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个人简介

朱孝峰,男,1970年9月出生,博士, 教授,博士生导师。中山大学肿瘤防治中心华南肿瘤学国家重点实验室副主任,主要从事肿瘤信号转导、自噬调控与靶向药物研究。2000年在美国乔治城大学癌症中心学习,2002年获中国药理学会施维雅青年药理学工作者奖,2007年入选教育部新世纪优秀人才支持计划,现为广东省抗癌协会抗肿瘤药物专业委员会候任主任委员,广东省肿瘤药理专业委员会主任委员,中国抗癌协会抗癌药物专业委员会委员,中国药理学会肿瘤药理及化疗专业委员会委员,Chin J Cancer、Front Pharmacol、Advances in Therapy等杂志编委。先后承担国家自然科学基金重点项目1项,面上项目7项、973计划课题(组长)1项、973计划课题(骨干)1项以及863计划、省市科技项目等多项课题,发表SCI收录论文90余篇,以通讯作者发表SCI收录论文40余篇包括Nature Communications, Leukemia, Autophagy, Oncogene(4篇)等国际著名杂志,主编人民卫生出版社出版的《信号转导与疾病》和广东科技出版社出版《肿瘤生物治疗学》等专著,申请新药发明专利九项,其中五项已获授权,研发的抗肿瘤新药阿诺宁注射液已转让企业开发。

研究领域

肿瘤信号转导、自噬调控与靶向药物研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Ting Sun, Xuan Li, Peng Zhang, Wen-Dan Chen, Hai-Liang Zhang, Dan-Dan Li, Rong Deng, Xiao-Jun Qian, Lin Jiao, Jiao Ji, Yuan-Tian Li, Rui-Yan Wu, Yan Yu, Gong-Kan Feng, Xiao-Feng Zhu*. Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. Nat Commun. 2015; 6: 7215.   2. Jing-Hong Chen, Peng Zhang, Wen-Dan Chen, Dan-Dan Li, Rong Deng, Xuan Li, Jiao Ji, Gong-Kan Feng, Yi-Xin Zeng, Jian-Wei Jiang, Xiao-Feng Zhu*. ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to topotecan in cancer cells. Autophagy, 2015; 11(2): 239-52   3. Xu XL, Cheng H, Tang MS, Zhang HL, Wu RY, Yu Y, Li X, Wang XM, Mai J, Yang CL, Jiao L, Li ZL, Zhong ZM, Deng R, Li JD, Zhu XF*. A novel nomogram based on LODDS to predict the prognosis of epithelial ovarian cancer. Oncotarget, 2016 Dec 22. doi: 10.18632/oncotarget.14100. [Epub ahead of print]   4. Huang L, Lan WJ, Deng R, Feng GK, Xu QY, Hu ZY, Zhu XF*, Li HJ. Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K-M from the Marine Fungus Chondrostereum sp. Mar Drugs, 2016;14(9). pii: E157.   5. Jiao L, Li DD, Yang CL, Peng RQ, Guo YQ, Zhang XS, Zhu XF*. Reactive oxygen species mediate oxaliplatin-induced epithelial-mesenchymal transition and invasive potential in colon cancer. Tumour Biol. 2016;37(6):8413-23.   6. Lu QP, Chen WD, Peng JR, Xu YD, Cai Q, Feng GK, Ding K, Zhu XF*, Guan Z. Antitumor activity of 7RH, a discoidin domain receptor 1 inhibitor, alone or in combination with dasatinib exhibits antitumor effects in nasopharyngeal carcinoma cells. Oncol Lett, 2016;12(5):3598-3608.   7. Xiao-jun Qian, Yun-tian Li, Yan Yu, Yang Fen, Rong Deng, Jiao Ji, Lin Jiao, Xuan Li, Rui-Yan Wu, Wen-Dan Chen, Gong-Kan Feng, Xiao-Feng Zhu*. Inhibition of DNA Methyltransferase as a Novel Therapeutic Strategy to Overcome Acquired Resistance to Dual PI3K/mTOR Inhibitors. Oncotarget. 2015; 6(7): 5134-46   8. Juan Qin, Jiao Ji, Rong Deng, Jun Tang, Fen Yang, Gong-Kan Feng, Wen-Dan Chen, Xiao-Qi Wu, Xiao-Jun Qian, Shao-Hua Chang, Ke Ding, Xiao-Feng Zhu*. DC120, a novel AKT inhibitor, preferentially inhibits nasopharyngeal carcinoma cancer stem-like cells by downregulating Sox2 expression. Oncotarget. 2015; 6(9):6944-58   9. Yun-Tian Li, Xiao-Jun Qian, Yan Yu, Zhen-Hua Li, Rui-Yan Wu, Jiao Ji, Lin Jiao, Xuan Li, Peng-Fei Kong, Wen-Dan Chen, Gong-Kan Feng, Rong Deng, Xiao-Feng Zhu*. EGFR tyrosine kinase inhibitors promote pro-caspase-8 dimerization that sensitizes cancer cells to DNA-damaging therapy. Oncotarget. 2015 Apr 29. [Epub ahead of print]   10. Yang F, Deng R, Qian XJ, Chang SH, Wu XQ, Qin J, Feng GK, Ding K, Zhu XF*. Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer. Cell Death Dis. 2014;5:e1114.   11. He JH, Liao XL, Wang W, Li DD, Chen WD, Deng R, Yang D, Han ZP, Jiang JW, Zhu XF*. Apogossypolone, a small-molecule inhibitor of Bcl-2, induces radiosensitization of nasopharyngeal carcinoma cells by stimulating autophagy. Int J Oncol, 2014:45(3): 1099-108.   12. Yang F, Qian XJ, Qin W, Deng R, Wu XQ, Qin J, Feng GK, Zhu XF*. Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 has a therapeutic potential and sensitizes cisplatin in nasopharyngeal carcinoma. PLoS One. 2013;8(3):e59879   13. Xiao-Yue Zhang, Xiao-Qi Wu, Rong Deng, Ting Sun, Gong-Kan Feng, Xiao-Feng Zhu*. Upregulation of sestrin 2 expression via JNK pathway activation contributes to autophagy induction in cancer cells. Cell Signal. 2013 Jan;25(1):150-8   14. Rong Deng, Fen Yang, Shao-Hua Chang, Jun Tang, Juan Qin, Gong-Kan Feng, Ke Ding, Xiao-Feng Zhu*. DC120, a novel and potent inhibitor of AKT kinase, induces tumor cell apoptosis and suppresses tumor growth. Mol Pharmacol, 2012, 82(2):189-98   15. Jun Tang, Rong Deng, Rong-Zhen Luo, Guo-Ping Shen, Mo-Yan Cai, Zi-Ming Du, Shang Jiang, Ming-Tian Yang, Jian-Hua Fu, Xiao-Feng Zhu*. Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients. Breast Cancer Res Treat, 2012, 134(2):549-60   16. Dan-Dan Li, Ting Sun, Xiao-Qi Wu, Shu-Peng Chen, Rong Deng, Shan Jiang, Gong-Kan Feng, Jin-Xuan Pan, Xiao-shi Zhang, Yi-Xin Zeng, Xiao-Feng Zhu*. The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment. PLoS ONE*, 2012, 7(9): e45058. doi:10.1371/journal.pone.0045058   17. Fen Yang, Wen-Dan Chen, Rong Deng, Dan-Dan Li, Ke-Wei Wu, Gong-Kan Feng, Hou-Jin Li, Xiao-Feng Zhu*. Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells. J Pharmacol Sci, 2012, 119(3):214-20   18. Wei Qin, Zhen-Mei Lin, Deng R, Dan-Dan Li, Zhi Song, Yi-Guo Tian, RF Wang, JQ Ling, Xiao-Feng Zhu*. p38a MAPK is involved in BMP-2-induced odontoblastic differentiation of human dental pulp cells. Int Endod J, 2012,45(3):224-33   19. Ning-Ning Zhou, Jun Tang, Wen-Dan Chen, Gong-Kan Feng, Bin-Fen Xie, Zong-Chao Liu, Dajun Yang, Xiao-Feng Zhu*. Houttuyninum, an active constituent of Chinese herbal medicine, inhibits phosphorylation of HER2/neu receptor tyrosine kinase and the tumor growth of HER2/neu-overexpressing cancer cells. Life Sci, 2012, 22;90(19-20):770-5

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