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1）Xie, H.-T.; Zhou, D.-C.; Mai, Y.-W.; Huo, L.; Yao, P.-F.; Huang, S.-L.*; Wang, H.-G.; Huang, Z.-S.; Gu, L.-Q. Construction of the oxaphenalene skeletons of mansonone F derivatives through C–H bond functionalization and their evaluation for anti-proliferative activities. RSC Adv. 2017, 7, 20919-20928. 2）Li, P. H.; Zeng, P.; Chen, S. B.; Yao, P. F.; Mai, Y. W.; Tan, J. H.; Ou, T. M.; Huang, S. L.*; Li, D.; Gu, L. Q.; Huang, Z. S.*Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors. J Med. Chem. 2016, 59, 238-52. 3）Zhai, P.; Xia, C. L.; Tan, J. H.; Li, D.; Ou, T. M.; Huang, S. L.*; Gu, L. Q.; Huang, Z. S.* Syntheses and evaluation of asymmetric curcumin analogues as potential multifunctional agents for the treatment of Alzheimer's disease. Current Alzheimer research 2015, 12, 403-14. 4） Yao, B. L.; Mai, Y. W.; Chen, S. B.; Xie, H. T.; Yao, P. F.; Ou, T. M.; Tan, J. H.; Wang, H. G.; Li, D.; Huang, S. L.*; Gu, L. Q.; Huang, Z. S.* Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors. Eur. J. Med. Chem. 2015, 92, 540-53. 5）Zhuo, S. T., Li, C. Y., Hu, M. H., Chen, S. B., Yao, P. F., Huang, S. L.,* Ou, T. M., Tan, J. H., An, L. K., Li, D., Gu, L. Q., and Huang, Z. S.* Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II, Org. Biomol. Chem. 2013,11(24), 3989-4005. 2) Huang, Z. H., Zhuo, S. T., Li, C. Y., Xie, H. T., Li, D., Tan, J. H., Ou, T. M., Huang, Z. S., Gu, L. Q., and Huang, S. L.* Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors, Eur. J. Med. Chem. 2013,68C, 58-71. 3) Chen, Y. P., Zhang, Z. Y., Li, Y. P., Li, D., Huang, S. L.,* Gu, L. Q., Xu, J., and Huang, Z. S. () Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase, Eur. J. Med. Chem. 2013, 66, 22-31. 4) Li, Y. P., Weng, X., Ning, F. X., Ou, J. B., Hou, J. Q., Luo, H. B.,* Li, D., Huang, Z. S., Huang, S. L.,* and Gu, L. Q. 3D-QSAR studies of azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives as anti-AChE and anti-AD agents by the CoMFA method, J. Mol. Graph. Model. 2013, 41, 61-67. 5) Li, Y.-P., Ning, F.-X., Yang, M.-B., Li, Y.-C., Nie, M.-H., Ou, T.-M., Tan, J.-H., Huang, S.-L.,* Li, D., Gu, L.-Q., Huang, Z.-S. Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation. Eur. J. Med. Chem., 2011. 46(5): 1572-1581 6) Fang Xian Ning, Xiang Weng, Shi Liang Huang,* Li Jun Gu, Zhi Shu Huang, * Lian Quan Gu.A facile and efficient method for hydroxylation of azabenzanthrone compounds.Chin. Chem. Lett. 2011,22(1), 41-44 7) Wei-bin Wu, Jie-bin Ou, Zhi-shu Huang, Shuo-bin Chen, Tian-miao Ou, Jia-heng. Tan, Ding Li, Liu-lan. Shen, Shi-liang Huang*, Lian-quan Gu and Zhi-shu Huang, Eur. J. Med. Chem. 2011, 46, 3339-3347. 8) Zhong Liu, Shi-Liang Huang, Man-Mei Li, Zhi-Shu Huang, Kin Sing Lee*, Lian-Quan Gu*. Inhibition of thioredoxin reductase by mansonone F analogues: Implications for anticancer activity. Chem-Bio. Interac. 2009, 177(1), 48-57 9) Hua-pei Jian, Xing-yuan Wang, Zhi-shu Huang, Shi-liang Huang,*, Lian-quan Gu. A Facile Synthesis of Novel Heteropolycyclic Pyrazines and Oxazoles Mechanistic Studies of 2,3-Dihydrobenzo[de]chromene-7,8-dione with Amines. Heterocycles. 2008,75(7),1773-1778. 10) Shi-Liang Huang, Yi Luo, Zhi-Shu Huang, Xing-Yuan Wang, Xian-Zhang Bu, Pei-Qing Liu, Lin Ma, Bing-Fen Xie, Zong-Chao Liu, Yue-Ming Li, Albert S. C. Chand, Lian-Quan Gu. Synthesis and Cytotoxicity of 9-Substitued benzo[de] chromene -7,8-dione and 5-benzyl -9- Substitued benzo[de]chromene-7,8-dione. Synthetic Communications. 2006, 36(18), 2667-2684. 11) Shi Liang Huang, Yi Luo, Zhi Shu Huang, Xian Zhang Bu, Pei Qing Liu, Lin Ma, Yue Ming Li, Albert S. C. Chan, Lian Quan Gu. The Mechanism on Cyclization, Debenzylation and Oxidation of 1-[1- (Benzyloxy)-3- methylnaphthalen-4- yloxy]propan-2-one. Chin. Chem. Lett.2006, 17(6), 769-772.