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个人简介

学习及工作经历: 1981年—1986年:南华大学医学院医疗系就读 1986年—1988年:南华大学附属第二医院外科工作 1988年—1991年:中山医科大学附属第一医院肝胆外科硕士生 1991年—1995年:广州市第一人民医院外科工作 1995年—1998年:中山医科大学附属第一医院胃肠胰外科博士生 1998年—2000年:中山大学附属肿瘤医院工作 2001年—2003年:美国Michigan大学癌症中心工作 2004年—至今:中山大学附属肿瘤医院工作 2009年—至今:中山大学附属肿瘤医院院长助理、副院长

研究领域

致力于肝胆胰肿瘤的临床和研究工作20余年,擅长胰腺、胆道、肝脏肿瘤的外科手术、局部消融、血管性介入及综合治疗,特别对于肝门部胆管癌根治及盆式胆肠重建术,胰十二指肠切除及门静脉系统重建术具有丰富的临床经验。近年,致力于微创外科新技术的开展,包括机器人辅助肿瘤切除、纳米刀局部消融。并牵头成立了胰腺癌多学科综合治疗MDT团队,是国内少有的能够同时完成肿瘤达芬奇机器人辅助根治术、开腹根治及联合血管切除及重建、纳米刀局部消融术等多种复杂术式及综合治疗的专家之一。

近期论文

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1.Wang J, Mao Y, Liu Y, Chen Z, Chen M, Lao X, Li S*. Hepatocellular Carcinoma in Children and Adolescents: Clinical Characteristics and Treatment. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. Apr 10 2017.(IF=2.8) 2.Mao Y, Xu S, Hu W, J. Huang, J. Wang, R. Zhang, S. Li*. Imaging features predict prognosis of patients with combined hepatocellular-cholangiocarcinoma. Clinical radiology. Feb 2017;72(2):129-135.(IF=2.1) 3.Chen JL, Lao XM, Lin XJ, Xu L, Cui BK, Wang J, Lin GH, Shuang ZY, Mao YZ, Huang X, Yun JP, Jin JT, Li SP*.Adjuvant Cytokine-Induced Killer Cell Therapy Improves Disease-Free and Overall Survival in Solitary and Nonmicrovascular Invasive Hepatocellular Carcinoma After Curative Resection. Medicine 2016; 95: 5(1-10). (IF:2.13) 4.Lin G, Liu Y, Li S, Mao Y, Wang J, Shuang Z, Chen J, Li S*. Elevated neutrophil-to-lymphocyte ratio is an independent poor prognostic factor in patients with intrahepatic cholangiocarcinoma. Oncotarget 2016;DOI: 10.18632/oncotarget.7680.(IF:5.0) 5.Chen, JL, Lin XJ, Zhou Q, Shi M, Li SP*, Lao XM*. Association of HBV DNA replication with antiviral treatment outcomes in the patients with early-stage HBV-related hepatocellular carcinoma undergoing curative resection. Chinese journal of cancer 2016; 35: 1, (28-41). (IF:2.81) 6.Xu L, Wang J, Kim Y, Shuang ZY, Zhang YJ, Lao XM, Li YQ, Chen MS, Pawlik T.M., Lau WY, Xia JC, Li SP*,Lau Wanyee. A randomized controlled trial on patients with or without adjuvant autologous cytokine-induced killer cells after curative resection for hepatocellular carcinoma. Oncoimmunology 2016;DOI/full/10.1080/2162402X.2015.1083671.(IF:7.64) 7.Zhang MY, Li SH, Huang GL, Lin GH, Shuang ZY, Lao XM, Xu L, Lin XJ, Wang HY* and Li SP*.Identification of a novel microRNA signature associated with intrahepatic cholangiocarcinoma (ICC) patient prognosis. BMC Cancer 2015 ;15:64 (1-8). (IF:3.3) 8.Shuang ZY, Wu WC, Xu J, Lin G, Liu YC, Lao XM, Zheng L, Li S* . Transforming growth factor-β1-induced epithelial-mesenchymal transition generates ALDH-positive cells with stem cell properties in cholangiocarcinoma. Cancer Lett 2014, 354:320-328.(IF:5.6) 9.Zhang PP, Wang XL, Zhao W, Qi B, Yang Q, Wan HY, Shuang ZY, Liu M, Li X, Li S*, Tang H. DNA Methylation-mediated Repression of miR-941 Enhances Lysine (K)-specific Demethylase 6B Expression in Hepatoma Cells. J Biol Chem 2014, 289: 24724-24735. (IF:4.5) 10.刘永成, 李书红, 双泽宇, 陈建霖, 李升平(通讯作者).术前外周血中性粒细胞/淋巴细胞比值对肝内胆管细胞癌术后预后的影响.中国普通外科杂志,2014,23(02):160-165. 11.Yan yan, Yue-Chen Luo, Hai-Ying Wan, Jun Wang, Pei-Pei Zhang, Min Liu, Xin Li, Shengping Li*, Hua Tang. MiR-10a is involved in metastatic process by regulating EphA4-mediated epithelial-mesenchymal transition and adhesion in hepatoma cells. Hepatology 2013, 57:667-677.(IF:11.0) 12.Liao Y, Wang B, Huang ZL, Shi M, Yu XJ, Zheng L, Li S*, Li L. Increased circulating Th17 cells after transarterial chemoembolization correlate with improved survival in stage III hepatocellular carcinoma: a prospective study. PLoS One 2013, 8:e60444 (1-9).(IF:3.2) 13.Lao XM, Luo G, Ye LT, Luo C, Shi M, Wang D, Guo R, Chen M, Li S*, Lin X, Yuan Y. Effects of antiviral therapy on hepatitis B virus reactivation and liver function after resection or chemoembolization for hepatocellular carcinoma. Liver Int 2013, 33:595-604.(IF:4.8) 14.Pan K, Li YQ, Wang W, Xu L, Zhang YJ, Zheng HX, Zhao JJ, Qiu HJ, Weng DS, Li JJ, Wang QJ, Huang LX, He J, Chen SP, Ke ML, Wu PH, Chen MS, Li SP*, Xia JC, Zeng YX. The efficacy of cytokine-induced killer cell infusion as an adjuvant therapy for postoperative hepatocellular carcinoma patients. Ann Surg Oncol 2013, 20:4305-4311.(IF:3.9) 15.Xu S, Wu Y, Chen Q, Cao J, Hu K, Tang J, Sang Y, Lai F, Wang L, Zhang R, Li SP, Zeng YX, Yin Y, Kang T. hSSB1 regulates both the stability and the transcriptional activity of p53. Cell Res 2013, 23:423-35. (IF:12.4) 16.Shengping Li, Ji Qian, Yuan Yang, Wanting Zhao,et al. GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. PLoS Genet 2012, 8:e1002791(1-9). (IF:7.5) 17.Lin G, Wang J, Lao X, Wang J, Li L, Li S, Zhang J, Dong Y, Chang AE, Li Q, Li S *. Interleukin-6 Inhibits Regulatory T Cells and Improves the Proliferation and Cytotoxic Activity of Cytokine-induced Killer Cells. J Immunother. 2012, 35:337-43.(IF.4.0)

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