陈样新 - 中山大学 - 孙逸仙纪念医院

个人简介

陈样新，副教授，博士，先后于华中科技大学同济医学院（原同济医科大学）、浙江大学及中山大学就读，现为中山大学孙逸仙纪念医院心血管内科博士/硕士生导师，并担任医院心力衰竭专科主任一职。

研究领域

1、明确了C-反应蛋白在促内皮功能障碍及斑块不稳定中的重要作用及其可能机制，同时也对阿托伐他汀改善内皮功能的相关机制进行了初步探讨，证明了血管外膜脂肪组织炎症机制在其中的关键调控作用。 2、对血管新生、内皮间质转化（EndMT）与心室重构的关系和机制进行了探讨，研究了炎症、机械应力等诱导血管内皮发生EndMT，促进心肌和血管重构的现象和机制。

近期论文

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①　Chen YX#, Wang XQ#, Fang CF#, Wang JF*, Tang LJ. Value of BNP and tumour marker CA125 in patients with heart failure. Acta Cardiol. 2008;63(4):501-6. ②　Chen YX#, Wang XQ#, Wang JF*, Fang CF, Tang LJ, Nie RQ, Zhou SX, Wei YL. Glucometabolic state of in-hospital patients with primary hypertension in sub-population of partial regions in China. J Hum Hypertens. 2008;22(5):346-51. ③　Chen YX#, Wang JF*, Nie RQ, Zhou SX. Endogenous pro-resolving and anti-inflammatory lipid mediators: the new hope of atherosclerotic diseases. Med Hypotheses. 2008;71(2):237-40. ④　Chen YX#, Fang CF#, Wang XQ#, Nie RQ, Li GQ, Tang LJ, Zhou SX, Wang JF*. Glucometabolic state of in-hospital primary hypertension patients with normal fasting blood glucose in a sub-population of China. Diabetes Metab Res Rev. 2009;25(4):357-62. ⑤　Chen YX#, Wang JF*, Yao YJ, Yuan WL, Kong MY, Lin YQ, Geng DF, Nie RQ. CRP regulates the expression and activity of tissue factor as well as tissue factor pathway inhibitor via NF-kappaB and ERK 1/2 MAPK pathway. FEBS Lett. 2009;583(17):2811-8. ⑥　Fang C#, Chen Y#, Nie R, Li G, Xu G, Zhou S, Wang J*. Retrospective analysis of risk factors in young patients with coronary artery disease in Guangdong and Zhejiang, China. Acta Cardiol. 2009;64(2):195-9. ⑦　Chen YX#, Luo NS, Lin YQ, Yuan WL, Xie SL, Nie RQ, Wang JF*. Selective estrogen receptor modulators promising for cardiac syndrome X. J Postgrad Med. 2010;56(4):328-31. ⑧　Chen YX#, Wang XQ#, Fu Y, Yao YJ, Kong MY, Nie RQ, Wang JF*. Pivotal role of inflammation in vascular endothelial dysfunction of hyperlipidemic rabbit and effects by atorvastatin. Int J Cardiol. 2011;146(2):140-4. ⑨　陈样新#，罗年桑*，王晓俏，林永青，聂如琼，王景峰. 脂氧素A4抑制单核巨噬细胞源性树突状细胞的分化及成熟. 中国动脉粥样硬化杂志. 2011;19(5):409-12. ⑩　Chen YX#, Wang XQ#, Mai JT#, Zhao XM, Liang YH, Gu MN, Chen ZQ, Nie RQ, Wang JF*. C-reactive protein promotes vascular endothelial dysfunction partly via activating adipose tissue inflammation in hyperlipidemic rabbits. Int J Cardiol. 2013;168(3):2397-403. 11　Mai JT#, Qiu Q#, Lin YQ, Luo NS, Zhang HF, Wen ZZ, Wang JF*, Chen YX*. Angiotensin II-derived reactive oxygen species promote angiogenesis in human late endothelial progenitor cells through heme oxygenase-1 via ERK1/2 and AKT/PI3K pathways. Inflammation. 2014;37(3):858-70. 12　Wang XQ#, Luo NS#, Chen ZQ#, Lin YQ, Gu MN, Chen YX*. Atorvastatin attenuates TNF-alpha production via heme oxygenase-1 pathway in LPS-stimulated RAW264.7 macrophages. Biomed Environ Sci. 2014;27(10):786-93. 13　Wang XQ#, Lin YQ#, Luo NS, Chen ZQ, Gu MN, Wang JF, Chen YX*. Short-term intensive atorvastatin therapy improves endothelial function partly via attenuating perivascular adipose tissue inflammation through 5-lipoxygenase pathway in hyperlipidemic rabbits. Chin Med J (Engl). 2014;127(16):2953-9. 14　Mai JT#, Hu QS#, Xie Y#, Su SC, Qiu Q, Yuan WL, Yang Y, Song EW, Chen YX*, Wang JF*. Dyssynchronous Pacing Triggers Endothelial-Mesenchymal Transition Through Heterogeneity of Mechanical Stretch in a Canine Model. Circ J. 2014;79(1):201-9. 15　Qiu Q#, Chen YX#, Mai JT, Yuan WL, Wei YL, Yang L*, Wang JF*. Effects of Cardiac Resynchronization Therapy on Left Ventricular Remodeling and Dyssynchrony in Patients with Left Ventricular Noncompaction and Heart Failure. Int J Cardiovas Imag. 2015;31(2):329-37. 16　Mai JT#, Wang F#, Qiu Q, Tang BZ, Lin YQ, Luo NS, Yuan WL, Wang XL, Chen QC, Wang JF*, Chen YX*. Tachycardia pacing induces myocardial neovascularization and mobilizes circulating endothelial progenitor cells partly via SDF-1 pathway in canines. Heart Vessels. 2016;31(2):230-40. 17　Chen J#, Tang B#, Lin Y, Ru Y, Wu M, Wang X, Chen Q, Chen Y*, Wang J*. Validation of the Ability of SYNTAX and Clinical SYNTAX Scores to Predict Adverse Cardiovascular Events After Stent Implantation: A Systematic Review and Meta-Analysis. Angiology. 2015 Nov 26. pii: 0003319715618803. [Epub ahead of print] 18　Liu Z#, Chen Y#, Tang B*, Wang X, Chen Q, Li H, Wang J, Deng Q, Zhu S. Automatic de-identification of electronic medical records using token-level and character-level conditional random fields. J Biomed Inform. 2015;58 Suppl:S47-52. 19　Ying R#, Wang XQ#, Yang Y#, Gu ZJ, Mai JT, Qiu Q, Chen YX*, Wang JF*. Hydrogen sulfide suppresses endoplasmic reticulum stress-induced endothelial-to-mesenchymal transition through Src pathway. Life Sci. 2016;144:208-17.