR-320b loss is associated with progression in nasopharyngeal carcinoma. PLoS Genet, 2016; 12(7): e1006183. 11.Tang XR,# Wen X,# He QM,# Li YQ, Ren XY, Yang XJ, Zhang J, Wang YQ, Ma J, Liu N.* MicroRNA-101 inhibits invasion and angiogenesis through targeting ITGA3 and its systemic delivery inhibits lung metastasis in nasopharyngeal carcinoma. Cell Death Dis, 2017; 8(1): e2566. 12.Li YQ,# Ren XY,# He QM, Xu YF, Tang XR, Sun Y, Zeng MS, Kang TB, Liu N,* Ma J.* MiR-34c suppresses tumor growth and metastasis in nasopharyngeal carcinoma by targeting MET. Cell Death Dis, 2015; 6: e1618. 13.Jiang W,# Liu N,# Chen XZ,# Sun Y,# Li B, Ren XY, Qin WF, Jiang N, Xu YF, Li YQ, Ren J, Cho WC, Yun JP, Zeng J, Liu LZ, Li L, Guo Y, Mai HQ, Zeng MS, Kang TB, Jia WH, Shao JY, Ma J.* Genome-wide Identification of a Methylation Gene Panel as a Prognostic Biomarker in Nasopharyngeal Carcinoma. Mol Cancer Ther, 2015; 14(12): 2864-2873. 14.Zhang J,# Wen X,# Ren XY, Li YQ, Tang XR, Wang YQ, He QM, Yang XJ, Sun Y, Liu N,* Ma J.* YPEL3 suppresses epithelial-mesenchymal transition and metastasis of nasopharyngeal carcinoma cells through the Wnt/β-catenin signaling pathway. J Exp Clin Cancer Res, 2016; 35(1): 109. 15.He QM,# Ren XY,# Chen JW,# Li YQ, Tang XR, Wen X, Yang XJ, Zhang J, Wang YQ, Ma J, Liu N.* miR-16 targets fibroblast growth factor 2 to inhibit NPC cell proliferation and invasion via PI3K/AKT and MAPK signaling pathways. Oncotarget, 2016; 7(3): 3047-3058. 16.Li YQ,# Li WF,# He QM, Xu YF, Ren XY, Tang XR, Wen X, Yang XJ, Sun Y, Zeng J, Yun JP, Liu N,* Ma J.* Prognostic value of MET protein overexpression and gene amplification in locoregionally advanced nasopharyngeal carcinoma. Oncotarget, 2015; 6(15): 13309-13319. 17.Chen YP,# Zhang WN,# Chen L,# Tang LL, Mao YP, Li WF, Liu X, Zhou GQ, Sun Y, Kang TB, Zeng MS, Liu N,* Ma J.* Effect of latent membrane protein 1 expression on overall survival in Epstein-Barr virus -associated cancers: a literature-based meta-analysis. Oncotarget, 2015; 6(30): 29311-29323. 18.Ren XY,# Zhou GQ,# Jiang W,# Sun Y, Xu YF, Li YQ, Tang XR, Wen X, He QM, Yang XJ, Liu N,* Ma J.* Low SFRP1 expression correlates with poor prognosis and promotes cell invasion by activating the Wnt-β-catenin signaling pathway in NPC. Cancer Prev Res, 2015; 8(10): 968-977.

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