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个人简介

1989年毕业于南京大学生物化学系(本科),1998年获得同济医科大学生物化学与分子生物学专业硕士学位,2007年获得中山大学肿瘤学博士学位。现任中山大学肿瘤防治中心、华南肿瘤学国家重点实验室研究员、教授。 学术兼职: 广东省药理学会肿瘤药理专业委员会常务委员(2014.10-2018.10);广东省抗癌协会抗肿瘤药物专业委员会委员(2016.11~2019.11);广东省临床医学学会精准医疗专业委员会委员(2017.9-2020.9);广东省肝脏病学会微创外科及生物治疗专业委员会委员(2007.1-至今)。 海外留学: 2008年2月-2009年9月在美国印第安纳大学医学院进修(博士后),主要从事肿瘤放化疗耐受机制及DNA损伤修复蛋白翻译调控的研究。

研究领域

恶性肿瘤的靶向治疗研究,通过分子机制研究寻找肿瘤治疗的靶点或靶基因,有针对性地进行靶向治疗药物或技术的研究。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. ARHGEF19 interacts with BRAF to activate MAPK signaling during the tumorigenesis of non-small cell lung cancer. Int J Cancer. 2017 Nov 22. doi: 10.1002/ijc.31169. 2. BST2 confers cisplatin resistance via NF-κB signaling in nasopharyngeal cancer. Cell Death Dis. 2017; 8: e2874. 3. The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells. Chin J Cancer 2017; 36: 11. 4. ZD6474, a new treatment strategy for human osteosarcoma, and its potential synergistic effect with celecoxib. Oncotarget. 2015; 6: 21341-52. 5. Overexpression of asparagine synthetase and matrix metalloproteinase 19 confers cisplatin sensitivity in nasopharyngeal carcinoma cells. Mol Cancer Ther. 2013; 12:2157-66. 6. Antitumor efficacy of a recombinant adenovirus encoding endostatin combined with an E1B55KD-deficient adenovirus in gastric cancer cells. J Transl Med. 2013; 11:257. 7. Adenovirus-mediated delivery of interferon-γ gene inhibits the growth of nasopharyngeal carcinoma. J Transl Med. 2012; 10: 256. 8. Role of eIF3a in regulating cisplatin sensitivity and in translational control of nucleotide excision repair of nasopharyngeal carcinoma. Oncogene. 2011;30:4814-23 9. Elevated serum LAMC2 increases the risk of lymph node metastasis and predicts a poor prognosis in penile squamous cell carcinoma. Submitted, 2017 10. Molecular characterization and integrative genomic analysis of a panel of newly established penile cancer cell lines. Submitted, 2017

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