个人简介

B.A., 1972, SUNY at Albany Ph.D., 1980, SUNY at Buffalo Postdoctoral fellow, 1980-1983, Northwestern University Assistant professor, 1983-1989, Case Western Reserve University Associate Professor, 1989-1990, Case Western Reserve University

研究领域

Inorganic, Organometallic & Organic Chemistry

My research interests focus on: The development of new silver based antimicrobials for nebulization into the lung to combat bacterial lung infections. The formation of PLGA-PEG and LTP nanoparticles containing silver carbene complexes for the treatment of systemic bacterial infections. The formation of PLGA-PEG and LTP nanoparticles with targeting groups such as folate on the surface for the treatment of cancers. The development of phosphazene polymers as proton conducting membrane materials for hydrogen fuel cells

近期论文

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Garner, Philip; Hu, Jieyu; Parker, Christopher G.; Youngs, Wiley J.; Medvetz, Doug, “The CuI-catalyzed exo-selective asymmetric multicomponent [C+NC+CC] coupling reaction”, Tetrahedron Letters 2007, 48(22), 3867-3870. http://dx.doi.org/10.1016/j.tetlet.2007.03.145 Kalikhman, Inna; Gostevskii, Boris; Kertsnus, Evgenia; Botoshansky, Mark; Tessier, Claire A.; Youngs, Wiley J.; Deuerlein, Stephan; Stalke, Dietmar; Kost, Daniel, “Competitive Molecular Rearrangements in Hexacoordinate Cyano-Silicon Dichelates”, Organometallics 2007, 26(10), 2652-2658. http://dx.doi.org/10.1021/om061176y Medvetz, Doug A.; Sloan-Stakleff, Kimberly; Schreiber, Tara; Custer, Paul D.; Hindi, Khadijah; Panzner, Matthew J.; Blanco, Denise; Taschner, Michael J.; Tessier, Claire A.; Youngs, Wiley J., “Ovarian Cancer Cyclic Amine and Thiaether Metal Complexes”, Journal of Medicinal Chemistry 2007, 50(7), 1703-1706. http://dx.doi.org/10.1021/jm060857s Kascatan-Nebioglu, Aysegul; Panzner, Matthew J.; Tessier, Claire A.; Cannon, Carolyn L.; Youngs, Wiley J., “N-Heterocyclic carbene-silver complexes: A new class of antibiotics”, Coordination Chemistry Reviews 2007, 251(5+6), 884-895. http://dx.doi.org/10.1016/j.ccr.2006.08.019 Garrison, Jered C.; Panzner, Matthew J.; Custer, Paul D.; Reddy, Venkat D.; Rinaldi, Peter L.; Tessier, Claire A.; Youngs, Wiley J., “Synthesis and Characterization of a Trigonal Bipyramidal Supramolecular Cage Based Upon Rhodium and Platinum Metal Centers”, Chemical Communications 2006, (44), 4644-4646. http://dx.doi.org/10.1039/b608991g Kascatan-Nebioglu, Aysegul; Melaiye, Abdulkareem; Hindi, Khadijah; Durmus, Semih; Panzner, Matthew J.; Hogue, Lisa A.; Mallett, Rebekah J.; Hovis, Christine E.; Coughenour, Marvin; Crosby, Seth D.; Milsted, Amy; Ely, Daniel L.; Tessier, Claire A.; Cannon, Carolyn L.; Youngs, Wiley J., “Synthesis from Caffeine of a Mixed N-Heterocyclic Carbene-Silver Acetate Complex Active against Resistant Respiratory Pathogens”, Journal of Medicinal Chemistry 2006, 49(23), 6811-6818. http://dx.doi.org/10.1021/jm060711t Dogan, Oezdemir; Koyuncu, Hasan; Garner, Philip; Bulut, Adnan; Youngs, Wiley J.; Panzner, Matthew, “New Zinc(II)-Based Catalyst for Asymmetric Azomethine Ylide Cycloaddition Reactions”, Organic Letters 2006, 8(21), 4687-4690. http://dx.doi.org/10.1021/ol061521f Garner, Philip; Kaniskan, H. Uemit; Hu, Jieyu; Youngs, Wiley J.; Panzner, Matthew, “Asymmetric Multicomponent [C+NC+CC] Synthesis of Highly Functionalized Pyrrolidines Catalyzed by Silver(I)”, Organic Letters 2006, 8(17), 3647-3650. http://dx.doi.org/10.1021/ol061113b Kalikhman, Inna; Gostevskii, Boris; Botoshansky, Mark; Kaftory, Menahem; Tessier, Claire A.; Panzner, Matthew J.; Youngs, Wiley J.; Kost, Daniel, “Octahedral and Bicapped-Tetrahedral Silicon Configurations in the Solid State and Their Dynamic Coexistence in Solution”, Organometallics 2006, 25(5), 1252-1258. http://dx.doi.org/10.1021/om0509802 Garrison, Jered C.; Tessier, Claire A.; Youngs, Wiley J., “Synthesis and crystallographic characterization of multi-donor N-heterocyclic carbene chelating ligands and their silver complexes: Potential use in pharmaceuticals”, Journal of Organometallic Chemistry 2005, 690(24-25), 6008-6020. http://dx.doi.org/10.1016/j.jorganchem.2005.07.102 Garrison, Jered C.; Youngs, Wiley J., “Ag(I) N-heterocyclic Carbene Complexes: Synthesis, Structure and Application”, Chemical Reviews (Washington, DC, United States) 2005, 105(11), 3978-4008. http://dx.doi.org/10.1021/cr050004s Gostevskii, Boris; Kalikhman, Inna; Tessier, Claire A.; Panzner, Matthew J.; Youngs, Wiley J.; Kost, Daniel, “Hexacoordinate Complexes of Silacyclobutane: Spontaneous Ring Opening and Rearrangement”, Organometallics 2005, 24(24), 5786-5788. http://dx.doi.org/10.1021/om0505559 Heston, Amy J.; Panzner, Matthew J.; Youngs, Wiley J.; Tessier, Claire A., “Lewis Acid Adducts of [PCl2N]3”, Inorganic Chemistry 2005, 44(19), 6518-6520. http://dx.doi.org/10.1021/ic050974y Al-Humydi, Abdulaziz; Garrison, Jered C.; Mohammed, Muqtar; Youngs, Wiley J.; Collins, Scott, “Propene polymerization using ansa-metallocenium ions: Catalyst deactivation processes during monomer consumption and molecular structures of the products formed”, Polyhedron 2005, 24(11), 1234-1249. http://dx.doi.org/10.1016/j.poly.2005.02.005 Custer, Paul D.; Garrison, Jered C.; Tessier, Claire A.; Youngs, Wiley J., “Anion Directed Synthesis of Paddlane and Trisilver Tweezer Complexes Based upon Silver Coordination Chemistry”, Journal of the American Chemical Society 2005, 127(16), 5738-5739. http://dx.doi.org/10.1021/ja050154k Al-Humydi, Abdulaziz; Garrison, Jered C.; Youngs, Wiley J.; Collins, Scott, “Propene polymerization using ansa-metallocenium ions: excess activator effects on polymerization activity and polymer microstructure. [Erratum to document cited in CA142:219600]”, Organometallics 2005, 24(7), 1784. http://dx.doi.org/10.1021/om050100j Melaiye, Abdulkareem; Youngs, Wiley J., “Silver and its application as an antimicrobial agent”, Expert Opinion on Therapeutic Patents 2005, (2005), 15(2), 125-130. http://dx.doi.org/10.1517/13543776.15.2.125 Melaiye, Abdulkareem; Sun, Zhaohui; Hindi, Khadijah; Milsted, Amy; Ely, Daniel; Reneker, Darrell H.; Tessier, Claire A.; Youngs, Wiley J., “Silver(I)-imidazole Cyclophane Gem-diol Complexes Encapsulated by Electrospun Tecophilic Nanofibers: Formation of Nanosilver Particles and Antimicrobial Activity”, Journal of the American Chemical Society 2005, 127(7), 2285-2291. http://dx.doi.org/10.1021/ja040226s Garrison, Jered C.; Panzner, Matthew J.; Tessier, Claire A.; Youngs, Wiley J, “Synthesis and Structural Characterization of Corrole and Sapphyrin Analogs of Imidazolium-Pyridine Cyclophanes”, Synlett 2005, (1) 99-102. http://dx.doi.org/10.1055/s-2004-836042 Al-Humydi, Abdulaziz; Garrison, Jered C.; Youngs, Wiley J.; Collins, Scott, “Propene Polymerization Using ansa-Metallocenium Ions: Excess Activator Effects on Polymerization Activity and Polymer Microstructure”, Organometallics 2005, 24(2), 93-196. http://dx.doi.org/10.1021/om0492092