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个人简介

教育经历 2007.09 - 2012.07 兰州大学,博士,导师:王锐 教授 2003.09 - 2007.07 兰州大学,学士 工作经历 2017.05 - 至今 中山大学药学院,教授 2012.09 - 2017.02 荷兰格罗宁根大学,博士后,合作导师:Ben L. Feringa (2016诺贝尔化学奖得主)

研究领域

化学能驱动分子机器的设计合成 多肽药物与手性药物的研发 光控分子开关以及超分子催化体系的设计

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Geshuyi Chen, Zhe Chang, Pei Yuan, Si Wang, Yongxiu Yang*, Xiaolei Liang* and Depeng Zhao*, Late-stage functionalization of 5-nitrofurans derivatives and their antibacterial activities, RSC Adv., 2023,13, 3204-3209 Zhanyong Tang, Ke Mo, Xiaoqiang Ma, Jialin Huang, Depeng Zhao*, para-Selective Radical Trifluoromethylation of Benzamide Derivatives via Iminium Intermediates, Angew. Chem. Int. Ed., 2022, DOI: 10.1002/anie.202208089 Hong Wang, Zhe Chang, Guo-di Cai, Ping Yang, Jiang-he Chen, Shan-shu Yang, Yin-feng Guo, Ming-yu Wang, Xue-hua Zheng, Jin-ping Lei, Pei-qing Liu, De-peng Zhao* & Jun-jian Wang*, The novel indomethacin derivative CZ-212-3 exerts antitumor effects on castration-resistant prostate cancer by degrading androgen receptor and its variants. Acta Pharmacol Sin (2021). https://doi.org/10.1038/s41401-021-00738-w Zhe Chang, Jialin Huang, Si Wang, Geshuyi Chen, Heng Zhao, Rui Wang* & Depeng Zhao*, Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles. Nat. Commun. 12, 4342 (2021). https://doi.org/10.1038/s41467-021-24671-y Yu Zhang, Zhe Chang, Heng Zhao, Stefano Crespi, Ben L. Feringa*, and Depeng Zhao*,A Chemically Driven Rotary Molecular Motor Based on Reversible Lactone Formation with Perfect Unidirectionality. Chem, 2020, 6, 2420-2429. https://doi.org/10.1016/j.chempr.2020.07.025 Ajmal Khan*, Heng Zhao,Meina Zhang, Shahid Khan,Depeng Zhao*,Regio- and Enantioselective Synthesis of Sulfone-Bearing Quaternary Carbon Stereocenters by Pd-Catalyzed Allylic Substitution. Angew. Chem. Int. Ed. 2020, 59,1340 –1345. https://doi.org/10.1002/anie.201910378 Zhe Chang,Tong Ma,Yu Zhang,Zheng Dong,Heng Zhao,Depeng Zhao* Synthesis of Functionalized Indoles via Palladium-Catalyzed Cyclization of N-(2-allylphenyl) Benzamide: A Method for Synthesis of Indomethacin Precursor.Molecules 2020, 25(5), 1233. https://doi.org/10.3390/molecules25051233 Depeng Zhao, Thomas van Leeuwen, Jinling Cheng, Ben L. Feringa*, Dynamic Control of Chirality and Self-Assembly of Double–Stranded Helicates with Light, Nature Chemistry, 2017, 9, 250-256. Depeng Zhao, Thomas M. Neubauer, and Ben L. Feringa*, Dynamic Control of Chirality in Phosphine Ligands for Enantioselective Catalysis, Nature Communications, 2015, 6652. Depeng Zhao, Linqing Wang, Dongxu Yang, Yixin Zhang and Rui Wang*, Highly Diastereo- and Enantioselective Synthesis of α-Alkyl Norstatine Derivatives: Catalytic Asymmetric Mannich Reactions of 5H-Oxazol-4-ones, Angew. Chem. Int. Ed., 2012, 51, 7523 –7527. Depeng Zhao, Dongxu Yang, Yijie Wang, Yuan Wang, Linqing Wang, Lijuan Mao and Rui Wang*, Enantioselective Mannich reaction of a highly reactive Horner–Wadsworth–Emmons reagent with imines catalyzed by a bifunctional thiourea, Chem. Sci., 2011, 2, 1918-1921. Depeng Zhao, Martín Fañanás-Mastral, Mu-Chieh Chang, Edwin Otten, and Ben L. Feringa*, Asymmetric Synthesis of N,O-Heterocycles Derivatives via Iridium-Catalysed Intramolecular Enantioselective Allylic Substitution with Amides, Chem. Sci., 2014, 5,4216-4220. Depeng Zhao, and Rui Wang*, Recent Developments in Metal Catalyzed Asymmetric Addition of Phosphorus Nucleophiles, Chem. Soc. Rev., 2012, 41, 2095-2108. Depeng Zhao, Lijuan Mao, Linqing Wang, Dongxu Yang, and Rui Wang*, Catalytic Asymmetric Construction of Tetrasubstituted Carbon Stereocenters by Conjugate Addition of Dialkyl Phosphine Oxides to β,β-Disubstituted α,β-Unsaturated Carbonyl Compounds, Chem. Commun., 2012, 48, 889–891. Depeng Zhao, Lijuan Mao, Yuan Wang, Dongxu Yang, Quanliang Zhang, and Rui Wang*, Catalytic Asymmetric Hydrophosphinylation of α,β-Unsaturated N-Acylpyrroles: Application of Dialkyl Phosphine Oxides in Enantioselective Synthesis of Chiral Phosphine Oxides or Phosphines, Org. Lett. 2010, 12, 1880-1882. Depeng Zhao, Lijuan Mao, Dongxu Yang, and Rui Wang*, Zinc-Mediated Asymmetric Additions of Dialkylphosphine Oxides to α,β-Unsaturated Ketones and N-Sulfinylimines, J. Org. Chem., 2010, 75, 6756. Depeng Zhao, Linqing Wang, Dongxu Yang, Yixin Zhang and Rui Wang*, Highly Efficient Asymmetric Michael Addition of Diaryl Phosphine Oxides to α,β-Unsaturated N-Acylated Oxazolidin-2-ones, Chem. Asian J., 2012,7, 881-883. Thomas M. Neubauer , Thomas van Leeuwen, Depeng Zhao , Anouk S. Lubbe , Jos C. M. Kistemaker , and Ben L. Feringa*, Asymmetric Synthesis of First Generation Molecular Motors, Org. Lett., 2014, 16 , 4220–4223. Thomas van Leeuwen, G. Henrieke Heideman, Depeng Zhao, Sander J. Wezenberg * and Ben L. Feringa *, In situ control of polymer helicity with a non-covalently bound photoresponsive molecular motor dopant, Chem. Commun., 2017, 53, 6393-6396.

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