个人简介
B.A., Mount Holyoke College, 1997
Ph.D., Medical College of Wisconsin 2007
Postdoctoral Fellow, The Scripps Research Institute and University of
California, San Diego, 2007-2012.
研究领域
Analytical, Biochemistry, & Biology
My research group focuses on utilizing novel technologies to develop new therapeutics and diagnostics for autoimmune and inflammatory diseases. The development of mutli-functional drugs, i.e. theranostics, allows simultaneous imaging of tissue pathology coupled with treatment, increasing efficacy and reducing toxicity. To this end, my group uses mass spectrometry-based metabolomics, molecular imaging, and viral nanoparticles to identify and target cellular pathways that are involved in disease pathogenesis.
近期论文
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Plummer EM, Thomas D, Destito G, Shriver LP, Manchester M. (2012) Interaction of cowpea mosaic virus nanoparticles with surface vimentin and inflammatory cells in atherosclerotic lesions. Nanomedicine (Lond). 7(6):877-88
Patti GJ, Yanes O, Shriver LP, Courade JP, Tautenhahn R, Manchester M, Siuzdak G. (2012) Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin. Nat Chem Biol. 22;8(3):232-4.
Shriver LP, Manchester M. (2011) Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Sci Rep. 1:79.
Patti GJ, Shriver LP, Wassif CA, Woo HK, Uritboonthai W, Apon J, Manchester M, Porter FD, Siuzdak G. (2010) Nanostructure-initiator mass spectrometry (NIMS) imaging of brain cholesterol metabolites in Smith-Lemli-Opitz syndrome. Neuroscience. 170(3):858-64.
Patti GJ, Woo HK, Yanes O, Shriver L, Thomas D, Uritboonthai W, Apon JV, Steenwyk R, Manchester M, Siuzdak G. (2010) Detection of carbohydrates and steroids by cation-enhanced nanostructure-initiator mass spectrometry (NIMS) for biofluid analysis and tissue imaging. Anal Chem. 2010 Jan 1;82(1):121-8.
Shriver LP, Koudelka KJ, Manchester M. (2009) Viral nanoparticles associate with regions of inflammation and blood brain barrier disruption during CNS infection. J Neuroimmunol. 211(1-2):66-72.
Yanes O, Woo HK, Northen TR, Oppenheimer SR, Shriver L, Apon J, Estrada MN, Potchoiba MJ, Steenwyk R, Manchester M, Siuzdak G. (2009) Nanostructure initiator mass spectrometry: tissue imaging and direct biofluid analysis. Anal Chem. 81(8):2969-75.