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Shumin Ouyang, Huaxuan Li, Linlin Lou, Qiuyao Huang, Zhenhua Zhang, Jianshan Mo, Min Li, Jiaye Lu, Kai Zhu, Yunjie Chu, Wen Ding, Jianzheng Zhu, Ziyou Lin, Lin Zhong, Junjian Wang, Peibin Yue, James Turkson, Peiqing Liu*, Yuanxiang Wang*, Xiaolei Zhang*. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biology. 2022, (52) 102317 (中科院一区， IF=10.79 )
Yang Ge, Jun-Jie Deng, Jianzheng Zhu, Lu Liu, Shumin Ouyang, Zhendong Song, Xiaolei Zhang*, Xiao-Feng Xiong*, Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma, Acta Pharmaceutica Sinica B, 2022, Aug;12(8):3326-3340 (中科院一区，IF=14.90 )
Lin Deng, Jianshan Mo, Yi Zhang, Keren Peng, Huaxuan Li, Shumin Ouyang, Zongbo Feng, Wei Fang, Jianwei Wei, Deqin Rong, Xiaolei Zhang*, Yuanxiang Wang*. Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3. J Med Chem. 2022 Oct 13;65(19):13094-13111(中科院一区，IF=8.04 )
Shuhao Liu, Shuhao Liu, Wen Ding, Weifeng Huang, Zhijing Zhang, Yinfeng Guo, Qiyi Zhang, Linna Wu, Yukai Li, Rui Qin, Jiahao Li, Taoda Shi*, Xiaolei Zhang*, Jinping Lei*, and Wenhao Hu*. Discovery of Novel Benzo[4,5]imidazo[1,2-a]pyrazin-1-amine-3-amide-one Derivatives as Anticancer Human A2A Adenosine Receptor Antagonists. J. Med. Chem. 2022, Jul 14;65(13):8933-8947 (中科院一区，IF=8.04 )
Huaxuan Li , Shumin Ouyang , Yi Zhang , Keren Peng , Wei Fang, Zhiqing Liu, Chang-Yun Wang , Xiaolei Zhang*, Yuanxiang Wang*. Structural optimization of Imidazo[1, 2-a]pyridine derivatives for the treatment of gastric cancer via STAT3 signaling pathway. Eur J Med Chem. 2022, 244,114858 (中科院一区， IF=7.09 )
Zhendong Song, Linlin Lou, Guangjin Fan, Lu Liu, Yang Ge, He Liu, Albert S.C. Chan, Xiaolei Zhang*, Xiaofeng Xiong*. Identification of Novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C Inhibitors with Anticancer Effects. Eur J Med Chem. 2022, Nov 9th, doi.org/10.1016/ j.ejmech.2022.114907 (中科院一区， IF=7.09 )
Shumin Ouyang, Qiyi Zhang, Linlin Lou, Kai Zhu, Zeyu Li, Peiqin Liu*, Xiaolei Zhang*. The double-edged sword of SIRT3 in cancer and its therapeutic applications. Frontiers in Pharmacology, 2022, April 27th, (13):871560 ( 中科院二区，IF=5.99 )
张芷菁, 张启怡, 金祖翼, 朱凯, 丁文*, 张小雷*. 靶向腺苷A2A受体的肿瘤免疫治疗研究进展(Progress for targeting adenosine A2A receptors in cancer immunotherapy), 药学学报 Acta Pharmaceutica Sinica, 2022, 57(9):2557−2569
Huanxin Xue, Jiaye Lu, Hongwei Yan, Ju Huang, Hai-Bin Luo, Man Shing Wong, Yuqi Gao*, Xiaolei Zhang*, Lei Guo*. γ-Glutamyl transpeptidase–activated indole-quinolinium based cyanine as a fluorescence turn-on nucleolus-targeting probe for cancer cell detection and inhibition. Talanta，2022 Jan 15;237:122898 (中科院二区， IF=6.56 )
Guangjin Fan, Linlin Lou, Zhendong Song*, Xiaolei Zhang*, Xiao-Feng Xiong*. Targeting mutated GTPase KRAS in tumor therapies. Eur J Med Chem. 2021; 226:113816 (中科院一区， IF=7.09 )
Ziyou Lin; Arabella H Wan; Lei Sun; Heng Liang; Yi Niu; Yuan Deng; Shijia Yan; Qiao-Ping Wang; Xianzhang Bu; Xiaolei Zhang; Kunhua Hu*; Guohui Wan*; Weiling He*. N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis. Molecular Therapy, 2022 Oct 28;S1525-0016(22)00624-4 (中科院一区， IF=12.91 )
Jing, Tongfei; Zhang, Zhijing ; Kang, Zhenghui; Yue, Xiaotong; Lin, Ziyou; Fu, Xiang; Liu, Chang; Ma, Hang; Zhang, Xiaolei*; Hu, Wenhao*. Discovery and Optimization of Novel Biphenyl Derivatives Bearing Cyclopropyl Linkage as Potent Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Inhibitors. J Med Chem. 2022 in revision
Yan Zhong, Lin Deng, Shuo Shi, Qiu-yao Huang, Shu-min Ou-Yang, Jian-shan Mo, Kai Zhu, Xin-ming Qu, Pei-qing Liu*, Yuan-xiang Wang* and Xiao-lei Zhang*.The novel STAT3 inhibitor WZ-2-033 causes regression of human triple-negative breast cancer and gastric cancer xenografts. Acta Pharmacol Sin. 2022 Apr;43(4):1013-1023 (中科院一区， IF=7.19)
Qiuyao Huang, Yan Zhong, Bingbing Li, Shumin Ouyang, Lin Deng, Jianshan Mo, Shuo Shi, Nan Lv, Ruibo Wu, Peiqing Liu, Wenhao Hu, Xiaolei Zhang* Yuanxiang Wang*. Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3). Eur J Med Chem. 2021;221:113525. (中科院一区， IF=7.09 )
Zheng Q, Dong H, Mo J, Zhang Y, Huang J, Ouyang S, Shi S, Zhu K, Qu X, Hu W, Liu P*, Wang Y*, Zhang X*. A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance. Theranostics. 2021; 11(2):824-840. (中科院一区， IF=11.60 )
Yang Ge, Shuo Shi, Jun-Jie Deng, Xue-Ping Chen, Zhendong Song, Lu Liu, Linlin Lou, Xiaolei Zhang*, Xiao-Feng Xiong*.Design, Synthesis, and Evaluation of Small Molecule Gαq/11 Protein Inhibitors for the Treatment of Uveal Melanoma. J Med Chem. 2021,64(6):3131-3152. (中科院一区， IF=8.04 )
Xiao-lei Zhang#, Zhuo-ming Li#, Jian-tao Ye, Jing Lu, Lingyu Linda Ye, Chun-xiang Zhang, Pei-qing Liu* and Dayue D Duan*. Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives. Acta Pharmacol Sin. 2020 Nov; 41(11): 1377–1386. (中科院一区， IF=7.19 )
Qiuyao Huang, Yan Zhong, Hui Dong, Qiyao Zheng, Shuo Shi, Kai Zhu, Xinming, Wenhao Hu, Xiaolei Zhang*, Yuanxiang Wang*. Revisiting signal transducer and activator of transcription 3 (STAT3) as an anticancer target and its inhibitor discovery: Where are we and where should we go? Eur J Med Chem. 2020 ;187: 111922. (中科院一区， IF=7.09 )
Jingyan Li , Junying Huang, Jing Lu, Zhen Guo, Zhuoming Li, Hui Gao, Panxia Wang, Wenwei Luo, Sidong Cai, Yuehuai Hu, Kaiteng Guo, Luping Wang, Zhenzhen Li, Minghui Wang, Xiaolei Zhang*, Peiqing Liu*. Sirtuin 1 represses PKC-ζ activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy, British Journal of Pharmacology, 2019, 176(3):416-435 (中科院药学一区， IF=9.47 )
Jian Li, Yang Ge, Junxiang Huang, Kristan Stromgaard, Xiaolei Zhang, Xiaofeng Xiong*. Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery. J Med Chem. 2020 May 28;63(10):5013-5030 (中科院一区，IF=8.04 )
石硕、朱凯、熊晓峰*、张小雷*。Gq 突变在葡萄膜黑色素瘤中的作用及其抑制剂研究进展 （Study of Gq mutations and their inhibitors in uveal melanoma）。药学学报 Acta Pharmaceutica Sinica 2020, 55(7): 1382 −1392
Jing Lu, Suowen Xu, Yuqing Huo, Duanping Sun, Yuehuai Hu, Junjian Wang, Xiaolei Zhang, Panxia Wang, Zhuoming Li, Mengya Liang, Zhongkai Wu*, Peiqing Liu*. Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3. Cell death and differentiation. 2021 Oct;28(10):2871-2887 (中科院一区， IF=15.83 )
Jianwei Zheng, Junfeng Wang, Qian Wang, Hongye Zou, Hong Wang, Zhenhua Zhang, Jianghe Chen, Qianqian Wang, Panxia Wang, Yueshan Zhao, Jing Lu, Xaiolei Zhang, Songtao Xiang, Haibin Wang, Jinping Lei, Hong-Wu Chen, Peiqing Liu, Yonghong Liu*, Fanghai Han*, Junjian Wang*. 2020 Targeting castration-resistant prostate cancer with a novel RORγ antagonist elaiophylin, Acta Pharmaceutica Sinica B, 2020,10(12), 2313-2322 (中科院一区， IF=14.90 )
Lin Z, Niu Y, Wan A, Chen D, Liang H, Chen X, Sun L, Zhan S, Chen L, Cheng C, Zhang X, Bu X, He W*, Wan G*. RNA m6 A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy. The EMBO Journal. 2020 Jun 17;39(12):e103181. (中科院一区， IF=14.01 )
Yuting Zhang, Weiting Lu, Xiaolei Zhang, Jing Lu, Suowen Xu, Shaorui Chen, Zhi Zhong, Ting Zhou, Quan Wang, Jianwen Chen*, Peiqing Liu*. Cryptotanshinone protects against pulmonary fibrosis through inhibiting Smad and STAT3 signaling pathways. Pharmacol Res. 2019 Sep;147:104307 ( IF=10.33 )
Michelle B. Trevino#, Xiaolei Zhang#, Robert A. Standley, Miao Wang,Xianlin Han, Felipe C. G. Reis, Muthu Periasamy, Gongxin Yu, Daniel P. Kelly, Bret H. Goodpaster,Rick B. Vega,1,2 and Paul M. Coen*.Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy. Am J Physiol Endocrinol Metab. 2019 Nov 1; 317(5): E899–E910.
Xiaolei Zhang, Trevino MB, Wang M, Gardell SJ, Ayala JE, Han X, Kelly DP, Goodpaster BH, Vega RB, Coen PM. Impaired Mitochondrial Energetics Characterize Poor Early Recovery of Muscle Mass Following Hind Limb Unloading in Old Mice, J Gerontol A Biol Sci Med Sci. 2018,73(10):1313-1322 (中科院一区， IF=6.59)
Stephen J Gardell, Xiaolei Zhang, Nidhi Kapoor, Christopher Petucci, Paul M Coen. Metabolomics Analyses of Muscle Atrophy Induced by Hind Limb Unloading. Methods Mol Biol. 2019;1996:297-309
Giovanna Distefano, Robert A. Standley, Xiaolei Zhang, Elvis A. Carnero, Fanchao Yi, Heather H. Cornnell, Paul M. Coen*. Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. J Cachexia Sarcopenia Muscle. 2018 Apr; 9(2): 279–294. (中科院一区， IF=12.06 )
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