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个人简介

现任生物治疗中心主任、医学博士、博士生导师,中华医学生物免疫学会主任委员,中国医药质量管理协会细胞治疗质量控制和研究专业委员会主任委员,广东省细胞生物学学会理事长,广东省抗癌协会生物治疗专业委员会主任委员,广东省免疫与生物治疗专业委员会主任委员,中国医药生物技术协会常务理事,中国生物治疗临床应用专业委员会常委,国家食品和药品监督管理局新药评审专家,国家华南肿瘤学重点实验室免疫与遗传研究课题组组长。美国《Cancer Letter》杂志编委,《癌症》杂志常务编委,国家自然基金和广东省自然基金重点项目评审专家。

研究领域

1、肿瘤的体细胞免疫治疗研究主要致力于体细胞免疫治疗的临床应用研究,包括肿瘤树突状细胞疫苗(DC疫苗),DC/肿瘤融合细胞疫苗、腺相关病毒介导肿瘤抗原转导的DC疫苗(DC-T细胞),细胞因子诱导的杀伤细胞(CIK细胞),DC刺激的CIK细胞(DC-CIK),自然杀伤细胞(NK细胞)和肿瘤浸润性淋巴细胞等。在肿瘤体细胞免疫治疗的临床应用过程中,为了保证临床安全和疗效,制定了体细胞制备流程和临床应用规范化准则,同时经过对大量接受体细胞免疫治疗患者疗效的观察和临床试验研究,建立了多种临床肿瘤体细胞免疫治疗的方案,在肿瘤体细胞免疫治疗的临床应用过程中,为提高体细胞免疫治疗在肿瘤临床中的疗效,经过大量的临床试验研究,在国内提出了肿瘤常规治疗联合体细胞免疫治疗的增效方案,为肿瘤患者在常规治疗(手术、化疗和放疗)后的巩固治疗提供了一种新的治疗手段。并在前期临床试用研究的基础上,率先提出要根据病人的肿瘤特征、遗传背景、病情状况、年龄等制定出适合病人的个体化体细胞免疫治疗策略,并建立了多种临床肿瘤体细胞免疫治疗的具体方案,为体细胞免疫治疗在临床肿瘤治疗中安全、有效的应用起到了关键性作用,真正实现了基础研究的成果向临床应用的快速转化。这些体细胞免疫治疗的具体方案包括:1、对年龄偏大的老年肿瘤患者采取少量抽血多次回输的方案,对抑制肿瘤的复发和转移取得了较好效果;2、率先提出在化疗或放疗间隙过程中联合体细胞免疫治疗的增效治疗方案,该治疗方案打破了长期以来认为化疗或放疗与体细胞免疫治疗不能联合使用的传统观点,为保护肿瘤患者免疫功能,提高疗效起到了积极的作用;3、率先提出了在肿瘤治疗过程中把不同的抗肿瘤免疫活性细胞交替使用的治疗方案,以防止一种抗肿瘤免疫效应细胞长期使用可能带来的免疫耐受,在临床上起到了较好的效果;4、率先提出把体细胞免疫治疗联合抗肿瘤的细胞因子、抗肿瘤抗体、生物分子靶向药物联合应用的增效治疗方案;5、率先提出在原发性肝癌手术或微创介入治疗后进行体细胞免疫治疗以抑制肿瘤复发和转移的个体化治疗模式,对有效抑制肝癌的复发和转移,提高原发性肝癌的疗效起到了较好的作用。目前,这些体细胞免疫治疗方案已在临床肿瘤治疗过程中得到广泛应用,为体细胞免疫治疗在临床肿瘤治疗过程中的规范化应用起到了重要作用,真正实现了基础研究的成果向临床应用的转化。基于上述开拓性的工作,极大的推动了肿瘤体细胞免疫治疗在临床肿瘤中的应用,目前中山大学附属肿瘤医院生物治疗中心已成为“华南生物治疗基地”挂靠单位,这个基地将为生物治疗的临床应用、新项目的研发、人才培养和国际合作提供良好的平台,为推动我国肿瘤体细胞免疫治疗在规范化应用的基础上健康有序的发展将发挥重要作用。2、肿瘤病因学的研究 主要致力于胃癌,肝癌和肾癌发病机制的研究,包括筛选与上述肿瘤密切相关的抑癌基因和癌基因,并进行相关功能的研究,同时结合临床,研究这些基因与临床疗效和预后之间的关系,为将来发展肿瘤新的有效治疗方法奠定实验基础。

近期论文

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5. Jiang SS, Weng DS, Wang QJ, Pan K, Zhang YJ, Li YQ, Li JJ, Zhao JJ, He J, Lv L, Pan QZ, Xia JC(Corresponding). Galectin-3 is associated with a poor prognosis in primary hepatocellular carcinoma. J Transl Med. 2014 Sep 27;12(1):273. 6. Chao J, Zhang XF, Pan QZ, Zhao JJ, Jiang SS, Wang Y, Zhang JH, Xia JC(Corresponding). Decreased expression of TRIM3 is associated with poor prognosis in patients with primary hepatocellular carcinoma. Med Oncol. 2014 Aug;31(8):102. 7. Mai C, Zhao JJ, Tang XF, Wang W, Pan K, Pan QZ, Zhang XF, Jiang SS, Zhao BW, Li YF, Xia JC(Corresponding), Zhou ZW. Decreased ITIH5 expression is associated with poor prognosisin primary gastric cancer. Med Oncol.2014 Jul;31(7);53. 8. Pan K, Wang QJ, Liu Q, Zheng HX, Li YQ, Weng DS, Li JJ, Huang LX, He J, Chen SP, Ke ML, Zeng YX, Xia JC(Corresponding). The phenotype of ex vivo generated cytokine-induced killer cells is associated with overall survival in patients with cancer. Tumour Biol 2014;35(1): 701-7. 9. Wang H, Jiang S, Zhang Y, Pan K, Xia JC(Corresponding), Chen M. High expression of thymosin beta 10 predicts poor prognosis for hepatocellular carcinoma after hepatectomy. World J Surg Oncol 2014 Jul 18;12:226. 10. Zhao JJ, Pan QZ, Pan K, Weng DS, Wang QJ, Li JJ, Lv L, Wang DD, Zheng HX, Jiang SS, Zhang XF, Xia JC (Corresponding). Interleukin-37 Mediates the Antitumor Activity in Hepatocellular Carcinoma: Role for CD57+ NK Cells. Sci Rep. 2014 Jun 5;4:5177. 11. Zheng Y, Wang DD, Wang W, Pan K, Huang CY, Li YF, Wang QJ, Yuan SQ, Jiang SS, Qiu HB, Chen YM, Zhang XF, Zhao BW, Mai C, Xia JC (Corresponding), Zhou ZW. Reduced expression of uroplakin 1A is associated with the poor prognosis of gastric adenocarcinoma patients. PLoS One. 2014 Apr 3;9(4):e93073. 12. Pan K, Guan XX, Li YQ, Zhao JJ, Li JJ, Qiu HJ, Weng DS, Wang QJ, Liu Q, Huang LX, He J, Chen SP, Ke ML, Zeng YX, Xia JC (Corresponding). Clinical activity of adjuvant cytokine-induced killer cell (CIK) immunotherapy in patients with post-mastectomy triple-negative breast cancer patients. Clin Cancer Res. 2014 Jun 1;20(11):3003-11. 13. Keshari RP, Wang W, Zhang Y, Wang DD, Li YF, Yuan SQ, Qiu HB, Huang CY, Chen YM, Xia JC (Corresponding), Zhou ZW. Decreased Expression of the GATA3 Gene Is Associated with Poor Prognosis in Primary Gastric Adenocarcinoma. PLoS One. 2014 Feb 4;9(2):e87195 14. Pan K, Lv L, Zheng HX, Zhao JJ, Pan QZ, Li JJ, Weng DS, Wang DD, Jiang SS, Chang AE, Li Q, Xia JC(Corresponding). OK-432 synergizes with IFN-γ to confer dendritic cells with enhanced antitumor immunity. Immunol Cell Biol. 2014 Mar;92(3):263-74. 15. Wang SH, Lu L, Fan Y, Wicha MS, Cao Z, Chang AE, Xia JC, Baker JR Jr, Li Q.Characterization of a novel transgenic mouse tumor model for targeting HER2+ cancer stem cells. Int J Biol Sci. 2013 Dec 6;10(1):25-32. 16. Pan QZ, Pan K, Weng DS, Zhao JJ, Zhang XF, Wang DD, Lv L, Jiang SS, Zheng HX, Xia JC(Corresponding). Annexin A3 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma. Mol Carcinog. 2013 Dec 23. 17. Yang XB, Zhao JJ, Huang CY, Wang QJ, Pan K, Wang DD, Pan QZ, Jiang SS, Lv L, Gao X, Chen HW, Yao JQ, Zhi M, Xia JC (Corresponding). Decreased Expression of the FOXO3a Gene Is Associated with Poor Prognosis in Primary Gastric Adenocarcinoma Patients. PLoS One. 2013 Oct 230;8(10): e78158 18. Pan QZ, Pan K, Zhao JJ, Chen JG, Li JJ, Lv L, Wang DD, Zheng HX, Jiang SS, Zhang XF, Xia JC (Corresponding). Decreased expression of interleukin-36α correlates with poor prognosis in hepatocellular carcinoma. Cancer Immunol Immunother. 2013 Sep 6. 19. Lu L, Pan K, Zheng HX, Li JJ, Qiu HJ, Zhao JJ, Weng DS, Pan QZ, Wang DD, Jiang SS, Chang AE, Li Q, Xia JC (Corresponding). IL-17A promotes immune cell recruitment in human esophageal cancers and the infiltrating dendritic cells represent a positive prognostic marker for patient survival. J Immunother. 2013 Oct;36(8):451-8. 20. Huang CY, Zhao JJ, Lv L, Chen YB, Li YF, Jiang SS, Wang W, Pan K, Zheng Y, Zhao BW, Wang DD, Chen YM, Yang L, Zhou ZW, Xia JC (Corresponding). Decreased Expression of AZGP1 Is Associated with Poor Prognosis in Primary Gastric Cancer. PLoS One. 2013 Jul 23;8(7):e69155. 21. Pan K, Li YQ, Wang W, Xu L, Zhang YJ, Zheng HX, Zhao JJ, Qiu HJ, Weng DS, Li JJ, Wang QJ, Huang LX, He J, Chen SP, Ke ML, Wu PH, Chen MS, Li SP, Xia JC (Corresponding), Zeng YX. The Efficacy of Cytokine-Induced Killer Cell Infusion as an Adjuvant Therapy for Postoperative Hepatocellular Carcinoma Patients. Ann Surg Oncol. 2013 Jul 27. 22. Huang ZM, Li W, Li S, Gao F, Zhou QM, Wu FM, He N, Pan CC, Xia JC, Wu PH, Zhao M. Cytokine-induced killer cells in combination with transcatheter arterial chemoembolization and radiofrequency ablation for hepatocellular carcinoma patients. J Immunother. 2013 Jun;36(5):287-93. 23. Zhang F, Sun XF, Li YQ, Zhen ZJ, Zheng HX, Zhu J, Wang QJ, Lu SY, He J, Wang J, Pan K, Cai RQ, Chen Y, Weng DS, Sun FF, Xia JC (Corresponding). Safety of in vitro amplified HLA-haploidentical donor immune cell infusions for childhood malignancies. Chin J Cancer. 2013 May 27. doi: 10.5732 / cjc.012.10298. 24. Zhao JJ, Pan K, Wang QJ, Xu ZD, Weng DS, Li JJ, Li YQ, Xia JC (Corresponding). Effect of anti-asthma Chinese medicine Chuankezhi on the anti-tumor activity of cytokine-induced killer cells. Chin J Cancer. 2013 Mar 8. doi: 10.5732/cjc.012.10249. 25. Huang CY, Chen YM, Zhao JJ, Chen YB, Jiang SS, Yan SM, Zhao BW, Pan K, Wang DD, Lv L, Li YF, Wang W, Zhou ZW, Xia JC (Corresponding). Decreased expression of transcription elongation factor a-like 7 is associated with gastric adenocarcinoma prognosis. PLoS One. 2013;8(1):e54671. 26. Li JJ, Shan HB, Xu GL, He LJ, Xia JC. Submucosal saline solution injection combined with endosonography for distinguishing between stages T1a and T1b of early esophageal cancer. Gastrointest Endosc. 2013 Jan;77(1):159-60. 27. Li JJ, Pan K, Gu MF, Chen MS, Zhao JJ, Wang H, Liang XT, Sun JC, Xia JC (Corresponding). Prognostic value of soluble MICA levels in the serum of patients with advanced hepatocellular carcinoma. Chin J Cancer. 2013 Mar;32(3):141-8. 28. Li YF, Wang DD, Zhao BW, Wang W, Huang CY, Chen YM, Zheng Y, Keshari RP, Xia JC (Corresponding), Zhou ZW. High Level of COP1 Expression is Associated with Poor Prognosis in Primary Gastric Cancer. Int J Biol Sci. 2012;8(8):1168-77. 29. Li YF, Wang DD, Zhao BW, Wang W, Yuan SQ, Huang CY, Chen YM, Zheng Y, Keshari RP, Xia JC (Corresponding), Zhou ZW. Poor prognosis of gastric adenocarcinoma with decreased expression of AHRR. PLoS One. 2012;7(8):e43555. 30. Wang DD, Chen YY, Pan K, Wang W, Chen SP, Chen JG, ZhaoJJ, Lv L, Pan QZ, Li YQ, Wang QJ, Huang LX, Ke ML, He J, Xia JC (Corresponding). Decreased Expression of the ARID1A Gene Is Associated with Poor Prognosis in Primary Gastric Cancer. PLoS One. 2012; 7(7): e40364 31. Zhao JJ, Pan K, Wang W, Chen JG, Wu YH, Lv L, Li JJ, Chen YB, Wang DD, Pan QZ, Li XD, Xia JC (Corresponding). The prognostic value of tumor-infiltrating neutrophils in gastric adenocarcinoma after resection. PLoS One. 2012;7(3):e33655. 32. Li JJ, Gu MF, Pan K, Liu LZ, Zhang H, Shen WX, Xia JC (Corresponding). Autologous Cytokine-Induced Killer Cell Transfusion in Combination with Gemcitabine plus Cisplatin Regimen Chemotherapy for Metastatic Nasopharyngeal Carcinoma. J Immunotherapy. 2012 Feb-Mar;35(2):189-95.

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