个人简介
分子医学/肿瘤学和药物化学博士生导师，从事抗肿瘤代谢和表观遗传药物合成及机制研究。吉林大学化学系本科毕业，中国科学院上海有机化学研究所博士毕业。2005年至2010年曾在英国南安普顿大学和剑桥大学进行博士后研究。目前，主持多项国家级和省部级项目。在Leukemia, Mol Cancer, Cancer Lett, Future Med Chem, Eur J Med Chem, J Med Chem, Angew Chem Int Ed, Adv Synth Catal, Organic Letters, Chem Eur J等杂志上发表SCI论文50多篇。近年来，发表第一和通讯作者SCI论文近30篇，其中IF>5的SCI论文有12篇，两项研究工作(Chem Eur J 2015，Org Lett 2014) 被国际引文杂志SYNFACTS专门评论。申请发明专利11项，其中获得授权3项、国际PCT专利1项。 工作经历： 1. 2017/12-至今：研究员，博士生导师，中山大学肿瘤防治中心，从事抗肿瘤代谢和表观遗传药物合成及机制研究 2. 2010/10–2017/12：副研究员，中山大学肿瘤防治中心 3. 2008/02–2010/05: 博士后，英国剑桥大学化学系和生物化学系，从事结核菌泛酸合成酶抑制剂研究 4. 2005/06–2008/01: 博士后，英国南安普敦大学医学院和化学系，从事组蛋白去乙酰酶抑制剂研究
近期论文
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1.Zhu D, Wu Z, Luo B, Du Y, Liu P, Chen Y, Hu Y, Huang P*, Wen S*. Heterocyclic Iodoniums for the Assembly of Oxygen-Bridged Polycyclic Heteroarenes with Water as the Oxygen Source. Organic Letters 2018 Jul 27. doi: 10.1021/acs.orglett.8b01969. [Epub ahead of print] (IF 6.492) 2.Guo-Xin Hou, Pan-pan Liu, Mengqi Yang, Jianwei Liao, Jing Yang, Yumin Hu, Wen-Qi Jiang, Shijun Wen,* Peng Huang* Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis Cell Death Disease, 2018 Jan 24;9(2):89. (IF 5.638) 3.Saha N, Wang H, Zhang S, Du Y, Zhu D, Hu Y, Huang P*, Wen S*. Domino Carbopalladation/ C-H Activation as A Quick Access to Polycyclic Frameworks, Organic Letters 2018 Feb 2;20(3):712-715. (IF 6.492) 4.Shijun Wen,* Jiankang Wang, Panpan Liu, Yiqing Li, Wenhua Lu, Yumin Hu, Jinyun Liu, Zhiyuan He, Peng Huang.* Novel combination of histone methylation modulators with therapeutic synergy against acute myeloid leukemia in vitro and in vivo Cancer Lett. 2018 Jan 28; 413: 35-45. (IF 6.491) 5.Tang Gao，Xiaozheng Cao， Anyao Bi，Jie Dong，Shuai Huang，Xueyan Huang，Shijun Wen，Wenbin Zeng. An Aza-Cope mediated fluorescent probe based on aggregation-induced emission for highly selective and sensitive detection of formaldehyde in living cells and tissues, Sensors and Actuators B: Chemical, 2018 Nov; 273: 1139-1145. (IF 5.667) 6.Zhang T, Zhao M, Lu D, Wang S, Yu F, Guo L, Wen S, Wu B, REV-ERBa Regulates CYP7A1 through Repression of Liver Receptor Homolog-1, Drug Metab Dispos. 2018 Mar; 46(3): 248-258. ( IF 3.640) 7.Li Y, Shi Q, Shao J, Yuan Y, Yang Z, Chen S, Zhou X, Wen S, Jiang ZX. Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives. Eur J Med Chem. 2018 Mar 25; 148: 279-290.（IF 4.816） 8.Shao J, Glorieux C, Liao J, Chen P, Lu W, Liang Z, Wen S, Hu Y, Huang P. Impact of Nrf2 on tumour growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo. Free Radic Res. 2018 Jun; 52(6): 661-671.（IF 3.038） 9.Jiankang Wang, Bingling Luo, Xiaobing Li, Jing Yang, Wenhua Lu, Yumin Hu, Peng Huang*, Shijun Wen*, Inhibition of cancer growth in vitro and in vivo by a novel ROS-modulating agent with ability to eliminate stem-like cancer cells. Cell Death Disease, 2017, 8(6):e2887. (IF 5.638) 10.Xiaopeng Peng, Hongwen Luo, Fuhai Wu, Daqian Zhu, A. Ganesan, Peng Huang, Shijun Wen*, Synthesis of Fluorenes with an All-Carbon Quaternary Center via Palladium- Catalyzed Dual Arylation using Cyclic Diaryliodonium Triflates. Adv Synth Catal, 2017, 359, 1152-1156. (IF 5.123) 11.Bingling Luo, Jiankang Wang, Xiaobing Li, Jing Yang, Wenhua Lu, Yumin Hu, Peng Huang, Shijun Wen*, New Mild and Simple Approach to Isothiocyanates: A Class of Potent Anticancer Agents. Molecules, 2017, 22(6). pii: E773. (IF 3.098) 12.GX Hou, P Liu, J Yang, S Wen*, Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter. PLoS One, 2017, 12(3): e0174515. (IF 2.766) 13.Qingbin Cui#, Shijun Wen#, Peng Huang*, Targeting cancer cell mitochondria as a therapeutic approach: recent updates, Future Med Chem, 2017, 9(9):929-949. (IF 3.969) 14.H-Q Ju, G Zhan, A Huang, Y Sun, S Wen, J Yang, W-h Lu, R-h Xu, J Li, Y Li, G Garcia-Manero, P Huang*, Y Hu* ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition, Leukemia, 2017 Oct;31(10):2143-2150 . (IF 10.023) 15.Jianwei Liao, Pan-Pan Liu, Guoxin Hou, Jiajia Shao, Jing Yang, Kaiyan Liu, Wenhua Lu, Shijun Wen, Yumin Hu, Peng Huang*, Regulation of stem-like cancer cells by glutamine through beta-catenin pathway mediated by redox signaling, Molecular Cancer, 2017, 16(1): 51 DOI 10.1186/s12943-017-0623-x. (IF 7.776) 16.Mengqi Yang, Panpan Liu, Kefeng Wang, Christophe Glorieux, Yumin Hu, Shijun Wen, Wenqi Jiang*, Peng Huang*, Chemotherapy induces tumor immune evasion by upregulation of programmed cell death ligand 1 expression in bone marrow stromal cells, Molecular Oncology, 2017, 11(4):358-372. (IF 5.264) 17.Kaiyan Liu, Zhenjie Tang, Amin Huang, Ping Chen, Panpan Liu, Jing Yang, Wenhua Lu, Jianwe Liao, Yicheng Sun, Shijun Wen, Yumin Hu,* Peng Huang*, Glyceraldehyde-3- phosphate dehydrogenase promotes cancer growth and metastasis through upregulation of SNAIL expression, Int J Oncol, 2017, 50 (1): 252-262. (IF 3.333)
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