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个人简介

邹滔滔,博士,中山大学教授、博士生导师,国家优秀青年基金获得者(2021年),广东省“珠江人才计划”青年拔尖人才(2019)。2010年毕业于武汉大学化学学院(导师:杨楚罗教授),2015年2月毕业于香港大学化学系(导师:支志明院士),其后三年时间,分别在斯科利普斯研究所(导师:Xiang-Lei Yang教授、Paul Schimmel教授)、香港大学(导师:支志明教授)、华威大学(导师Peter J Sadler教授)从事博士后研究工作

研究领域

研究方向为药物化学生物学和生物无机化学,长期致力于开发含金属药物,近期研究方向集中在设计新型抗癌前体药物和发展具有抗癌免疫活性的小分子药物等领域

近期论文

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Luo, Y.; Cao, B.; Zhong, M.; Liu, M.; Xiong, X.; Zou, T.*, Organogold(III) Complexes Display Conditional Photoactivities: Evolving From Photodynamic into Photoactivated Chemotherapy in Response to O2 Consumption for Robust Cancer Therapy. Angew. Chem. Int. Ed. 2022, e202212689. Xiong, X.†; Huang, K.-B.†; Wang, Y.†; Cao, B.; Luo, Y.; Chen, H.; Yang, Y.; Long, Y.; Liu, M.; Chan, A. S. C.; Liang, H.*; Zou, T.*, Target Profiling of an Iridium(III)-based Immunogenic Cell Death Inducer Unveils the Engagement of Unfolded Protein Response Regulator BiP. J. Am. Chem. Soc., 2022, 144, 10407-10416.. Jiang, J.†; Cao, B.†; Chen, Y.†; Luo, H.; Xue, J.; Xiong, X.; Zou, T.*, Alkylgold(III) Complexes Undergo Unprecedented Photo-Induced β-Hydride Elimination and Reduction for Targeted Cancer Therapy. Angew. Chem. Int. Ed. 2022, 61, e202201103. Xiong, X.; Liu, L.-Y.; Mao, Z.-W.*; Zou, T.* Approaches towards understanding the mechanism-of-action of metallodrugs. Coord. Chem. Rev. 2022, 453, 214311. Long, Y.†; Cao, B.†; Xiong, X.; Chan, A. S. C.; Sun, R. W.-Y.; Zou, T.*, Bioorthogonal Activation of Dual Catalytic and Anti-Cancer Activities of Organogold(I) Complexes in Living Systems. Angew. Chem. Int. Ed. 2021, 60, 4133-4141. (Hot Paper) Luo, H.; Cao, B.; Chan, A. S. C.; Sun, R. W.-Y.; Zou, T.*, Cyclometalated Gold(III)-Hydride Complexes Exhibit Visible Light-Induced Thiol Reactivity and Act as Potent Photo-Activated Anti-Cancer Agents. Angew. Chem. Int. Ed. 2020, 59, 11046-11052. (Hot Paper, highlighted as inside back cover) Zou, T.;† Lok, C.-N.,† Wan, P.-K., Zhang, Z.-F., Fung, S.-K., Che, C.-M.* Anticancer Metal N-Heterocyclic carbene complexes of gold, platinum and palladium, Curr. Opin. Chem. Biol., 2018, 43, 30-36. Fung, S. K.;† Zou, T.;† Cao, B.; Lee, P.-Y.; Fung, Y. M. E.; Hu, D.; Lok, C.-N.; Che, C.-M.*, Cyclometallated Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands Engage Multiple Anti-Cancer Molecular Targets, Angew. Chem. Int. Ed. 2017, 56, 3892-3896. (Very Important Paper). Fung, S. K.;† Zou, T.;† Cao, B.; Chen, T.; To, W.-P.; Yang, C.; Lok, C.-N.; Che, C.-M.*, Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA, Nat. Commun. 2016, 7, 10655. Zou, T.; Lum, C. T.; Lok, C.-N.; Zhang, J.-J.; Che, C.-M.*, Chemical biology of anticancer gold(III) and gold(I) complexes. Chem. Soc. Rev. 2015, 44, 8786-8801 (Outside Front Cover). Tsai, J. L.-L.;† Zou, T.;† Liu, J.; Chen, T.; Chan, A. O.-Y.; Yang, C.; Lok, C.-N.; Che, C.-M.*, Luminescent platinum(ii) complexes with self-assembly and anti-cancer properties: hydrogel, pH dependent emission color and sustained-release properties under physiological conditions. Chem. Sci. 2015, 6, 3823-3830. Zou, T.; Lum, C. T.; Lok, C.-N.; To, W.-P.; Low, K.-H.; Che, C.-M.*, A Binuclear Gold(I) Complex with Mixed Bridging Diphosphine and Bis(N-Heterocyclic Carbene) Ligands Shows Favorable Thiol Reactivity and Inhibits Tumor Growth and Angiogenesis In Vivo. Angew. Chem. Int. Ed. 2014, 53, 5810-5814. Zou, T.;† Liu, J.;† Lum, C. T.; Ma, C.; Chan, R. C.-T.; Lok, C.-N.; Kwok, W.-M.; Che, C.-M.*, Luminescent Cyclometalated Platinum(II) Complex Forms Emissive Intercalating Adducts with Double Stranded DNA and RNA: Differential Emissions and Anticancer Activities. Angew. Chem. Int. Ed. 2014, 53, 10119-10123. Lok, C.-N.;† Zou, T.;† Zhang, J.-J.; Lin, I. W.-S.; Che, C.-M.*, Controlled-Release Systems for Metal-Based Nanomedicine: Encapsulated/Self-Assembled Nanoparticles of Anticancer Gold(III)/Platinum(II) Complexes and Antimicrobial Silver Nanoparticles. Adv. Mater. 2014, 26, 5550-5557. Zou, T.; Lum, C. T.; Chui, S. S.-Y.; Che, C.-M.*, Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands: Thiol “Switch-on” Fluorescent Probes and Anti-Cancer Agents. Angew. Chem. Int. Ed. 2013, 52, 2930-2933 (Very Important Paper)

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