于风燕 - 中山大学 - 孙逸仙纪念医院

个人简介

风燕，研究员，外科学博士，毕业于中山大学，现为中山大学孙逸仙纪念医院乳腺肿瘤医学部博士生导师

研究领域

从事乳腺癌的临床和基础研究。包括：早期乳腺癌的保留乳房根治术，前哨淋巴结活检术，乳腺癌整形保乳术等，以及早期乳腺癌的个体化综合治疗，局部晚期乳腺癌的新辅助治疗，复发转移乳腺癌的个体化综合治疗以及靶向治疗。基础研究包括：乳腺癌干细胞的特性及调控机制，非编码RNA在乳腺癌转移过程中的调控机制，肿瘤微环境与乳腺癌细胞相互作用的调控机制，乳腺癌个体化治疗靶点以及预后指标的筛选等。

近期论文

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1.Hu X, Su F, Qin L, Jia W, Gong C, Yu F, Guo J, Song E*. Stable RNA interference of ErbB-2 gene synergistic with epirubicin suppresses breast cancer growth in vitro and in vivo. Biochemical and Biophysical Research Communications 2006: 346(3): 776-85. （影响因子：2.37） 2.Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J*, Song E*. Let-7 regulates self-renewal and tumorigenesis of breast cancer cells. Cell 2007: 131:1109-23. （影响因子：31） 3.Dykxhoorn DM, Wu Y, Xie H, Yu F, Lal A, Petrocca F, Martinvalet D, Song E, Lim B, Lieberman J*. miR-200 enhances breast cancer cell colonization to form distant metastases. PLoS One. (2009), 4(9):e7181 （影响因子：3.06） 4.Yu F, Deng H, Yao H, Liu Q, Su F, Song E*. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene 2010; 29:4194-204. （影响因子：7.93） 5.Chen J#, Yao Y#, Gong C#, Yu F#, Su S, Chen J, Liu B, Deng H, Wang F, Lin L, Yao H, Sun F, Karen S. Anderson, Liu Q, Mark E. Ewen, Yao X*, Song E*. CCL18 from tumor associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell (2011), 19, 541–555. （影响因子：23.2） 6.Wu G#, Yu F#, Xiao Z, Xu K, Xu J, Tang W, Wang J, Song E*. Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro. British J Cancer, 2011, 105(1):146-53. （影响因子：5.6） 7.Zhu Y#, Yu F#, Jiao Y, Feng J, Tang W, Yao H, Gong C, Chen J, Su F, Zhang Y*, Song E*. Reduced miR-128 in breast tumor–initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5, Clinical Cancer Research,2011, 17(22); 7105-15. （影响因子：8.74） 8.Yu F#, Jiao Y#, Zhu Y#, Wang Y, Zhu J, Cui X, Liu Y, He Y, Park E Y, Zhang H, Lv X, Ma K, Su F, Park J H*, Song E*. MiR-34c Down-regulation via DNA Methylation Promotes Self-renewal and Epithelial-Mesenchymal Transition in Breast Tumor-Initiating Cells. Journal of Biological Chemistry, 2012, 287(1), 465-73. （影响因子：4.26） 9.Zhao R, Wu J, Jia W, Gong C, Yu F, Ren Z, Chen K, He J, Su F*. Plasma miR-221 as a Predictive Biomarker for Chemoresistance in Breast Cancer Patients who Previously Received Neoadjuvant Chemotherapy. Onkologie. 2011;34(12):675-80. （影响因子：1.52） 10.Lv XB, Jiao Y, Qing Y, Hu H, Cui X, Lin T, Song E, Yu F*. miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro. Chin J Cancer. 2011; 30(12):821-30. （影响因子：2.8） 11.Yu S#, Liu Y#, Wang J, Guo Z, Zhang Q, Yu F, Zhang Y, Huang K, Li Y, Song E, Zheng XL, Xiao H*. Circulating microRNA profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma. J Clin Endocrinol Metab. 2012; 97(6):2084-92. （影响因子：5.53） 12.Tang W#, Zhu J#, Su S, Wu W, Liu Q, Su F*, Yu F*. MiR-27 as a Prognostic Marker for Breast Cancer Progression and Patient Survival. Plos One. 2012.7(12): e51702. （影响因子：3.06） 13.Yao YD#, Sun TM#, Huang SY, Dou S, Lin L, Chen JN, Ruan JB, Mao CQ, Yu FY, Zeng MS, Zang JY, Liu Q, Su FX, Zhang P, Lieberman J*, Wang J*, Song E*. Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Sci Transl Med. 2012; 4(130):130ra48. （影响因子：16.26） 14.Hu H#, Li S#, Cui X, Lv X, Jiao Y, Yu F, Yao H, Song E, Wang M, Chen Y, Lin L*. The overexpression of hypomethylated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulphate proteoglycan 2 (HSPG2). J Biol Chem. 2013, 288(16):10973-85. （影响因子：4.26） 15.Liu Y#, Li H#, Feng J#, Cui X#, Huang W, Li Y, Su F, Liu Q, Zhu J, Lv X, Chen J, Huang D, Yu F*. Lin28 Induces Epithelial-to-Mesenchymal Transition and Stemness via Downregulation of Let-7a in Breast Cancer Cells, Plos One,2013; 8(12):e83083. （影响因子：3.06） 16.Li HY, Cui XY, Wu W, Yu FY, Yao HR, Liu Q, Chen JQ*. Pyk2 and Src Mediate Signaling to CCL18-Induced Breast Cancer Metastasis. J Cell Biochem. 2014, 115(3):596-603. （影响因子：3.45） 17.Tang W#, Yu F#, Yao H#, Cui X, Jiao Y, Lin L, Chen J, Yin D, Song E*, Liu Q*, MiR-27a regulates endothelial differentiation of breast cancer stem like cells. Oncogene 2014, 33(20):2629-38. （影响因子：7.93） 18.Wu J, Li S, Jia W, Deng H, Chen K, Zhu L, Yu F*, Su F*. Reduced Let-7a Is Associated with Chemoresistance in Primary Breast Cancer. PLoS One. 2015 Jul 28;10(7):e0133643. （影响因子：3.06）