个人简介
1984年毕业于上海医科大学医学系(本科)。1988年获上海医科大学附属华山医院临床医学硕士;1994年在荷兰Leiden大学医学院获免疫学博士。1999年被瑞典国家研究院聘为助理教授。2004年获国家杰出青年基金,2005年获国务院政府特殊津贴,2008年被聘为教育部“长江学者”特聘教授。 现任中山大学生命科学院副院长;国家自然科学基金委学科评审组(二审)专家。 海外留学经历: 1990年赴荷兰Leiden大学医学院学习并于1994年获免疫学博士;随后在瑞典Linkoping大学医学院和Lund大学Malmo总医院做博士后,1999年被瑞典国家研究院聘为助理教授。
研究领域
从事肿瘤免疫逃逸机制以及肿瘤生物治疗的研究。以肝癌为主要模型,阐明间质免疫细胞(土壤)与癌细胞(种子)之间的相互作用和潜在机制,探讨以间质免疫细胞作为肿瘤分子分期和治疗靶标的可行性。
近期论文
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1. DM Kuang, C Peng, Q Zhao, Y Wu, MS Chen, and L Zheng. Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory Th17 cells. Hepatology, 2009, In press. DOI: 10.1002/hep.23291 2. R Tao, L Li, W Huang, and L Zheng. Activation of human dendritic cells by recombinant modified vaccinia virus Ankara vectors encoding Survivin and IL-2 genes in vitro. Hum Gene Ther. 2009. In press 3. J Zhou, T Ding, W Pan, LY Zhu, L Li, and L Zheng. Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients. Int. J. Cancer. 2009. 125:1640-8. 4. DM Kuang, QY Zhao, C Peng, J Xu, JP Zhang, C Wu, and L Zheng. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J. Exp. Med. 2009 206: 1327-1337. 5. J-P Zhang, J Yan, J Xu, XH Pang, MS Chen, L Li, C Wu, SP Li, and L Zheng. Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J. Hepatol. 2009, 50:980-9 6. T Ding, J Xu, F Wang, M Shi, Y Zhang, S-P Li, and L Zheng. High tumor infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma following resection. Human Pathol, 2009, 40:381-9. 7. DM Kuang, Q Zhao, J Xu, JP Yun, C Wu, and L Zheng. Tumor-educated tolerogenic dendritic cells induce CD3ε down-regulation and apoptosis of T cells through oxygen-dependent pathways. J. Immunol. 2008, 181:3089-98. 8. DM Kuang, Y Wu, N Chen, J Cheng, SM Zhuang, and L Zheng. Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes. Blood. 2007. 110:587-95. 9. J Cheng, DH Huo, DM Kuang, J Yang, L Zheng*, and SM Zhuang*. Human macrophage promotes the motility and invasiveness of Osteopontin-knockdown tumor cells. Cancer Res. 2007. 67: 5141-7. (* co-corresponding authors)