袁燕秋 - 中山大学

个人简介

教育经历 2008年，理学博士，化学与化学生物学系，美国哈佛大学，论文导师: Suzanne Walker 2003年，理学学士，应用化学系, 中国科学技术大学工作经历 2017年9月 - 至今中山大学副教授 2015年1月 - 2017年8月丹麦哥本哈根大学助理教授 2011年8月 - 2014年12月美国诺华生物医学研究所（NIBR）二级研究员（Investigator II） 2008年8月 - 2011年7月美国诺华生物医学研究所（NIBR）一级研究员（Investigator I）

研究领域

目前研究聚焦于蛋白质翻译后修饰相关的药物靶标发现、药物筛选，以及相关化学生物学、药理学研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Chen X, Giraldes J, Sprague ER, Shakya S, Chen Z, Wang Y, Joud C, Mathieu S, Chen CH, Straub C, Duca J, Hurov K, Yuan Y, Shao W, Touré BB. "Addition" and "Subtraction": Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors. J. Med. Chem., 2017, 60, 2155-2161. 2.Touré BB, Giraldes J, Smith T, Sprague ER, Wang Y, Mathieu S, Chen Z, Mishina Y, Feng Y, Yan-Neale Y, Shakya S, Chen D, Meyer M, Puleo D, Brazell JT, Straub C, Sage D, Wright K, Yuan Y, Chen X, Duca J, Kim S, Tian L, Martin E, Hurov K, Shao W. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J. Med. Chem., 2016, 59, 4711-23. 3.Six DA, Yuan Y, Leeds JA, Meredith TC. Deletion of the β-Acetoacetyl Synthase FabY in Pseudomonas aeruginosa Induces Hypoacylation of Lipopolysaccharide and Increases Antimicrobial Susceptibility. Antimicrob. Agents Chemother., 2014, 58, 153-161. 4.Yuan Y, Sachdeva M, Leeds JA, Meredith TC. Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the FabY class of β-ketoacyl acyl carrier protein synthases. J. Bacteriol., 2012, 194, 5171-5184. 5.Yuan Y, Leeds JA, Meredith TC. Pseudomonas aeruginosa directly shunts β-oxidation degradation intermediates into de novo fatty acid biosynthesis. J. Bacteriol., 2012, 194, 5185-5196. 6.Fuse S, Tsukamoto H, Yuan Y, Wang TS, Zhang Y, Bolla M, Walker S, Sliz P, Kahne D. Functional and structural analysis of a key region of the cell wall inhibitor moenomycin. ACS Chemical Biology, 2010, 5, 701-11. 7.Yuan Y, Fuse S, Sliz P, Kahne D, Walker S. Structural and functional analysis of the H-bonding network that anchors moenomycin in the peptidoglycan glycosyltransferase active site: implications for antibiotic design. ACS Chemical Biology, 2008, 3, 429-436. 8.Barrett D, Wang TS, Yuan Y, Zhang Y, Kahne D, Walker S. Analysis of glycan polymers produced by peptidoglycan glycosyltransferases. J. Biol. Chem.,2007, 208, 31964-31971. 9.Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, Walker S. Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proc. Natl. Acad. Sci. U. S. A., 2007, 104, 5348-5453. 10. Ginsberg C, Zhang YH, Yuan Y, Walker S. In vitro reconstitution of two essential steps in wall teichoic acid biosynthesis. ACS Chem. Biol., 2006, 1, 25-28. 11. Zhang YH, Ginsberg C, Yuan Y, Walker S. Substrate selectivity and kinetic mechanism of Bacillus subtilis TagA. Biochemistry, 2006, 45, 10895-10904. 12. Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S. In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides. J. Am. Chem. Soc., 2005, 127, 14128-14129. 13. Chen L, Yuan Y, Helm JS, Hu Y, Rew Y, Shin D, Boger DL, Walker S. Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics. J. Am. Chem. Soc., 2004, 126, 7462-7463.