个人简介
学习及工作经历 1980年-1986年,中山医科大学医学系; 1986年-1992年,中山大学肿瘤医院放射治疗科住院医师; 1993年-2001年,中山大学肿瘤医院放射治疗科主治医师; 1998年-1999年,香港中文大学威尔斯亲王医院进修; 2001年-2009年,中山大学肿瘤医院放射治疗科副主任医师; 2009年-2010年,中山大学肿瘤医院放射治疗科主任医师; 2010年-现在,中山大学肿瘤医院鼻咽科主任医师。
研究领域
从事放射治疗的基础与临床研究近30年,主要研究方向为头颈肿瘤和鼻咽癌的诊断、放射治疗和综合治疗;2001年在国内最早开展鼻咽癌调强适形放疗以及鼻咽癌放射治疗靶区的研究工作;目前主要专注于鼻咽癌调强放疗的个体化实施、局部晚期鼻咽癌放疗和化疗的个体化综合治疗、局部复发和转移鼻咽癌的治疗以及头颈部放射损伤的防治。
近期论文
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1、 Distant metastasis risk and patterns of nasopharyngeal carcinoma in the era of IMRT: long-term results and benefits of chemotherapy. Oncotarget, www.impactjournals.com/oncotarget 2、 Risk factors and prediction-score model for distant metastasis in nasopharyngeal carcinoma treated with intensity-modulated radiotherapy. Tumor Biology, DOI 10.1007/s13277-015-3574-0 3、 Positron emission tomography–computed tomography before treatment is highly prognostic of distant metastasis in nasopharyngeal carcinoma patients after. Oral Oncology, 2015, 51:363-369 4、 Analysis of late toxicity in nasopharyngeal carcinoma patients treated with intensity modulated radiation therapy. Radiation Oncology, 2015, 10:17 5、 Activating enhancer-binding protein-2α induces cyclooxygenase-2 expression and promotes nasopharyngeal carcinoma growth. Oncotarget, 2015, 6(7): 5005-5021 6、 Comprehensive treatment of squamous cell cancer of head and neck-Chinese expert consensus. Future Oncology, 2014, 10(9):1635-1648 7、 Effect of total dose and fraction size on survival of patients with locally recurrent nasopharyngeal carcinoma treated with intensity-modulated radiotherapy: A phase 2, single-Center, randomized controlled trial. Cancer, 2014, 120(22):3502-3509 8、 Results of a phase II study examining the effects of omitting elective neck irradiation to nodal levels IV and Vb in patients with N0-1 nasopharyngeal carcinoma. International Journal of Radiation Oncology* Biology* Physics, 2013, 85(4):929-934 9、 Long-term Follow-up of a Phase III Study Comparing Radiotherapy with or without Weekly Oxaliplatin for LocoregionallyAdvanced Nasopharyngeal Carcinoma. Annals Oncology,2013,24:2131-2136 10、 Long-term Treatment Outcome of Recurrent Nasopharyngeal Carcinoma Treated with Salvage Intensity Modulated Radiotherapy. European Journal of Cancer, 2012,48:3422-3428 11、 疗前FDG 标准摄取值预测局部晚期鼻咽癌调强放疗疗效的探讨. 中华放射肿瘤学杂志,2012,21(3):209-213 12、 Intensity-Modulated Radiation Therapy Reduces Radiation-induced Trismus in Patients with Nasopharyngeal Carcinoma--A Prospective Study With 5 Years of Follow-Up. Cancer,2011,117(13):2910-2916 13、 Local Control, Survival,and Late Toxicities of Locally Advanced Nasopharyngeal Carcinoma Treated by Simultaneous Modulated Accelerated Radiotherapy Combined with CisplatinConcurrent Chemotherapy. Cancer, 2011,117(9):1874-1883 14、 Different Clinical Significance of Pre- and Post-treatment Plasma Epstein–Barr Virus DNA Load in Nasopharyngeal Carcinoma Treated with Radiotherapy. Clinical Oncology,2011,23:128-133 15、 The Role of Concurrent Chemoradiotherapy in the Treatment of Locoregionally Advanced Nasopharyngeal Carcinoma among Endemic Population A Meta-analysis of the Phase III Randomized Trials. BMC Cancer,2010,10:558