沈慧勇 - 中山大学 - 孙逸仙纪念医院

个人简介

中山大学二级教授、主任医师、研究员，医学博士、中山大学博士生导师，中山大学名医，享受国务院特殊津贴专家，骨外科学术带头人。现任中山大学附属第八医院院长，广东省强直性脊柱炎综合诊治工程技术研究中心主任，广东省脊柱脊髓疾病科研中心主任、中山大学脊髓损伤研究所所长。学术任职有中华医学会广东分会骨科专业委员会主任委员、中华医学会骨科学分会常委、《中华骨科杂志》副主编等。长期从事脊柱肿瘤、退变、强直性脊柱炎和脊髓损伤的研究，目前已发表SCI论文数十篇，承担国家及省部级科研项目多项，获得多个专利，并编有《外科学》、《脊髓损伤》、《术中神经电生理监护》等多部专著。

研究领域

脊柱骨盆肿瘤en bloc(整块)切除、脊柱畸形矫正、强直性脊柱炎、脊髓损伤、颈椎病、腰椎间盘突出症等脊柱外科疾病。

近期论文

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Xie Zhongyu，Wang Peng，Li Yuxi，Deng Wen，Zhang Xin，Su Hongjun，Li Deng，Wu Yanfeng，Shen Huiyong，Imbalance between BMP2 and Noggin induces abnormal osteogenic differentiation of mesenchymal stem cells in ankylosing spondylitis. Arthritis Rheumatol.2015 Sep 28. [Epub ahead of print] Wang Le，Gao Liangbin，Jin Dan，Wang Peng，Yang Bo，Deng Wen，Xie Zhongyu，Tang Yong，*Wu Yanfeng，Shen Huiyong. The Relationship of Bone Mineral Density to Oxidant/Antioxidant Status and Inflammatory and Bone Turnover Markers in a Multicenter Cross-Sectional Study of Young Men with Ankylosing Spondylitis. Calcified Tissue International，97(1)，pp 12-22，2015/7. Li Deng，Wang Peng，Li Yuxi，Xie Zhongyu，Wang Le，Su Hongjun，Deng Wen，Wu Yanfeng，Shen Huiyong. All-Trans Retinoic Acid Improves the Effects of Bone Marrow-Derived Mesenchymal Stem Cells on the Treatment of Ankylosing Spondylitis: An In Vitro Study. Stem Cells Int. 2015: 484528. Li Y，Wang P，Xie Z，Huang L，Yang R，Gao L，Tang Y，Zhang X，Ye J，Chen K，Cai Z，Wu Y and Shen H. Whole Genome Expression Profiling and Signal Pathway Screening of MSCs in Ankylosing Spondylitis. Stem Cells Int. 2014:913050. Wang W，Wang P，Li S，Yang J，Liang X，Tang Y，Li Y，Yang R，Wu Y，Shen H. Methylprednisolone inhibits the proliferation and affects the differentiation of rat spinal cord-derived neural progenitor cells cultured in low oxygen conditions by inhibiting HIF-1alpha and Hes1 in vitro. Int J Mol Med 2014;34(3):788-95. Wang P，Li Y，Huang L，Yang J，Yang R，Deng W，Liang B，Dai L，Meng Q，Gao L，Chen X，Shen J，Tang Y，Zhang X，Hou J，Ye J，Chen K，Cai Z，Wu Y，Shen H. Effects and Safety of Allogenic Mesenchymal Stem Cells Intravenous Infusion in Active Ankylosing Spondylitis Patients Who Failed NSAIDs: A 20 Week Clinical Trial. Cell Transplant. 2013 May 22. Gao L，Wang L，Su B，Wang P，Ye J，Shen H. The vascular supply to the spinal cord and its relationship to anterior spine surgical approaches.Spine J. 2013 Aug;13(8):966-73. Yang R，Zhang Z，Song B，Wang P，Wang L，Li W，Shen H. Ratio of T helper to regulatory T cells in synovial fluid and postoperative joint laxity after allograft anterior cruciate ligament reconstruction. Transplantation. 2012 Dec 15;94(11):1160-6. Huang L，Chen K，Ye JC，Tang Y，Yang R，Wang P，Shen HY. Modified total en bloc spondylectomy for thoracolumbar spinal tumors via a single posterior approach. Eur Spine J. 2012 Aug 4. Huang L，Lin X，Tang Y，Yang R，Li AH，Ye JC，Chen K，Wang P，Shen HY. Quantitative assessment of spinal cord perfusion by using contrast-enhanced ultrasound in a porcine model with acute spinal cord contusion. Spinal Cord. 2012 Oct 9. Li SY，Wang P，Tang Y，Huang L，Wu YF，Shen HY. Analysis of methylprednisolone-induced inhibition on the proliferation of neural progenitor cells in vitro by gene expression profiling. Neurosci Lett. 2012 Sep 27;526(2):154-9. Huang L，Dai T，Lin X，Zhao X，Chen X，Wang C，Li X，Shen H，Wang X. MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells. Biochem Biophys Res Commun. 2012 Aug 24;425(2):127-33. Wu Y，Ren M，Yang R，Liang X，Ma Y，Tang Y，Huang L，Ye J，Chen K，Wang P，Shen H. Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4+CCR6+ Th/Treg cell subset imbalance in ankylosing spondylitis. Arthritis Research & Therapy. 2011 Feb;13(1):R29. Meng QQ，Liang XJ，Wang P，Wang XP，Yang JW，Wu YF，Shen HY. Rosiglitazone enhances the proliferation of neural progenitor cells and inhibits inflammation response after spinal cord injury. Neurosci Lett. 2011 Oct 10;503(3):191-5. Wu Y，Tang Y，Liang X，Lin Y，Yang W，Ma Y，Huang L，Yang R，Ye J，Chen K，Shen H. The role of increased frequency of treg cells in patients with chronic osteomyelitis. Orthopedics. 2011 Jan 1;34(2):98. Wu YF，Liang XJ，Liu YY，Gong W，Liu JX，Wang XP，Zhuang ZQ，Guo Y，Shen HY. Antisense oligonucleotide targeting survivin inhibits growth by inducing apoptosis in human osteosarcoma cells MG-63. Neoplasma. 2010;57(6):501-6. Yin B，Tang Y，Ye J，Wu Y，Wang P，Huang L，Yang R，Shen H. Sensitivity and Specificity of In Vivo Diffusion-Weighted MRI in Acute Spinal Cord Injury. Journal of Clinical Neuroscience，2010 Sep;17(9):1173-9. Liang X，Da M，Zhuang Z，Wu W，Wu Z，Wu Y，Shen H. Effects of Survivin on cell proliferation and apoptosis in MG-63 cells in vitro[J].Cell Biol Int. 2009 Jan;33(1):119-24. Pan Q，Wu Y，Lin T，Yao H，Yang Z，Gao G，Song E，Shen H. Bone morphogenetic protein-2 induces chromatin remodeling and modification at the proximal promoter of Sox9 gene[J].Biochem Biophys Res Commun. 2009 Feb 6;379(2):356-61. Zhongyu Xie#, Jinteng Li#, Peng Wang, Yuxi Li, Xiaohua Wu, Shan Wang, Wen Deng, Hongjun Su, Zhenhua Liu, Shuizhong Cen, Yi Ouyang, Yanfeng Wu*, Huiyong Shen*Differential expression profiles of long noncoding RNAs and messenger RNAs of osteogenically differentiated mesenchymal stem cells in ankylosing spondylitis. Journal of Rheumatology. 2016 (Accept)