李清江 - 中山大学

个人简介

教育经历 2003年9月至2007年6月，兰州大学化学化工学院，学士 2007年9月至2012年7月，北京大学，博士，导师：贾彦兴教授、崔育新教授工作经历 2013年1月至2014年11月，香港中文大学，博士后，合作导师：黄乃正院士 2014年11月至今，中山大学药学院，副教授

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Li, Q.;* Liu, X.-B.; Wang, H.* Iodine(III)-Mediated Migratory gem-Difluorinations: Synthesis of β Transformable Functionality Substituted gem-Difluoroalkanes. Chem. Rec. 2023, e202300231. Qian, J.; Liu, L.-C.; Chen, Z.-H.; Liu, Y.; Li, Y.; Li, Q.;* Wang, H.* Sigmatropic rearrangements of B(MIDA)-propargylic alcohols towards the diverse synthesis of α-functionalized organoborons. Sci. China Chem. 2023, 66, DOI: 10.1007/s11426-023-1722-8. Yang, S.; Wu, J.-Y.; Lin, S.; Pu, M.; Huang, Z.-S.; Wang, H.;* Li, Q.* Divergent Fluorinations of Vinylcyclopropanes: Ring-Opening 1,5-Hydrofluorination and Ring-Retaining 1,2-Difluorination. Chem. Asian J. 2023, e202300476. Liu, L.-C., Qian J.; Duan, L.; Wang, B.; Tu, F.-H.; Li, Q.;* Wang, H.* Stereoselective Synthesis of Amphoteric α-Haloalkenyl Boronates by Halogenative Semipinacol Rearrangement of B(MIDA)-Propargylic Alcohols. Chem. Eur. J. 2023, e202301011. Xue, J.-H.; Li, Y.; Tan, D.-H.; Tu, F.-H.; Liu, Y.; Li, Q.;* Wang, H.* Deaminative Bromination, Chlorination and Iodination of Primary Amines. iScience. 2023, 26, 106255. Yang, S.; Liu, X.-B.; Feng, S.-X.; Li, Y.; Tu, F.-H.; Huang, B.; Huang, L.-L.; Huang, Z.-S.; Wang, H.; Li, Q.* Hypervalent Iodine(III)-Mediated Ring-expansive Difluorination of Alkynylcyclopropanes en route to the Synthesis of Difluorinated Alkylidenecyclobutanes. Org. Chem. Front. 2022, 9, 4447-4452. Huang, L.-L.; Lin, P.-P.; Li, Y.-X.; Feng, S.-X.; Tu, F.-H.; Yang, S.; Zhao, G.-Y.; Huang, Z.-S.; Wang, H.; Li, Q.* Oxidative Fluoroarylation of Benzylidenecyclopropanes with HF·Py and Aryl Iodides via Iodonio-[3,3]-Rearrangement. Org. Lett. 2022, 24, 3389-3394. Zhang, Y.; Yang, H.; Wang, F.-T.; Peng, X.; Liu, H.-Y.; Li, Q.-J.;* An, L.-K.* Discovery, Enantioselective Synthesis of Myrtucommulone E Analogues as Tyrosyl-DNA Phosphodiesterase 2 Inhibitors and Their Biological Activities. Eur. J. Med. Chem. 2022, 238, 114445. Jiang, Z.; Zhao, D.-D.; Hu, Y.-T.; Rao, Y.; Guo, S.-Y.; Xu, Y.-H.; Li, Q.;* Huang, Z.-S.* Palladium Oxidative Addition Complex-enabled Synthesis of Amino-substituted Indolyl-4(3H)-quinazolinones and Their Antitumor Activity Evaluation. Org. Biomol. Chem. 2022, 20, 553-557. Feng, S.-X.; Yang, S.; Tu, F.-H.; Lin, P.-P.; Huang, L.-L.; Wang, H.; Huang, Z.-S.; Li, Q.* Iodine(III)-Mediated Fluorination/Semipinacol Rearrangement Cascade of 2-Alkylidenecyclobutanol Derivatives: Access to β-Monofluorinated Cyclopropanecarbaldehydes. J. Org. Chem. 2021, 86, 6800-6812. Lin, P.-P.; Huang, L.-L.; Feng, S.-X.; Yang, S.; Wang, H.; Huang, Z.-S.; Li, Q.* gem-Difluorination of Methylenecyclopropanes (MCPs) Featuring a Wagner–Meerwein Rearrangement: Synthesis of 2-Arylsubstituted gem-Difluorocyclobutanes. Org. Lett. 2021, 23, 3088-3093. Zhang, Q.-Q.; Lin, P.-P.; Yang, L.; Tan, D.-H.; Feng, S.-X.; Wang, H.; Li, Q.* Visible-Light-Promoted Ir(III)-Catalyzed Z→E Isomerization of Monofluorostilbenes. Chin. J. Org. Chem. 2020, 40, 3314-3326. Ni, F.-Q.; Wu, S.-Q.; Li, W.; Li, Q.;* Yin, S.* Stereoselective Construction of the Methylcyclopentane Core of Peditithins B−H with Five Continuous Stereocenters. Org. Lett. 2020, 22, 9360-9364. Lin, P.-P.;† Han, X.-L.;† Ye, G.-H.; Li, J.-L.; Li, Q.;* Wang, H.* Cp*Co(III)-Catalyzed Dearomative [3 + 2] Spiroannulation of 2‑Alkenylphenols with Ynamides via C−H Activation. J. Org. Chem. 2019, 84, 12966-12974. (†co-first author) Han, X.-L.; Lin, P.-P.; Li, Q.* Recent advances of allenes in the first-row transition metals catalyzed C-H activation reactions. Chin. Chem. Lett. 2019, 30, 1495-1502. Zhang, Q.-Q.; Chen, S.-Y.; Lin, E.; Wang, H.; Li, Q.* Regio- and Stereoselective Alkenylation of Allenoates with gem-Difluoroalkenes: Facile Access to Fluorinated 1,4-Enynes Bearing an All-Carbon Quaternary Center. Org. Lett. 2019, 21, 3123-3126. Li, J.-L.; Lin, E.; Han, X.-L.; Li, Q.;* Wang, H.* Synthesis of α-Fluorinated Imides via Direct Fluorohydroxylation of Ynamides. Org. Lett. 2019, 21, 4255-4258. Lv, W.-X.;† Li, Q.;† Li, J.-L.; Li, Z.; Lin, E.; Tan, D.-H.; Cai, Y.-H.; Fan, W.-X.; Wang, H.* gem-Difluorination of Alkenyl MIDA Boronates: Synthesis of α- and β-Difluorinated Alkylborons. Angew. Chem. Int. Ed. 2018, 57, 16544-16548. (†co-first author) Han, X.-L.; Liu, X.-G.; Lin, E.; Chen, Y.; Chen, Z.; Wang, H.; Li, Q.* Cp*Co(III)-Catalyzed Oxidative [5+2] Annulation: Regioselective Synthesis of 2-Aminobenzoxepines via C-H/O-H Functionalization of 2-Vinylphenols with Ynamides. Chem. Commun. 2018, 54, 11562-11565. Han, X.-L.; Zhou, C.-J.; Liu, X.-G.; Zhang, S.-S.; Wang, H.; Li, Q.* Regioselective Synthesis of 5‑Aminooxazoles via Cp*Co(III)-Catalyzed Formal [3 + 2] Cycloaddition of N‑(Pivaloyloxy)amides with Ynamides. Org. Lett. 2017, 19, 6108-6111. Chen, S.-Y.; Li, Q.;* Wang, H.* Mn(I)-Catalyzed Direct C-H Allylation of Arenes with Allenes. J. Org. Chem. 2017, 82, 11173-11181. Chen, S.-Y.; Han, X.-L.; Li, Q.;* Chen, Y.; Wang, H.* Mn(I)-Catalyzed Regio- and Stereoselective 1,2-Diheteroarylation of Allenes: Combination of C-H Activation and Smiles Rearrangement. Angew. Chem. Int. Ed. 2017, 56, 9939-9943. (Highlighted in Chin. J. Org. Chem. 2017, 37, 2783-2784.) Chen, S.-Y.; Li, Q.;* Liu, X.-G.; Wu, J.-Q.; Zhang, S.-S.; Wang, H.* Polycyclization Enabled by Relay Catalysis: One-Pot Manganese-Catalyzed C-H Allylation and Silver-Catalyzed Povarov Reaction. ChemSusChem 2017, 10, 2360-2364. Liu, Y.; Zhou, C.-J.; Li, Q.;* Wang, H.* Total Synthesis of (±)-Ganocins B and C. Org. Biomol. Chem. 2016, 14, 10362-10365. Zhang, S.-S.; Liu, X.-G.; Chen, S.-Y.; Tan, D.-H.; Jiang, C.-Y.; Wu, J.-Q.; Li, Q.;* Wang, H.* (Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Oxidative [4+2] Annulation of N‑H Imines with Alkynes: Straightforward Synthesis of Multisubstituted Isoquinolines. Adv. Synth. Catal. 2016, 358, 1705 –1710. Lv, W.-X.; Zeng, Y.-F.; Zhang, S.-S.; Li, Q.;* Wang, H.* Mild Mn(OAc)3‑Mediated Aerobic Oxidative Decarboxylative Coupling of Arylboronic Acids and Arylpropiolic Acids: Direct Access to Diaryl 1,2-Diketones. Org. Lett. 2015, 17, 2972-2975. Li, Q.; Peng, X.-S.; Wong, H. N.C.* Brønsted Acid-catalyzed Synthesis of Carbazoles from 2-Substituted Indoles. Org. Chem. Front. 2014, 1, 1197-1200. Liu, Q.;† Li, Q.;† Ma, Y.; Jia, Y.* Direct Olefination at the C-4 Position of Tryptophan via C-H Activation: Application to Biomimetic Synthesis of Clavicipitic Acid. Org. Lett. 2013, 15, 4528-4531. (†co-first author) Li, Q.; Mao, S.; Cui, Y.; Jia, Y.* Stereoselective Synthesis of the C5-C18 Fragment of Halichomycin. J. Org. Chem. 2012, 77, 4111-4116. Li, Q.; Jiang, J.; Fan, A.; Cui, Y.; Jia, Y.* Total Synthesis of Lamellarins D, H, and R and Ningalin B. Org. Lett. 2011, 13, 312-315. Li, Q.; Fan, A.; Lu, Z.; Cui, Y.; Lin, W.; Jia, Y.* One-Pot AgOAc-Mediated Synthesis of Polysubstituted Pyrroles from Primary Amines and Aldehydes: Application to the Total Synthesis of Purpurone. Org. Lett. 2010, 12, 4066-4069.