Gibbs-Davis, Julianne M. - University of Alberta

研究领域

Molecular Recognition at Buried Solid/Liquid Interfaces Many systems, from the cellular environment to biosensors and heterogeneous catalysis, involve noncovalent interactions between species in solution and those confined to a membrane or solid. Directly monitoring such binding events is difficult because few techniques are sensitive to interactions at an interface and are instead overwhelmed by the sea of molecules in the bulk. However, using surface specific nonlinear optical techniques such as second harmonic generation (SHG) and sum frequency generation (SFG), we can selectively observe interfacial binding allowing us to characterize the thermodynamic and kinetic parameters governing these processes without the use of bulky labels, in situ and in real time.

近期论文

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Kausar, A.; Osman, E.; Gibbs-Davis, J. M. "Isothermal, Real-time Detection of Single Nucleotide Polymorphisms with Lesion-Induced DNA Amplification" 2014, in preparation. Alladin-Mustan, B. S.;* Mitran, C. J.;* Gibbs-Davis, J. M. "Combining Different Destabilizing Groups to Tune the Temperature in Isothermal Lesion-Induced DNA Amplification" 2014, submitted. (joint first-authors) Weeraman, C. N.; Azam, M. S.; Li, Z.; Gibbs-Davis, J. M. "The Thermal Reorganization of DNA Immobilized at the Silica/Buffer Interface: A Vibrational Sum Frequency Generation Investigation,” 2014, submitted. Li, Z.; Weeraman, C. N.; Gibbs-Davis, J. M. "Ketone Binding at Amino and Ureido Monolayer/Solvent Interfaces Studied by Nonlinear Optical Techniques,” J. Phys. Chem. C 2014, accepted. Li, Z; Weeraman, C. N.; Gibbs-Davis, J. M. "Following the Azide-Alkyne Cycloaddition at the Silica/Solvent Interface with Sum Frequency Generation" ChemPhysChem 2014, accepted. Azam, M. S.; Darlington, A.; Gibbs-Davis, J. M. "Influence of Concentration on Specific Ion Effects at the Silica/Water Interface" J. Phys.: Condens. Matter 2014, accepted. Azam, M. S.; Gibbs-Davis, J. M. "Monitoring DNA Hybridization and Thermal Dissociation at the Silica/Water Interface using Resonantly Enhanced Second Harmonic Generation Spectroscopy,” Anal. Chem. 2013, 85, 8031–8038. (Editor's Highlight) dx.doi.org/10.1021/ac401009u Diaz, J. A.; Gibbs-Davis, J. M. "Sharpening the Thermal Dissociation of DNA from Gold Nanoparticles: A Sequential Release Strategy" Small, 2013, 9, 2862–2871. (Selected for Front Cover) dx.doi.org/10.1002/smll.201202278 Azam, M. S.; Weeraman, C. N.; Gibbs-Davis, J. M. "Halide-Induced Cooperative Acid-Base Behavior at a Negatively Charged Interface” J. Phys. Chem. C 2013, 117, 8840-8850. dx.doi.org/10.1021/jp401164r Kausar, A.; Mitran, C. J.; Li, Y.; Gibbs-Davis, J. M. "Rapid DNA Self‐Replication Induced by A Destabilizing Lesion" Angew. Chem. Int. Ed. 2013, 52, 10577-10581. (Selected for Back Cover and Hot Article) dx.doi.org/10.1002/anie.201303225 Azam, M. S.; Weeraman, C.; Gibbs-Davis, J. M. "Specific Cation Effects on the Biomdal Acid-Base Behavior of the Silica/Water Interface" J. Phys. Chem. Lett. 2012, 3, 1269-1274. dx.doi.org/10.1021/jz300255x Sikder, M. D.; Gibbs-Davis, J. M. "The Influence of Gap Length on Cooperativity of Association in DNA-Modified Gold Nanoparticle Aggregates" J. Phys. Chem. C 2012, 116, 11694-11701. dx.doi.org/10.1021/jp209209x Diaz, J. A.; Grewer, D. M.; Gibbs-Davis, J. M. " Tuning Ratios, Densities, and Supramolecular Spacing in Multifunctional DNA-Modified Gold Nanoparticles" Small, 2012, 8, 873–883. dx.doi.org/10.1002/smll.201101922 Kausar, A.; McKay, R. D.; Lam, J.; Bhogal, R. S.; Tang, A. Y.; Gibbs-Davis, J. M. "Tuning DNA Stability to Achieve Turnover in Template for an Enzymatic Ligation Reaction" Angew. Chem. 2011, 50, 8922-8926. http://dx.doi.org/10.1002/anie.201102579 Azam, M. S.; Fenwick, S. L.; Gibbs-Davis, J. M. " Orthogonally Reactive SAMs as a General Platform for Bifunctional Silica Surfaces" Langmuir, 2011, 27, 741-750. http://dx.doi.org/10.1021/la1041647 Buchbinder, A.; Gibbs-Davis, J. M.; Stokes, G.; Peterson, M.; Weitz, E.; Geiger, F. M. “Method for Evaluating Vibrational Mode Assignments in Surface-Bound Cyclic Hydrocarbons Using Sum Frequency Generation” J. Phys. Chem. C 2011, 115, 18284–18294. Boman, F. C.; Gibbs-Davis, J. M.; L. M. Heckman; Stepp, B. R.; Nguyen, S. T.; Geiger, F. M. "DNA Single and Double Strands at Aqueous/Solid Interfaces and Their Chiral Second Harmonic Generation Activity," J. Am. Chem. Soc. 2009, 131, 844-848. http://dx.doi.org/10.1021/ja808007b Lytton-Jean, A. K.;* Gibbs-Davis, J. M.;* Long, H.; Schatz, G. C.; Mirkin, C. A.; Nguyen, S. T. "Highly Cooperative Behavior of Peptide Nucleic Acid-Linked DNA-Modified Gold Nanoparticle and Comb Polymer Aggregates," Adv. Mater. 2009, 21, 706-709. (*Joint first authors) Gibbs-Davis, J. M.; Kruk, J. K.; Konek, C. T.; Scheidt, K. A.; Geiger, F. M. “Jammed Acid-Base Reactions at Interfaces,” J. Am. Chem. Soc. 2008, 130, 15444-15447. http://dx.doi.org/10.1021/ja804302s Stokes, G. Y.; Buchbinder, A. M. Gibbs-Davis, J. M.; Scheidt, K. A.; Geiger, F. M. "Chemically Diverse Environmental Interfaces and Their Reactions with Ozone Studied by Vibrational Sum Frequency Generation," Vibrat. Spectrosc. 2009, 50, 86-98. http://dx.doi.org/10.1016/j.vibspec.2008.08.