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个人简介

【教育背景】  2001.08-2004.07 香港大学-医学院,临床肿瘤学系博士学位  1993.09-1996.07 中山大学-中山医学院,病理学系硕士学位  1986.09-1991.07 中南大学-湘雅医学院,临床医学系本科【工作经历】   2007.12-至今 中山大学肿瘤防治中心,教授,博士生导师,华南肿瘤学国家重点实验室,课题组长(PI)     2005.05-2007.12 中山大学肿瘤防治中心,副教授,博士生导师(2006.10)  2004.08-2005.05 中山大学中山医学院,副教授,硕士生导师  1999.09-2001.07 香港大学医学院,研究助理(Research associate)  1996.07-1999.09 中山大学中山医学院,助教、讲师

研究领域

1. 恶性肿瘤侵袭转移分子机制 2. 肿瘤标志物和早期诊断 3. 肿瘤分子分型和基因治疗

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1.Zhang JX, Song W, Chen ZH, Wei JH, Liao YJ, Lei J, Hu M, Chen GZ, Liao B, Lu J, Zhao HW, Chen W, He YL, Wang HY, Xie D*, Luo JH*. Prognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis. Lancet Oncol. (IF:24.69) 2013 Dec;14(13):1295-306.  2.Zhu W, Cai MY, Tong ZT, Dong SS, Mai SJ, Liao YJ, Bian XW, Lin MC, Kung HF, Zeng YX, Guan XY, Xie D*. Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating?MTA1 through c-myc to induce epithelial-mesenchymal transition. Gut. (IF:14.66) 2012;61(4):562-75.  3.Zheng F, Liao YJ, Cai MY, Liu YH, Liu TH, Chen SP, Bian XW, Guan XY, Lin MC, Zeng YX, Kung HF, Xie D*. The putative tumor suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut. (IF:14.66) 2012;61(2):278-89.  4.Cai MY, Tong ZT, Zheng F, Liao YJ, Wang Y, Rao HL, Chen YC, Wu QL, Liu YH, Guan XY, Lin MC, Zeng YX, Kung HF, Xie D*. EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies. Gut. (IF:14.66) 2011;60(7):967-76.  5.Xu C, Xie D (co-first), Yu S, Yang X, He, Yang J, Ping Y, Wang B, Yang L, Xu S, Cui W, Wang Q, Fu W, Liu Q, Qian C, Cui Y, Rich JN, Kung HF, Zhang X*, Bian XW*. A novel complex of β-catenin/POU5F1/SOX2 is responsive and dependent on IGF-1R signaling for prediction of poor prognosis in lung adenocarcinoma. Cancer Res. (IF: 9.329) 2013 May 15;73(10):3181-9.  6.Qian D, Chen K, Deng H, Rao HL, Huang HQ, Liao YJ, Sun X, Lu S, Yuan Z, Xie D*, Cai Q. MicroRNA-374b suppresses proliferation and promotes apoptosis in T-cell lymphoblastic lymphoma by repressing AKT1 and Wnt-16. Clin Cancer Res. (IF:8.722) 2015 Jun 22.. [Epub ahead of print]  7.Tong ZT, Cai MY, Wang XG, Kong LL, Mai SJ, Liu YH, Zhang HB, Liao YJ, Zheng F, Zhu W, Liu TH, Bian XW, Guan XY, Lin MC, Zeng MS, Zeng YX, Kung HF, Xie D*. EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. Oncogene. (IF:8.459) 2012;31(5):583-94.  8.Zhang B, Qian D, Ma HH, Jin R, Yang PX, Cai MY, Liu YH, Liao YJ, Deng HX, Mai SH, Zhang H, Zeng YX, Lin MC, Kung HF*, Xie D*, Huang JJ*. Anthyracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitinization and degradation. Oncogene. (IF:8.459) 2012;31(1):1-12.  9.Zheng F, Liao YJ, Cai MY, Liu TH, Chen SP, Wu PH, Wu L, Bian XW, Guan XY, Zeng YX, Yuan YF, Kung HF, Xie D*. Systemic delivery of microRNA-101 potently inhibits hepatocellular carcinoma in vivo by repressing multiple targets. PLoS Genet. (IF:7.528) 2015 Feb 18;11(2):e1004873  10.Qian D, Zhang B, He LR, Cai MY, Mai SJ, Liao YJ, Liu YH, Lin MC, Bian XW, Zeng YX, Huang JJ, Kung HF, Xie D*. The Telomere/Telomerase Binding Factor PinX1 is a New Target to Improve the Radiotherapy Effect of Esophageal Squamous Cell Carcinomas. J Pathol. (IF:7.429) 2013 Apr;229(5):765-74.  11. Dai T, Zhang D, Cai M, Wang C, Wu Z, Ying Z, Wu J, Li M, Xie D*, Li J*, Song L*. Golgi phosphoprotein 3 (GOLPH3) promotes hepatocellular carcinoma cell aggressiveness by activating the NF-κB pathway. J Pathol. (IF:7.429) 2015 Feb;235(3):490-501.  12.Zhang JX, Mai SJ, Huang XX, Wang FW, Liao YJ, Lin MC, Kung HF, Zeng YX, Xie D*. MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of β-catenin signaling. Ann Oncol. (IF:7.04) 2014 Nov;25(11):2196-204.  13.He LR, Zhao HY, Li BK, Zhang LJ, Liu MZ, Kung HF, Guan XY, Bian XW, Zeng YX, Xie D*. Overexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung cancer patients. Ann Oncol. (IF:7.04) 2010;21(8):1675-81.  14.Wang FW, Cai MY, Mai SJ, Chen JW, Bai HY, Li Y, Liao YJ, Li CP, Tian XP, Kung HF, Guan XY, Xie D*. Ablation of EIF5A2 induces tumor vasculature remodeling and improves tumor response to chemotherapy via regulation of matrix metalloproteinase 2 expression. Oncotarget. (IF:6.359) 2014 Aug 30;5(16):6716-33.  15.He LR, Ma NF, Chen JW, Li BK, Guan XY, Liu MZ, Xie D*. CHD1L overexpression is associated with tumor metastasis and poor survival in patients with lung adenocarcinoma. Oncotarget. (IF:6.359) 2015 Aug in press.  16.Tian XP, Qian D, He LR, Huang H, Mai SJ, Li CP, Huang XX, Cai MY, Liao YJ, Kung HF, Zeng YX, Xie D*. The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas. Cancer Lett. (IF:5.621) 2014 Oct 10;353(1):104-14.  17.Zhang JX, Qian D, Wang FW, Liao DZ, Wei JH, Tong ZT, Fu J, Huang XX, Liao YJ, Deng HX, Zeng YX, Xie D*, Mai SJ*. MicroRNA-29c enhances the sensitivities of human nasopharyngeal carcinoma to cisplatin-based chemotherapy and radiotherapy. Cancer Lett. (IF:5.621) 2013;329(1):91-8.  18.Chen Y, Xie D (co-first), Yin Li W, Man Cheung C, Yao H, Chan CY, Chan CY, Xu FP, Liu YH, Sung JJ, Kung HF*. RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo. Cancer Lett. (IF:5.621) 2010;297(1):109-16.

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